Aging effects on memory encoding in the frontal lobes.

Stebbins, Glenn T.; Carrillo, Marı́a C.; Dorfman, Jennifer; Dirksen, Courtney; Desmond, John E.; Turner, David A.; Bennett, David A.; Wilson, Robert S.; Glover, Gary H.; Gabrieli, John D. E.

doi:10.1037/0882-7974.17.1.44

Cited by 189 publications

(136 citation statements)

References 66 publications

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“…In a functional MRI study (fMRI), Stebbins et al (2002) found less activation in left prefrontal cortex in older adults relative to younger adults while they carried out a single-word semantic judgment task. Using magnetoencephalography (MEG), Kemmotsu et al (2012) compared young to middle-aged adults (mean age of 50 years-old) during single-word semantic judgment task, and reported that middle-aged adults recruited the inferior prefrontal region to a lesser extent than young adults.…”

Section: Discussionmentioning

confidence: 99%

Neural changes associated with semantic processing in healthy aging despite intact behavioral performance

et al. 2015

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Semantic memory recruits an extensive neural network including the left inferior prefrontal cortex (IPC) and the left temporoparietal region, which are involved in semantic control processes, as well as the anterior temporal lobe region (ATL) which is considered to be involved in processing semantic information at a central level. However, little is known about the underlying neuronal integrity of the semantic network in normal aging. Young and older healthy adults carried out a semantic judgment task while their cortical activity was recorded using magnetoencephalography (MEG). Despite equivalent behavioral performance, young adults activated the left IPC to a greater extent than older adults, while the latter group recruited the temporoparietal region bilaterally and the left ATL to a greater extent than younger adults. Results indicate that significant neuronal changes occur in normal aging, mainly in regions underlying semantic control processes, despite an apparent stability in performance at the behavioral level.

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Section: Discussionmentioning

confidence: 99%

Neural changes associated with semantic processing in healthy aging despite intact behavioral performance

et al. 2015

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“…Cabeza et al, 2000;Logan et al, 2002;Morcom et al, 2003) and visuospatial (Grady et al, 1995(Grady et al, , 1998Kelley et al, 1998) information. In elders, reduction of left PFC activation has been linked to reduced performance (Stebbins et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Age-Related Functional Changes of Prefrontal Cortex in Long-Term Memory: A Repetitive Transcranial Magnetic Stimulation Study

Rossi¹,

Miniussi²,

Pasqualetti³

et al. 2004

J. Neurosci.

167

134

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Neuroimaging findings suggest that the lateralization of prefrontal cortex activation associated with episodic memory performance is reduced by aging. It is still a matter of debate whether this loss of asymmetry during encoding and retrieval reflects compensatory mechanisms or de-differentiation processes. We addressed this issue by the transient interference produced by repetitive transcranial magnetic stimulation (rTMS), which directly assesses causal relationships between performance and stimulated regions. We compared the effects of rTMS (a rapid-rate train occurring simultaneously to the presentation of memoranda) applied to the left or right dorsolateral prefrontal cortex (DLPFC) on visuospatial recognition memory in 66 healthy subjects divided in two classes of age (Ͻ45 and Ͼ50 years).In young subjects, rTMS of the right DLPFC interfered with retrieval more than left DLPFC stimulation. The asymmetry of the effect progressively vanished with aging, as indicated by bilateral interference effects on recognition performance. Conversely, the predominance of left DLPFC effect during encoding was not abolished in elders, thus probing its causal role for encoding along the life span. Findings confirm that the neural correlates of retrieval modify along aging, suggesting that the bilateral engagement of the DLPFC has a compensatory role on the elders' episodic memory performance.

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“…Simulating cognitive aging in younger adults by means of experimental manipulations (e.g., division of attention) has been a successful approach in behavioral studies (Ma¨ntyla¨and Ba¨ckman, 1992;Castel and Craik, 2003). The pharmacological approach proposed here would extend this research strategy to the neural level, and provide more mechanistic evidence pertaining to the role of DA neurotransmission in the age-differential patterns of brain activation often observed in functionalimaging studies (Rypma and D'Esposito, 2000;Rypma et al, 2001;Grady et al, 1995;Stebbins et al, 2002;Cabeza, 2002;Cabeza et al, 2002).…”

Section: Pharmacological Intervention Comt Genotype and Brain Activmentioning

confidence: 99%

“…By collecting PET-based DA data and functional-imaging data during task performance on the same individuals, several intriguing issues in the cognitive neuroscience of aging could be addressed. For example, in activation studies, an under-recruitment of task-relevant frontal regions has been associated with age-related deficits in tasks assessing working memory (Rypma and D'Esposito, 2000;Rypma et al, 2001) and episodic memory (Grady et al, 1995;Stebbins et al, 2002). In this context, it is of interest to note that several studies on DA and cognitive aging have used cognitively demanding tasks (e.g., executive tasks, episodic memory tasks) that have been shown to activate prefrontal regions in functional imaging studies (see Cabeza and Nyberg, 2000, for review).…”

Section: Da Imaging and Brain Activationmentioning

confidence: 99%

The correlative triad among aging, dopamine, and cognition: Current status and future prospects

Bäckman

Nyberg

Lindenberger

et al. 2006

Neuroscience & Biobehavioral Reviews

705

563

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The brain neuronal systems defined by the neurotransmitter dopamine (DA) have since long a recognized role in the regulation of motor functions. More recently, converging evidence from patient studies, animal research, pharmacological intervention, and molecular genetics indicates that DA is critically implicated also in higher-order cognitive functioning. Many cognitive functions and multiple markers of striatal and extrastriatal DA systems decline across adulthood and aging. Research examining the correlative triad among adult age, DA, and cognition has found strong support for the view that age-related DA losses are associated with age-related cognitive deficits. Future research strategies for examining the DA-cognitive aging link include assessing (a) the generality/specificity of the effects; (b) the relationship between neuromodulation and functional brain activation; and (c) the release of DA during actual task performance. r

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Aging effects on memory encoding in the frontal lobes.

Cited by 189 publications

References 66 publications

Neural changes associated with semantic processing in healthy aging despite intact behavioral performance

Neural changes associated with semantic processing in healthy aging despite intact behavioral performance

Age-Related Functional Changes of Prefrontal Cortex in Long-Term Memory: A Repetitive Transcranial Magnetic Stimulation Study

The correlative triad among aging, dopamine, and cognition: Current status and future prospects

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