Aging and Antiaging Strategies

Balistreri, Carmela Rita; Candore, Giuseppina; Scapagnini, Giovanni; Caruso, Calogero

doi:10.1007/978-3-662-47398-6_97

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…To date, nearly 2700 human mature miRNAs have been identified [ 63 ]; they are presumed to target over 60% of protein-coding genes in humans [ 24 ]. Additionally, miRNAs are thought to modulate the expression of approximately one-third of all human genetic codes [ 22 ].…”

Section: Biogenesis Of Micrornasmentioning

confidence: 99%

“…Additionally, it was shown that the binding of miRNA stimulates the initiation of mRNA decay factors and a subsequent potentiation of mRNA instability and degradation, resulting in a reduction in expression levels [ 25 ]. Furthermore, miRNAs were proven to participate in numerous pathobiological processes, such as cell proliferation, differentiation, apoptosis/necrosis, tissue degeneration, cancer, and age-related diseases [ 22 ].…”

Section: Biogenesis Of Micrornasmentioning

confidence: 99%

“…The data described here show that the expression of senescence-associated miRNAs affects the functioning of various genes in cutaneous cells and might promote or counteract cellular senescence. Moreover, many of these genes are expressed in other body tissues (e.g., p63 , SIRT1 ) and are directly linked to organismal aging [ 22 ].…”

Section: The Role Of Micrornas In the Dermal Agingmentioning

confidence: 99%

“…The potential role of miRNAs in aging biology is linked to the regulation of the expression of proteins maintaining the insulin-like growth factor (IGF)-1 and TOR signaling pathways [ 21 ]. Moreover, publications show that microRNAs play an essential role in regulating the balance between cellular proliferative capacity and replicative senescence [ 22 ]. The expression of various miRNAs was found to be directly associated with lifespan duration, ARDs, or their predisposition.…”

Section: Introductionmentioning

confidence: 99%

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The Role of microRNAs in Organismal and Skin Aging

Gerasymchuk

Cherkasova

Kovalchuk

et al. 2020

IJMS

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The aging process starts directly after birth and lasts for the entire lifespan; it manifests itself with a decline in an organism’s ability to adapt and is linked to the development of age-related diseases that eventually lead to premature death. This review aims to explore how microRNAs (miRNAs) are involved in skin functioning and aging. Recent evidence has suggested that miRNAs regulate all aspects of cutaneous biogenesis, functionality, and aging. It has been noted that some miRNAs were down-regulated in long-lived individuals, such as let-7, miR-17, and miR-34 (known as longevity-related miRNAs). They are conserved in humans and presumably promote lifespan prolongation; conversely, they are up-regulated in age-related diseases, like cancers. The analysis of the age-associated cutaneous miRNAs revealed the increased expression of miR-130, miR-138, and miR-181a/b in keratinocytes during replicative senescence. These miRNAs affected cell proliferation pathways via targeting the p63 and Sirtuin 1 mRNAs. Notably, miR-181a was also implicated in skin immunosenescence, represented by the Langerhans cells. Dermal fibroblasts also expressed increased the levels of the biomarkers of aging that affect telomere maintenance and all phases of the cellular life cycle, such as let-7, miR-23a-3p, 34a-5p, miR-125a, miR-181a-5p, and miR-221/222-3p. Among them, the miR-34 family, stimulated by ultraviolet B irradiation, deteriorates collagen in the extracellular matrix due to the activation of the matrix metalloproteinases and thereby potentiates wrinkle formation. In addition to the pro-aging effects of miRNAs, the plausible antiaging activity of miR-146a that antagonized the UVA-induced inhibition of proliferation and suppressed aging-related genes (e.g., p21WAF-1, p16, and p53) through targeting Smad4 has also been noticed. Nevertheless, the role of miRNAs in skin aging is still not fully elucidated and needs to be further discovered and explained.

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Section: Biogenesis Of Micrornasmentioning

confidence: 99%

Section: Biogenesis Of Micrornasmentioning

confidence: 99%

Section: The Role Of Micrornas In the Dermal Agingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Role of microRNAs in Organismal and Skin Aging

Gerasymchuk

Cherkasova

Kovalchuk

et al. 2020

IJMS

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“…Skin health is not only undermined by internal general aging processes, but also by environmental stressors, changing not only its appearance but also its physiological functions [ 36 ]. Among others, UVR exposure accelerates the rate of skin degeneration over skin regeneration.…”

Section: Discussionmentioning

confidence: 99%

Photoprotective and Antiaging Effects of a Standardized Red Orange (Citrus sinensis (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized, Double-Blind, Controlled Study

Nobile¹,

Burioli²,

Yu³

et al. 2022

Nutrients

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The increase in solar ultraviolet radiation (UVR) that reaches the Earth’s surface should make us reflect on the need to develop new approaches in protecting the skin from UVR exposure. The present study aims to evaluate the photoprotective and antiaging efficacy of a red orange extract (100 mg/day) in both Asian and Caucasian subjects. A randomized, double-blind, controlled study was carried out in 110 Asian and Caucasian subjects. Product efficacy was measured as follows: (1) the photoprotective effect was measured by the minimal erythema dose (MED) assessment; (2) the efficacy in decreasing the UVA+B-induced skin redness was measured by colorimetry; (3) the antioxidant efficacy was measured by the ferric-reducing antioxidant power (FRAP) and the malondialdehyde (MDA) assay; and (4) skin moisturization, skin elasticity, skin radiance, the intensity of melanin staining, transepidermal water loss (TEWL), and wrinkles were measured to assess the antiaging efficacy. The intake of the product for 56 days was effective in improving the skin reaction to UV exposure; in increasing the skin antioxidant capacity as well as in decreasing UVA-induced lipid peroxidation; in increasing the skin moisturization, skin elasticity, and skin radiance; and in decreasing TEWL, the intensity of melanin staining inside dark spots, and wrinkle depth. Our results suggest that the test product is effective in counteracting both the harmful effects of UVR exposure and aging signs.

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