Comprehensive Physiology 2022
DOI: 10.1002/cphy.c210035
|View full text |Cite
|
Sign up to set email alerts
|

Aging and Heart Failure with Preserved Ejection Fraction

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
5
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(5 citation statements)
references
References 127 publications
0
5
0
Order By: Relevance
“…HFpEF, traditionally attributed to left ventricular diastolic dysfunction, has been reported as the induction of a systemic pro‐inflammatory state. 10 A chronic pro‐inflammatory state, contributing to interstitial fibrosis, endothelial dysfunction, cardiac myocyte stiffening, and LV remodeling, appears to be the predominant pathophysiological mechanism in HFpEF. 11 , 12 Indeed, it has been demonstrated that increased inflammatory markers are associated with the development of HFpEF in elderly patients.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…HFpEF, traditionally attributed to left ventricular diastolic dysfunction, has been reported as the induction of a systemic pro‐inflammatory state. 10 A chronic pro‐inflammatory state, contributing to interstitial fibrosis, endothelial dysfunction, cardiac myocyte stiffening, and LV remodeling, appears to be the predominant pathophysiological mechanism in HFpEF. 11 , 12 Indeed, it has been demonstrated that increased inflammatory markers are associated with the development of HFpEF in elderly patients.…”
Section: Discussionmentioning
confidence: 99%
“…HFpEF, traditionally attributed to left ventricular diastolic dysfunction, has been reported as the induction of a systemic proinflammatory state. 10 A chronic pro-inflammatory state, contributing…”
Section: Association Between Omentin-1 and Hfpef Diagnosismentioning
confidence: 99%
“…In particular, heart failure with preserved ejection fraction (HFpEF), which is characterized by diastolic dysfunction, altered ventricular relaxation and filling, increased stiffness, and concentric cardiac remodeling (fibrosis, inflammation, and hypertrophy), represents one of the most complex and prevalent cardiometabolic diseases in the aging population [135][136][137]. HFpEF leads to pressure, but not volume overload, and is present frequently with comorbidities, such as advanced age, obesity, diabetes, and hypertension [138]. Most currently available drugs for HF show little or no effect on mortality rates in patients with HFpEF, confirmed by numerous clinical trials.…”
Section: Heartmentioning
confidence: 99%
“…HFpEF is characterized by an increase in filling pressures caused by the complex interaction of multiple components, of which the concentric remodeling of the left ventricle (LV) is a relevant component [13]. It is well known that the increase in heart stiffness resulting from aging is an important cause of diastolic dysfunction; therefore, the general aging of the population concurs with a further increase in the prevalence of HFpEF in the coming decades [14]. Furthermore, the current lack of specific therapies for this condition will make HFpEF one of the most relevant issues to be addressed.…”
Section: Heart Failurementioning
confidence: 99%