Aging Clocks, Entropy, and the Challenge of Age Reversal

Tarkhov, Andrei E.; Denisov, Kirill A.; Fedichev, Peter O.

doi:10.59368/agingbio.20240031

AgingBio 2024

DOI: 10.59368/agingbio.20240031

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Aging Clocks, Entropy, and the Challenge of Age Reversal

Andrei E. Tarkhov,

Kirill A. Denisov,

Peter O. Fedichev

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2024

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Cited by 1 publication

References 70 publications

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LinAge2: Providing actionable insights and benchmarking with epigenetic clocks

Fong,

Denisov,

Kennedy

et al. 2024

Preprint

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Biological aging is marked by a decline in resilience at the cellular and systemic levels, driving an exponential increase in mortality risk. Here, we evaluate several clinical and epigenetic clocks for their ability to predict mortality, demonstrating that clocks trained on survival and functional aging outperform those trained on chronological age. We present an enhanced clinical clock that predicts mortality more accurately and provides actionable insights for guiding personalized interventions. These findings highlight the potential of mortality-predicting clocks to inform clinical decision-making and promote strategies for healthy longevity.

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LinAge2: Providing actionable insights and benchmarking with epigenetic clocks

Fong,

Denisov,

Kennedy

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Aging Clocks, Entropy, and the Challenge of Age Reversal

Cited by 1 publication

References 70 publications

LinAge2: Providing actionable insights and benchmarking with epigenetic clocks

LinAge2: Providing actionable insights and benchmarking with epigenetic clocks

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