Aging changes in the kidneys of two poeciliid fishes, the guppy Poecilia reticulatus and the Amazon molly P. formosa

Woodhead, Avril D.; Pond, Virginia; Dailey, K.

doi:10.1016/0531-5565(83)90033-5

Cited by 22 publications

(5 citation statements)

References 11 publications

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“…Various degenerative lesions were observed in liver, kidney, heart, and gonads, suggesting that death was caused by systemic failure. Similar aging‐related lesions were described in other fish species, for example, tubule dilation in the kidney in poeciliid fish (Woodhead et al. , 1983) and liver apoptosis in medaka (Ding et al.…”

Section: Discussionsupporting

confidence: 68%

Mapping of quantitative trait loci controlling lifespan in the short‐lived fish Nothobranchius furzeri– a new vertebrate model for age research

et al. 2012

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The African annual fish Nothobranchius furzeri emerged as a new model for age research over recent years. Nothobranchius furzeri show an exceptionally short lifespan, age-dependent cognitive/behavioral decline, expression of age-related biomarkers, and susceptibility to lifespan manipulation. In addition, laboratory strains differ largely in lifespan. Here, we set out to study the genetics of lifespan determination. We crossed a short- to a long-lived strain, recorded lifespan, and established polymorphic markers. On the basis of genotypes of 411 marker loci in 404 F2 progeny, we built a genetic map comprising 355 markers at an average spacing of 5.5 cM, 22 linkage groups (LGs) and 1965 cM. By combining marker data with lifespan values, we identified one genome-wide highly significant quantitative trait locus (QTL) on LG 9 (P < 0.01), which explained 11.3% of the F2 lifespan variance, and three suggestive QTLs on LG 11, 14, and 17. We characterized the highly significant QTL by synteny analysis, because a genome sequence of N. furzeri was not available. We located the syntenic region on medaka chromosome 5, identified candidate genes, and performed fine mapping, resulting in a c. 40% reduction of the initial 95% confidence interval. We show both that lifespan determination in N. furzeri is polygenic, and that candidate gene detection is easily feasible by cross-species analysis. Our work provides first results on the way to identify loci controlling lifespan in N. furzeri and illustrates the potential of this vertebrate species as a genetic model for age research.

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Section: Discussionsupporting

confidence: 68%

Mapping of quantitative trait loci controlling lifespan in the short‐lived fish Nothobranchius furzeri– a new vertebrate model for age research

et al. 2012

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“…The cardiac lesions included hypertrophy of the cardiomyocytes (Di Cicco et al, ), another typical aspect of vertebrate ageing (Woodhead, ; Dai et al, ). Kidney lesions were similar to age‐dependent lesions described previously in P. reticulata (Woodhead, Pond & Dailey, ). Clearly, N. furzeri suffer from a rapid and concerted ageing process that affects several organs and is similar to that of other vertebrates, including humans.…”

Section: The Ageing Phenotypementioning

confidence: 99%

From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology

2015

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African annual fishes from the genus Nothobranchius are small teleosts that inhabit temporary water bodies subject to annual desiccation due to the alternation of the monsoon seasons. Given their unique biology, these fish have emerged as a model taxon in several biological disciplines. Their increasing popularity stems from the extremely short lifespan that is the result of their specific life-history adaptations and is retained under laboratory conditions. Nothobranchius furzeri, the most popular laboratory species, is the vertebrate species with the shortest lifespan recorded in captivity. In the laboratory, adults of different Nothobranchius species and populations live between 3 and 18 months and, notably, there is a negative correlation between the captive lifespan of a species and the aridity of their habitat. Their short lifespan is coupled to rapid age-dependent functional decline and expression of cellular and molecular changes comparable to those observed in other vertebrates, including humans. The recent development of transgenesis in this species makes it possible to insert specific constructs into their genome, and the establishment of transgenic lines is facilitated by their very rapid generation time, which can be as short as 1 month. This makes Nothobranchius species particularly suited for investigating biological and molecular aspects of ageing and ageing-associated dysfunctions. At the same time, they also represent a unique model taxon to investigate the evolution of life-history adaptations and their genetic architecture. We review their natural history, including phylogenetic relationships, distribution in relation to habitat conditions and natural selection for differential longevity, population structure and demography, and life cycle with emphasis on diapause that may occur at three stages during embryonic development. We further critically evaluate their use as a laboratory model for understanding the evolution of a rapid ageing rate and its consequences for other life-history traits, for cellular, molecular and integrative traits associated with the ageing process, high incidence of neoplasias, their utility for genome-wide gene-expression studies, and as a model for quantitative genetics. We summarize recent achievements in fostering Nothobranchius species as a widely applicable model system, including an annotated transcriptome, successful transgenesis, and existence of viable inbred lines. We compare the conditions they experience in the wild and in captivity and suggest that they are an ideal taxon to investigate natural genetic variation in a laboratory setting. We conclude that Nothobranchius species -and N. furzeri in particular -could become a unique model taxon that bridges interests in ecological and biomedical research. We hope that a conceptual and methodological integration of these two branches of biology will provide important new insights.

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“…The development of new model organisms is vital to compensate for the limitations of previous model systems. In the past, several fish species have been adopted as potential ageing model organisms, including medaka ( Ding et al, 2010 ; Egami and Eto, 1973 ; Gopalakrishnan et al, 2013 ), guppies ( Reznick et al, 2006 ; Woodhead and Pond, 1984 ; Woodhead et al, 1983 ) and both American as well as African killifish ( Liu and Walford, 1966 ; Markofsky and Milstoc, 1979a , b ). As highlighted in this article, the turquoise killifish has emerged as a promising new model organism for vertebrate ageing because it uniquely combines a short lifespan and life cycle with vertebrate-specific features that are missing from the currently used non-vertebrate model organisms.…”

Section: Looking Forward: Potential Applications and Limitations Of Kmentioning

confidence: 99%

The short-lived African turquoise killifish: an emerging experimental model for ageing

Kim

Nam

Valenzano

2016

Disease Models &Amp; Mechanisms

113

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Human ageing is a fundamental biological process that leads to functional decay, increased risk for various diseases and, ultimately, death. Some of the basic biological mechanisms underlying human ageing are shared with other organisms; thus, animal models have been invaluable in providing key mechanistic and molecular insights into the common bases of biological ageing. In this Review, we briefly summarise the major applications of the most commonly used model organisms adopted in ageing research and highlight their relevance in understanding human ageing. We compare the strengths and limitations of different model organisms and discuss in detail an emerging ageing model, the short-lived African turquoise killifish. We review the recent progress made in using the turquoise killifish to study the biology of ageing and discuss potential future applications of this promising animal model.

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Aging changes in the kidneys of two poeciliid fishes, the guppy Poecilia reticulatus and the Amazon molly P. formosa

Cited by 22 publications

References 11 publications

Mapping of quantitative trait loci controlling lifespan in the short‐lived fish Nothobranchius furzeri– a new vertebrate model for age research

Mapping of quantitative trait loci controlling lifespan in the short‐lived fish Nothobranchius furzeri– a new vertebrate model for age research

From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology

The short-lived African turquoise killifish: an emerging experimental model for ageing

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