Aging and DNA methylation

Jung, Myung-Hwan; Pfeifer, Gerd P.

doi:10.1186/s12915-015-0118-4

Cited by 432 publications

(305 citation statements)

References 94 publications

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“…This is in line with the report that only 5-10% of cancers are due to gene abnormalities inherited from parents and that about 90-95% of cases are attributed to epigenetic factors, 'wear and tear' of life in general [3]. DNA methylation is vital during development, and aberrant DNA methylation, both hypermethylation and demethylation, have been associated with aging, cancer and other diseases [19]. Therefore, methods to study DNA methylation are important tools in biological research.…”

Section: Discussionsupporting

confidence: 75%

Assessment of DNA methylation patterns in breast tumours and apparently healthy subjects in Anambra state, Nigeria

Ezeani¹,

Onyenekwe²,

Meludu³

et al. 2017

Integr Cancer Sci Therap.

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Section: Discussionsupporting

confidence: 75%

Assessment of DNA methylation patterns in breast tumours and apparently healthy subjects in Anambra state, Nigeria

Ezeani¹,

Onyenekwe²,

Meludu³

et al. 2017

Integr Cancer Sci Therap.

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“…Aberrant DNA methylation is common in cancer and aging (Sandoval & Esteller, 2012; Jung & Pfeifer, 2015). We examined global and site‐specific changes in DNA methylation in our lung cancer model.…”

Section: Resultsmentioning

confidence: 99%

Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene‐induced lung tumors in aged mice

et al. 2017

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SummaryAging is often accompanied by a dramatic increase in cancer susceptibility. To gain insights into how aging affects tumor susceptibility, we generated a conditional mouse model in which oncogenic Kras G12D was activated specifically in lungs of young (3–5 months) and old (19–24 months) mice. Activation of Kras G12D in old mice resulted in shorter survival and development of higher‐grade lung tumors. Six weeks after Kras G12D activation, old lung tissues contained higher numbers of adenomas than their young tissue counterparts. Lung tumors in old mice displayed higher proliferation rates, as well as attenuated DNA damage and p53 tumor suppressor responses. Gene expression comparison of lung tumors from young and old mice revealed upregulation of extracellular matrix‐related genes in young tumors, indicative of a robust cancer‐associated fibroblast response. In old tumors, numerous inflammation‐related genes such as Ccl7,IL‐1β, Cxcr6, and IL‐15ra were consistently upregulated. Increased numbers of immune cells were localized around the periphery of lung adenomas from old mice. Our experiments indicate that more aggressive lung tumor formation in older Kras G12D mice may be in part the result of subdued tumor suppressor and DNA damage responses, an enhanced inflammatory milieu, and a more accommodating tissue microenvironment.

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“…Presumably, this is the reason of an almost identical number of CGIs among these genomes. Previous studies Weidner et al 2014;Jung and Pfeifer 2015) have revealed that lifespan, body temperature, and body mass are related to CGIs. Thus, the records of body temperature, body mass, and lifespan retrieved from AnAge database (http:// genomics.senescence.info/species/) as well as the correlation between CGI density and these traits were calculated for even-toed ungulate genomes.…”

Section: Resultsmentioning

confidence: 99%

Genome-wide analysis of CpG islands in some livestock genomes and their relationship with genomic features

Barazandeh¹,

Mohammadabadi²,

Ghaderi–Zefrehei³

et al. 2016

Czech J. Anim. Sci.

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CpG islands (CGIs) are an important group of CpG dinucleotides in the guanine-and cytosinerich regions as they harbour functionally relevant epigenetic loci for whole genome studies. As a matter of fact, since there has not been a formal comparative analysis of CGIs in domestic even-toed ungulate genomes, this study was performed to serve this comparison. The Hidden Markov Model was used to detect CGIs in the genomes. The results indicated that the CGIs number and CGI densities had scant variations across genomes. The goat genome had the highest number of CGIs (99 070), whereas the alpaca genome had the highest CGI density (43.39 CGIs/Mb). Significant positive correlations were observed among CGI densities with chromosome pair number, observed CpG/expected CpG, recombination rate, and gene density. When the size of chromosomes increased, the CGI densities decreased and a trend of higher CGI densities in the telomeric regions was observed. Only 10.96% of CGIs were methylated underscoring this postulation that the majority of CGIs remains to be unmethylated. The highest amount of the methylated CGIs was observed in the introns, intergenic, and coding (CDS) regions and the lowest amount of the methylated CGIs was observed in the promoter regions, implying that the DNA methylation of CGIs may control gene expression at the genome level. Detected differences between even-toed ungulate and other vertebrate genomes showed that CGI densities varied greatly among the genomes. These findings would contribute to better understanding the even-toed ungulate (epi) genomes, the role of CGIs in epigenomic functions and molecular evolution.

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Aging and DNA methylation

Cited by 432 publications

References 94 publications

Assessment of DNA methylation patterns in breast tumours and apparently healthy subjects in Anambra state, Nigeria

Assessment of DNA methylation patterns in breast tumours and apparently healthy subjects in Anambra state, Nigeria

Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene‐induced lung tumors in aged mice

Genome-wide analysis of CpG islands in some livestock genomes and their relationship with genomic features

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