Aging and Parkinson's disease as functional models of temporal order perception

Silva, Carolina Feher da; Morgero, Kelly; Mota, Adolfo José da; Piemonte, Maria Elisa Pimentel; Baldo, Marcus Vinícius C.

doi:10.1016/j.neuropsychologia.2015.09.029

Cited by 5 publications

(2 citation statements)

References 66 publications

(81 reference statements)

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“…Altered integrations, in PD, have been variously reported between sensory input [including a study with distractor stimuli (89)], motor performance, and memory or other cognitive tasks [ (58,60,62,68,(90)(91)(92)(93)(94)(95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105), see (64,65,106) for reviews; Table 1 summarizes these particular studies]. In the spirit of context-dependent studies in explicit timing tasks (described above), PD may increase the perceived duration not of time, but of an action [( 45), but see (105) for a contrary view]; may 108) studied visual saccades initiated after variable foreperiods before movement in PD (both ON and OFF meds) and PARKIN-associated parkinsonism (the PARKIN gene, also known as PRKN, encodes an ubiquitin ligase; various mutations of the gene have been associated with an autosomal recessive parkinsonism, typically of juvenile onset).…”

Section: Implicit Timing: Processing Delay or Other Aberrancy In Proc...mentioning

confidence: 99%

Review: Subjective Time Perception, Dopamine Signaling, and Parkinsonian Slowness

Miyawaki

2022

Front. Neurol.

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The association between idiopathic Parkinson's disease, a paradigmatic dopamine-deficiency syndrome, and problems in the estimation of time has been studied experimentally for decades. I review that literature, which raises a question about whether and if dopamine deficiency relates not only to the motor slowness that is an objective and cardinal parkinsonian sign, but also to a compromised neural substrate for time perception. Why does a clinically (motorically) significant deficiency in dopamine play a role in the subjective perception of time's passage? After a discussion of a classical conception of basal ganglionic control of movement under the influence of dopamine, I describe recent work in healthy mice using optogenetics; the methodology visualizes dopaminergic neuronal firing in very short time intervals, then allows for correlation with motor behaviors in trained tasks. Moment-to-moment neuronal activity is both highly dynamic and variable, as assessed by photometry of genetically defined dopaminergic neurons. I use those animal data as context to review a large experimental experience in humans, spanning decades, that has examined subjective time perception mainly in Parkinson's disease, but also in other movement disorders. Although the human data are mixed in their findings, I argue that loss of dynamic variability in dopaminergic neuronal activity over very short intervals may be a fundamental sensory aspect in the pathophysiology of parkinsonism. An important implication is that therapeutic response in Parkinson's disease needs to be understood in terms of short-term alterations in dynamic neuronal firing, as has already been examined in novel ways—for example, in the study of real-time changes in neuronal network oscillations across very short time intervals. A finer analysis of a treatment's network effects might aid in any effort to augment clinical response to either medications or functional neurosurgical interventions in Parkinson's disease.

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Section: Implicit Timing: Processing Delay or Other Aberrancy In Proc...mentioning

confidence: 99%

Review: Subjective Time Perception, Dopamine Signaling, and Parkinsonian Slowness

Miyawaki

2022

Front. Neurol.

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“…time estimation, time reproduction, and time production) [ 15 – 17 ]. For example, Feher et al [ 18 ] observed timing tasks performance in young, healthy and elderly individuals with PD. The results showed that PD patients present greater inaccuracy in TP and decision-making.…”

Section: Introductionmentioning

confidence: 99%

Neurochemical changes in basal ganglia affect time perception in parkinsonians

et al. 2018

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BackgroundParkinson’s disease is described as resulting from dopaminergic cells progressive degeneration, specifically in the substantia nigra pars compacta that influence the voluntary movements control, decision making and time perception.AimThis review had a goal to update the relation between time perception and Parkinson’s Disease.MethodologyWe used the PRISMA methodology for this investigation built guided for subjects dopaminergic dysfunction in the time judgment, pharmacological models with levodopa and new studies on the time perception in Parkinson’s Disease. We researched on databases Scielo, Pubmed / Medline and ISI Web of Knowledge on August 2017 and repeated in September 2017 and February 2018 using terms and associations relevant for obtaining articles in English about the aspects neurobiology incorporated in time perception. No publication status or restriction of publication date was imposed, but we used as exclusion criteria: dissertations, book reviews, conferences or editorial work.Results/DiscussionWe have demonstrated that the time cognitive processes are underlying to performance in cognitive tasks and that many are the brain areas and functions involved and the modulators in the time perception performance.ConclusionsThe influence of dopaminergic on Parkinson’s Disease is an important research tool in Neuroscience while allowing for the search for clarifications regarding behavioral phenotypes of Parkinson’s disease patients and to study the areas of the brain that are involved in the dopaminergic circuit and their integration with the time perception mechanisms.

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