Aging Immune System and Its Correlation With Liability to Severe Lung Complications

Li, Yongtao; Wang, Chengfei; Peng, Meilian

doi:10.3389/fpubh.2021.735151

Cited by 20 publications

(14 citation statements)

References 70 publications

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“…times higher number of COVID-19 patients [19]. The correlation between aging and declined innate immunity generally explained the more susceptibility of older persons to infection [20]. Biswas et al (2020) found that male patients with COVID-19 were associated with a significantly increased risk of death by 1.86 times compared to female patients, but we did not study the association between age and gender with the severity of the disease [21].…”

Section: Spearman Correlation Testmentioning

confidence: 89%

Higher Inflammatory Markers are correlated with Worse Cognitive Function in Coronavirus Disease-2019 Patients

Fitri

Darman

Ritarwan

2022

Open Access Maced J Med Sci

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AIM: This study aimed to determine the correlation between inflammation with cognitive function in COVID-19 patients. METHODS: We recruited COVID-19 patients using consecutive sampling methods in Adam Malik General Hospital Medan, Indonesia. The neutrophil-to-lymphocyte ratio (NLR,) C-reactive protein (CRP), D-dimer, and ferritin serum levels were measured as inflammatory markers . Cognitive function was assessed in several cognitive domains using Forward Digit Span for attention, Bacward Digit Span for working memory, and Trail Making Test parts A and B for executive function. The correlation between inflammatory markers and cognitive function was analyzed using Spearman correlation test. RESULTS: This study involved 40 COVID-19 patients consisting of 13 (32.5%) males and 27 (67.5%) females; the median age of the patients was 39.5 (19–65) years. We found that higher D-dimer and ferritin levels were significantly correlated with worse BDS scores (r = −0.369 p = 0.019 and r = −0.408 p = 0.009, respectively) and higher ferritin level was also correlated with worse FDS score (r = −0.365 p = 0.020 and). Higher D-dimer and ferritin levels were also significantly correlated with a longer time of completion of TMT-B (r = 0.363 p = 0.022 and r = 0.433 p = 0.005) and higher ferritin level was also correlated with a longer time of completion of TMT-A (r = 0.438 P=0.005). There were no significant correlations between NLR and CRP levels with cognitive function. CONCLUSION: Higher inflammatory markers are correlated with worse attention, working memory, and executive function in COVID-19 patients.

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Section: Spearman Correlation Testmentioning

confidence: 89%

Higher Inflammatory Markers are correlated with Worse Cognitive Function in Coronavirus Disease-2019 Patients

Fitri

Darman

Ritarwan

2022

Open Access Maced J Med Sci

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“…In addition, we found that both recipient and donor age negatively affected B-cell reconstitution. This may indicate that thymic function and bone marrow activity deteriorate with aging, which impairs the production of naïve and mature B cells [34][35][36][37]. However, further studies are needed to elucidate the mechanisms of delayed B-cell immune reconstitution associated with aging.…”

Section: Discussionmentioning

confidence: 99%

The dynamics of B‐cell reconstitution post allogeneic hematopoietic stem cell transplantation: A real‐world study

Zhou,

Zhan,

Huang

et al. 2024

J Intern Med

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BackgroundThe immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is crucial for preventing infections and relapse and enhancing graft‐versus‐tumor effects. B cells play an important role in humoral immunity and immune regulation, but their reconstitution after allo‐HSCT has not been well studied.MethodsIn this study, we analyzed the dynamics of B cells in 252 patients who underwent allo‐HSCT for 2 years and assessed the impact of factors on B‐cell reconstitution and their correlations with survival outcomes, as well as the development stages of B cells in the bone marrow and the subsets in the peripheral blood.ResultsWe found that the B‐cell reconstitution in the bone marrow was consistent with the peripheral blood (p = 0.232). B‐cell reconstitution was delayed by the male gender, age >50, older donor age, the occurrence of chronic and acute graft‐versus‐host disease, and the infections of fungi and cytomegalovirus. The survival analysis revealed that patients with lower B cells had higher risks of death and relapse. More importantly, we used propensity score matching to obtain the conclusion that post‐1‐year B‐cell reconstitution is better in females. Meanwhile, using mediation analysis, we proposed the age‐B cells‐survival axis and found that B‐cell reconstitution at month 12 posttransplant mediated the effect of age on patient survival (p = 0.013). We also found that younger patients showed more immature B cells in the bone marrow after transplantation (p = 0.037).ConclusionOur findings provide valuable insights for optimizing the management of B‐cell reconstitution and improving the efficacy and safety of allo‐HSCT.

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“…Pneumonia, an inflammatory lung infection, poses substantial risks for the elderly [ 54 , 55 , 56 ]. Aging weakens the immune system, making older adults more susceptible to severe pneumonia, often resulting in hospitalization and, in severe cases, mortality [ 57 , 58 ]. According to the Centers for Disease Control and Prevention (CDC), about 150,000 adults aged 65+ years are annually hospitalized due to pneumonia in the USA [ 59 ].…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

Pulmonary Diseases in Older Patients: Understanding and Addressing the Challenges

Joshi

2024

Geriatrics

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As the global population ages, pulmonary diseases among older people have emerged as a significant and growing public health concern. The increasing incidence of these conditions has led to higher rates of morbidity and mortality among older adults. This perspective study offers a thorough overview of the prevalent pulmonary diseases affecting the elderly demographic. It delves into the challenges encountered during the diagnosis and management of these conditions in older individuals, considering factors such as comorbidities, functional limitations, and medication complexities. Furthermore, innovative strategies and personalized interventions such as precision medicine, advanced therapies, telemedicine solutions, and patient-centered support systems aimed at enhancing the care provided to older individuals grappling with pulmonary disorders are thoroughly explored. By addressing the unique needs and complexities of this vulnerable population, healthcare systems can strive towards improving outcomes and enhancing the quality of life for elderly individuals affected by pulmonary diseases.

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Aging Immune System and Its Correlation With Liability to Severe Lung Complications

Cited by 20 publications

References 70 publications

Higher Inflammatory Markers are correlated with Worse Cognitive Function in Coronavirus Disease-2019 Patients

Higher Inflammatory Markers are correlated with Worse Cognitive Function in Coronavirus Disease-2019 Patients

The dynamics of B‐cell reconstitution post allogeneic hematopoietic stem cell transplantation: A real‐world study

Pulmonary Diseases in Older Patients: Understanding and Addressing the Challenges

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