Aging and Senescence of Dental Pulp and Hard Tissues of the Tooth

Maeda, Hidefumi

doi:10.3389/fcell.2020.605996

Cited by 48 publications

(49 citation statements)

References 93 publications

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“…Dental tissue-derived cells Long-term stress on teeth may induce the human dental pulp cells senescence and up-regulation of SASP factors in human dental pulp cells ( 32 ). In aging patients, dental pulp stem cells exhibit elevated expression of SASP factors ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Senescence-associated secretory phenotype and its impact on oral immune homeostasis

et al. 2022

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The senescence-associated secretory phenotype (SASP), which accumulates over the course of normal aging and in age-related diseases, is a crucial driver of chronic inflammation and aging phenotypes. It is also responsible for the pathogenesis of multiple oral diseases. However, the pathogenic mechanism underlying SASP has not yet been fully elucidated. Here, relevant articles on SASP published over the last five years (2017–2022) were retrieved and used for bibliometric analysis, for the first time, to examine SASP composition. More than half of the relevant articles focus on various cytokines (27.5%), growth factors (20.9%), and proteases (20.9%). In addition, lipid metabolites (13.1%) and extracellular vesicles (6.5%) have received increasing attention over the past five years, and have been recognized as novel SASP categories. Based on this, we summarize the evidences demonstrating that SASP plays a pleiotropic role in oral immunity and propose a four-step hypothetical framework for the progression of SASP-related oral pathology—1) oral SASP development, 2) SASP-related oral pathological alterations, 3) pathological changes leading to oral immune homeostasis disruption, and 4) SASP-mediated immune dysregulation escalating oral disease. By targeting specific SASP factors, potential therapies can be developed to treat oral and age-related diseases.

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Section: Discussionmentioning

confidence: 99%

Senescence-associated secretory phenotype and its impact on oral immune homeostasis

et al. 2022

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“…Detailed knowledge of the spatial dimensions and architecture of the pulp compartments is of central importance for modern endodontic treatment approaches in human dental medicine. Therefore, it has been recommended to display the three-dimensional anatomy of the pulp systemthrough the use of cone-beam computed tomography prior to endodontic treatment [34,36,37].…”

Section: Morphology: Age-related Changes In the Equine Dental Pulpmentioning

confidence: 99%

The Equine Dental Pulp: Histomorphometric Analysis of the Equine Dental Pulp in Incisors and Cheek Teeth

Roßgardt

Heilen

Büttner

et al. 2022

Veterinary Sciences

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To maintain a healthy and functional status, equine hypsodont teeth have to produce lifelong large amounts of subocclusal dentin to prevent occlusal pulp exposure, which is caused by occlusal wear. To examine the cyto- and histological components that guarantee the lifelong high productivity of equine pulp, a limited number of ten incisors and ten cheek teeth from seven adult horses (aged 5 to 24 years) and five foals were sampled for preliminary histomorphometric and histomorphological evaluations. Independently of age, the equine dental pulp featured constant layers of predentin and odontoblastic cells, as well as soft connective tissue, composed of a cellular fibrous matrix, in which blood vessels and nerve fibers were embedded. As a result of the progressive deposition of newly formed dentin, the layer of dentin became thicker with age, and the size of the pulp chamber decreased. In contrast to the brachydont teeth, the morphological characteristics of the odontoblastic layer and the width of the predentin layer did not change with age. Therefore, it is assumed that the equine pulp tissue retained their juvenile status, which explains its unchanged ability to produce high amounts of subocclusal dentin. These preliminary, but clinically significant, findings are worthy of further investigation in order to identify strategies for equine-specific endodontic therapies.

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“…The results on the proteome of the dental pulp refer to adolescents and young adults, the typical age at which wisdom teeth are removed for dental reasons. Like other organs, the dental pulp is also subject to an aging process [42]. It is entirely possible that proteome analyses of teeth extracted from older patients have a different protein composition pattern than those from younger individuals.…”

Section: Limitations Of Studymentioning

confidence: 99%

Complementing the pulp proteome via sampling with a picosecond infrared laser (PIRL)

et al. 2021

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Objectives The aim of this investigation was the detailed analysis of the human pulp proteome using the new picosecond infrared laser (PIRL)-based sampling technique, which is based on a completely different mechanism compared to mechanical sampling. Proteome analysis of healthy pulp can provide data to define changes in the proteome associated with dental disease. Material and methods Immediately after extraction of the entire, undamaged tooth, 15 wisdom teeth were deep frozen in liquid nitrogen and preserved at −80°C. Teeth were crushed, and the excised frozen pulps were conditioned for further analysis. The pulps were sampled using PIRL, and the aspirates digested with trypsin and analyzed with mass spectrometry. Pulp proteins were categorized according to their gene ontology terminus. Proteins identified exclusively in this study were searched in the Human Protein Atlas (HPA) for gaining information about the main known localization and function. Results A total of 1348 proteins were identified in this study. The comparison with prior studies showed a match of 72%. Twenty-eight percent of the proteins were identified exclusively in this study. Considering HPA, almost half of these proteins were assigned to tissues that could be pulp specific. Conclusion PIRL is releasing proteins from the dental pulp which are not dissolved by conventional sampling techniques. Clinical Relevance The presented data extend current knowledge on dental pulp proteomics in healthy teeth and can serve as a reference for studies on pulp proteomics in dental disease.

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Aging and Senescence of Dental Pulp and Hard Tissues of the Tooth

Cited by 48 publications

References 93 publications

Senescence-associated secretory phenotype and its impact on oral immune homeostasis

Senescence-associated secretory phenotype and its impact on oral immune homeostasis

The Equine Dental Pulp: Histomorphometric Analysis of the Equine Dental Pulp in Incisors and Cheek Teeth

Complementing the pulp proteome via sampling with a picosecond infrared laser (PIRL)

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