Aging in skin of color

Venkatesh, Samantha; Maymone, Mayra B.C.; Vashi, Neelam A.

doi:10.1016/j.clindermatol.2019.04.010

Cited by 50 publications

(50 citation statements)

References 29 publications

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“…More broadly, our observations are consistent with the higher rate of wrinkling in Europeans, probably reflecting the greater sensitivity to ultraviolet damage of more lightly pigmented skin. 6,41 In addition, although other studies have strongly associated SLC45A2 with pigmentation and melanoma, 61,62 to our knowledge this is the first time that variants in this gene region are associated with mole count, a well-established risk factor for melanoma. 63,64 In conclusion, the effect of variants at SLC45A2, IRF4 and MC1R on skin ageing is detectable in young adults of mixed Native American, European and African ancestry, who have not yet developed the classic deep-wrinkling phenotype associated with long-term skin photodamage.…”

Section: Discussionmentioning

confidence: 88%

A genome‐wide association study identifies novel gene associations with facial skin wrinkling and mole count in Latin Americans

et al. 2021

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Background Genome-wide association studies (GWASs) have identified genes influencing skin ageing and mole count in Europeans, but little is known about the relevance of these (or other genes) in non-Europeans. Objectives To conduct a GWAS for facial skin ageing and mole count in adults < 40 years old, of mixed European, Native American and African ancestry, recruited in Latin America. Methods Skin ageing and mole count scores were obtained from facial photographs of over 6000 individuals. After quality control checks, three wrinkling traits and mole count were retained for genetic analyses. DNA samples were genotyped with Illumina's HumanOmniExpress chip. Association testing was performed on around 8 703 729 single-nucleotide polymorphisms (SNPs) across the autosomal genome.

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Section: Discussionmentioning

confidence: 88%

A genome‐wide association study identifies novel gene associations with facial skin wrinkling and mole count in Latin Americans

et al. 2021

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“…Whereas chronologic aging primarily presents with fine wrinkles, soft tissue volume loss, and increased skin laxity, photoaging is more likely to present with coarse wrinkles, telangiectasias, solar lentigines, mottled hyperpigmentation, and skin dullness [ 46 , 47 ]. Due to protection by epidermal melanin, individuals with SOC develop wrinkles from sun exposure later in life than those with lighter skin [ 23 , 52 – 55 ]. Nevertheless, histological evidence of solar elastosis in sun-exposed skin has been observed in Hispanics [ 56 ], Asians [ 39 ], and African Americans [ 57 , 58 ].…”

Section: Photoagingmentioning

confidence: 99%

“…In addition to wrinkling, photoaging commonly manifests in Asians as pigmented spots, solar lentigines, and pigmented seborrheic keratoses [ 39 , 52 , 53 , 59 ]. In African Americans, photoaging is associated with hyperpigmentation, dyschromia, increased skin laxity, and dermatosis papulosa nigra [ 55 ]. Hispanics often show significant heterogeneity in skin types, and predominant signs of photoaging may exist on a gradient between those commonly seen in light- and dark-skinned individuals [ 47 , 55 ].…”

Section: Photoagingmentioning

confidence: 99%

Photoprotection for Skin of Color

Tsai

Chien

2022

Am J Clin Dermatol

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Photoprotection behaviors can mitigate skin damage caused by ultraviolet radiation, and common methods include seeking shade, avoiding sun exposure during peak daylight hours, wearing sun-protective clothing, applying sunscreen, and using sunglasses. While the role of sun protection in preventing sunburns, photoaging, and skin cancer is well established in fair-skinned populations, individuals with skin of color (SOC) are presumed to suffer fewer negative effects from solar radiation. Thus, the importance of photoprotection in this population is understudied and may be underestimated. In SOC populations, sun exposure is known to cause pigmentary disorders, photoaging, and basal cell carcinoma (BCC), highlighting the potential benefits of photoprotection. Although SOC populations tend to practice photoprotection by seeking shade and wearing sun-protective clothing, survey and interview-based studies have consistently found relatively low use of sunscreen among these populations. Common motivators for photoprotection in individuals with SOC include preventing sunburn and pigmentation, with the prevention of skin cancer being a less important reason. As a skin cancer risk behavior, indoor tanning is relatively rare in SOC populations, but its use may increase with acculturation to US norms. While more studies are necessary to clarify whether photoprotection behaviors may decrease skin cancer-related mortality in SOC populations, regular dermatologic care and counseling on photoprotection remain essential in patients with SOC for overall skin health.

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“… 53 Other factors contributing to aging include progressive reduction in cell number and function, including in melanocytic and Langerhans cells, and decreases in hormones that impact skin physiology. 9 …”

Section: Facial Aging By Layersmentioning

confidence: 99%

The Facial Aging Process From the “Inside Out”

Swift

Liew²,

Weinkle

et al. 2020

Aesthetic Surgery Journal

153

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The normal course of aging alters the harmonious, symmetrical, and balanced facial features found in youth, not only impacting physical attractiveness but also influencing self-esteem and causing miscommunication of affect based on facial miscues. This evidence-based paper aims to provide a comprehensive overview of the latest research on the etiology and progression of facial aging by explaining the aging process from the “inside out”; that is, from the bony platform to the skin envelope. A general overview of the changes occurring within each of the main layers of the facial anatomy are presented, including remodeling of the facial skeleton, atrophy or repositioning of fat pads, changes in muscle tone and thickness, and weakening and thinning of the skin. This is followed by an in-depth analysis of specific aging regions by facial thirds (upper, middle, and lower thirds). This review may help aesthetic physicians in the interpretation of the aging process and in prioritizing and rationalizing treatment decisions to establish harmonious facial balance in younger patients or to restore balance lost with age in older patients.

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Aging in skin of color

Cited by 50 publications

References 29 publications

A genome‐wide association study identifies novel gene associations with facial skin wrinkling and mole count in Latin Americans

A genome‐wide association study identifies novel gene associations with facial skin wrinkling and mole count in Latin Americans

Photoprotection for Skin of Color

The Facial Aging Process From the “Inside Out”

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