Aging and the intestine

Drozdowski, Laurie

doi:10.3748/wjg.v12.i47.7578

Cited by 109 publications

(79 citation statements)

References 90 publications

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“…These data are consistent with a similar study performed on rats (Smits and Lefebvre, 1996), but differ from a model of premature aging, the klotho mouse, where reduced fecal output was linked to a decrease in food intake (Asuzu et al, 2011). Increases in the rate of nutrient absorption with age could also contribute to our observations, although this seems unlikely based on earlier studies, which suggest that the rate of absorption of nutrients from the small intestine is reduced with increasing age (Drozdowski and Thomson, 2006;Thomson, 2009). …”

Section: Effects Of Age On Fecal Output and The Properties Of Fecal Psupporting

confidence: 92%

Impaired colonic motility and reduction in tachykinin signalling in the aged mouse

Patel

Fidalgo

et al. 2014

Experimental Gerontology

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Section: Effects Of Age On Fecal Output and The Properties Of Fecal Psupporting

confidence: 92%

Impaired colonic motility and reduction in tachykinin signalling in the aged mouse

Patel

Fidalgo

et al. 2014

Experimental Gerontology

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“…Advanced age is known to affect intestinal function, including enterocyte structure and nutrient absorption (Drozdowski and Thomson, 2006). Yet little is known about age-related differences in intestinal xenobiotic metabolism enzymes.…”

Section: Discussionmentioning

confidence: 99%

Microsomal Quercetin Glucuronidation in Rat Small Intestine Depends on Age and Segment

Bolling

Court²,

Blumberg³

et al. 2011

Drug Metab Dispos

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ABSTRACT:UDP-glucuronosyltransferase (UGT) activity toward the flavonoid quercetin and UGT protein were characterized in three equidistant small intestine (SI) segments from 4-, 12-, 18-, and 28-month-old male Fischer 344 rats (n ‫؍‬ 8/age) using villin to control for enterocyte content. SI microsomal intrinsic clearance of quercetin was increased 3-to 9-fold from 4 months in the proximal and distal SI at 12 and 18 months. Likewise, at 30 M quercetin, SI microsomal glucuronidation activity was increased with age: 4.8-and 3.9-fold greater at 18 months than at 4 months. Quercetin UGT regioselectivity was not changed by age. The distal SI preferentially catalyzed glucuronidation at the 7-position, whereas the proximal SI produced the greatest proportion of 4-and 3-conjugates. Enterocyte UGT content in different SI segments was not consistently changed with age. In the proximal SI, UGT1A increased 64 and 150% at 12 and 18 months and UGT1A1, UGT1A7, and UGT1A8 were also increased at 12 and 18 months. However, age-related changes in expression were inconsistent in the medial and distal segments. Microsomal rates of quercetin glucuronidation and UGT expression were positively correlated with UGT1A1 content for all pooled samples (r ‫؍‬ 0.467) and at each age (r ‫؍‬ 0.538-0.598). UGT1A7 was positively correlated with total, 7-O-and 3-O-quercetin glucuronidation at 18 months. Thus, age-related differences in UGT quercetin glucuronidation depend on intestinal segment, are more pronounced in the proximal and distal segments and may be partially related to UGT1A1 and UGT1A7 content.

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“…We conducted this study to identify effective methods of increasing lutein concentrations in the elderly. Digestion and absorption of carotenoids are considered to be influenced by aging with impairments of gastrointestinal transit, lipase and bile salt secretion (36). Since our subjects were not elderly, further studies are needed to clarify effects on the absorption of lutein in the elderly population.…”

Section: Discussionmentioning

confidence: 99%

Effects of Mayonnaise on Postprandial Serum Lutein/Zeaxanthin and β-Carotene Concentrations in Humans

Takeda

Masuda

Usuda

et al. 2009

J Nutr Sci Vitaminol

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Summary To clarify the effects of different physical forms of oil on postprandial serum lutein/zeaxanthin and ␤ -carotene concentrations, we performed a vegetable meal loading test. Eighteen healthy subjects participated in the test, which consisted of broccoli as a control (CON) meal, broccoli with oil (OIL), and broccoli with mayonnaise (MS), consumed in random order. After collection of fasting blood samples, subjects consumed one of the three test meals. Fasting and postprandial changes in serum carotenoids were assessed 2, 4, and 6 h after ingestion of each test meal. Serum lutein/zeaxanthin and ␤ -carotene concentrations were measured. Although no significant change was noted after the CON meal, the serum lutein/zeaxanthin concentration was higher at 4 h after consumption of the OIL meal, and at 2, 4 and 6 h after consumption of the MS meal, as compared with the fasting state. Serum ␤ -carotene concentrations did not change after ingestion of either the CON or the OIL meal but were elevated 2, 4, and 6 h after MS ingestion as compared with the fasting state. The incremental areas under the curves (IAUCs) of serum lutein/zeaxanthin and ␤ -carotene concentrations were higher after the MS meal than after the CON meal. IAUCs after the OIL meal exhibited no statistically significant differences from the CON and MS meals. We suggest that mayonnaise contributes to increase serum lutein/zeaxanthin and ␤ -carotene concentrations when consumed with vegetables rich in these carotenoids.

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Aging and the intestine

Cited by 109 publications

References 90 publications

Impaired colonic motility and reduction in tachykinin signalling in the aged mouse

Impaired colonic motility and reduction in tachykinin signalling in the aged mouse

Microsomal Quercetin Glucuronidation in Rat Small Intestine Depends on Age and Segment

Effects of Mayonnaise on Postprandial Serum Lutein/Zeaxanthin and β-Carotene Concentrations in Humans

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