Aging and left ventricular function in elderly healthy people

Lernfeit, Bodil; Wikstrand, John; Svanborg, Alvar; Landahl, Sten

doi:10.1016/0002-9149(91)90797-o

Cited by 33 publications

(9 citation statements)

References 12 publications

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“…A previous study of our population [1] between age 70 and 82 has shown an aging-related increase in SBP up to age 75, and a decline thereafter in both SBP and DBP. In a subgroup from the same population representing the healthiest individuals, the SBP increased up to age 85 years [23]. Some population studies have indicated that the SBP continues to increase throughout life [5,6].…”

Section: Discussionmentioning

confidence: 99%

Change in Blood Pressure in the Age Interval 70-90. Late Blood Pressure Peak Related to Longer Survival

Lernfelt

Svanborg

2002

Blood Pressure

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Section: Discussionmentioning

confidence: 99%

Change in Blood Pressure in the Age Interval 70-90. Late Blood Pressure Peak Related to Longer Survival

Lernfelt

Svanborg

2002

Blood Pressure

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“…Various studies have documented an increase in wall thickness with age in the presence of unchanged chamber volume. [1][2][3] In addition to the increased size of the myocytes, the aging heart is characterised by a high rate of degenerative age-associated findings such as lipid deposition, tubular dilatation and decreased mitochondrial oxidative phosphorylation. 3,4 Concomitantly, the amount of elastic tissue, collagen and fat increases.…”

Section: Left Ventricular Hypertrophymentioning

confidence: 99%

The heart in the hypertensive elderly

Grodzicki

Messerli

1998

J Hum Hypertens

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Left ventricular (LV) mass progressively increases throughout life, reaching its greatest magnitude in senescence. In the normotensive elderly, left ventricular hypertrophy (LVH) is mostly a consequence of a degenerative process in connective tissue. In hypertensive patients, LVH results from an increase in muscle mass and fibrotic tissue. LVH by echocardiographic criteria can be found in up to 50% of elderly patients with hypertension.Although associated with aging, LVH is associated with a higher rate of non-fatal and fatal cardiovascular events. Even in the absence of coronary stenosis, LVH is associated with reduced coronary reserve, increased number of arrhythmias and progressive deterioration in Keywords: essential hypertension; elderly; left ventricular hypertrophy; drug therapy Left ventricular hypertrophyUnlike other organs, the heart does not atrophy with age; in fact even in normotensive subjects left ventricular (LV) mass progressively increases throughout life. Various studies have documented an increase in wall thickness with age in the presence of unchanged chamber volume. [1][2][3] In addition to the increased size of the myocytes, the aging heart is characterised by a high rate of degenerative age-associated findings such as lipid deposition, tubular dilatation and decreased mitochondrial oxidative phosphorylation.3,4 Concomitantly, the amount of elastic tissue, collagen and fat increases. Therefore, even in normotensive subjects LV mass progressively increases throughout life, reaching its greatest magnitude in senescence. The prevalence of electrocardiographically diagnosed LV hypertrophy (ECG-LVH) in the population-based studies has been described as 4.2% to 16.9% according to the Minnesota criteria. 5 The Cardiovascular Health Study, 6 in which electrocardiograms of 5150 adults older than 65 years were analysed, showed that according to the Minnesota code, LVH was found in 4.1% of women and 4.3% of men. In the Framingham study the prevalence of ECG-LVH rose linearly with age. and/or density of vasoconstrive receptors (alpha) to vasorelaxing receptors (beta) lead to the decrease in compliance of large arteries and higher peripheral resistance.3 Other factors possibly contributing to increased BP in the elderly population are decreased oestrogen production in women, increased level of catecholamines, obesity, high prevalence of renal insufficiency and frequent consumption of nonsteroidal anti-inflammatory agents. The prevalence of hypertension in the elderly may reach 60% of the general population. 8 LVH and hypertensionLVH by echocardiographic criteria can be found in up to 50% of elderly patients with hypertension. 9The hypertrophic senescent heart in the morphometric study of Olivetti et al 10 was characterised by an increase in average myocyte cell volume per nucleus and an augmentation in the total number of myocyte nuclei in the ventricle myocardium. These processes were associated with 95% enlargement of the myocardial interstitium. In hypertensive patients irrespective of age, LVH is a...

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“…However, there are atypical symptoms, such as shortness of breath (dyspnoea), (left) arm pain on exertion and worsening heart failure, also referred to as "ischaemic or anginal equivalent" (9)(10)(11)(12). Silent (asymptomatic) ischaemia is, however, the most common manifestation of chronic IHD (13,14).…”

Section: Introductionmentioning

confidence: 99%