Aging is an Inevitable Risk Factor for Insulin Resistance “Arabic Abstracts”

Refaie, Mohamed R.; Sayed‐Ahmed, Nagy; Bakr, Ataa M.; Aziz, Mohamed Yaqoot Abdel; Kannishi, Mohamed H. El; Abdel-Gawad, Soma S.

doi:10.1016/s1658-3612(06)70016-6

Cited by 2 publications

(4 citation statements)

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“…Improvements in glucose metabolism following bodyweight dissipation and exercise/training may be attributable to alterations in body composition and decrement in total and central body fat. Additional alterations in skeletal muscle [30], blood flow and certain mechanisms possibly interact in the modification of insulin resistance with exercise training. Lifestyle changes, bodyweight excoriation and physical activity are functional and beneficial health provisions [40,41] for the enhancement of insulin sensitivity and prevention of glucose intolerance and type 2 diabetes during ageing.…”

Section: Methods In the Investigation Of Ageing On Insulinmentioning

confidence: 99%

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Ageing and Insulin: Inter Alia Diabetes, Obesity and Fitness Concerns

Chukwuma¹

2023

Middle East Res J Pharm Sci

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This article argues the essence of insulin sensitivity versus secretion including insulin resistance in the clinical strategy for the treatment, lifestyle changes, prompt interventions and control of diabetes. Progressive decline of glucose tolerance as advanced age occurs has been associated with the pathogenesis of type 2 diabetes due to peripheral insulin resistance and impaired β cell function. In elderly persons, insulin secretion is deranged concomitantly with decreased insulin clearance rate and augmented circulating proinsulin level that ostensibly explicates age-related hyperglycemia. Insulin is associated with numerous pathophysiological processes exhibited during brain function in learning and memory, as well as the regulation of ageing, metabolic syndrome, obesity, diabetes and cardiovascular diseases in Man. Elevated chronic peripheral insulin, decreased insulin action and brain insulin contents are pathognomonic of the insulin resistance syndrome. All these are associated through specific mechanisms in the pathophysiology of ageing and insulin in concert with risk factors and the concomitant complications. Ostensibly, progressive excess insulin induces synchronous elevated levels of oxidative stress and inflammatory impacts which exacerbate or are exacerbated by advancing age, culminating as inimical consequences to healthy lifestyles, longevity or extended lifespan. Therapeutics and other healthcare measures may be beneficial in order to prevent, mitigate or amend insulin aberrations in the elderly and during the ageing process. The mainstay in managing an elderly patient with perturbed insulin action, is control of therapeutic application, as it can reverse acute terminal states. Treatment necessitates stringent and thorough expertise, knowledge and skills for optimum provision and effective cerebral, cardiovascular and skeletal protection for a healthier lifespan and longevity. This article will be of immense contribution in the understanding of the prevention, control and treatment of insulin resistance, metabolic syndrome, diabetes, obesity, cardiovascular and neurological disorders during ageing.

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Section: Methods In the Investigation Of Ageing On Insulinmentioning

confidence: 99%

“…The life elongation impact due to calorie restriction relates to IGF-1 decrement. It is suggested that antidiabetic biguanides are pertinent for both life span prolongation and cancer prevention [30].…”

Section: Neurodegenerative Disorders and Tumoursmentioning

confidence: 99%

Ageing and Insulin: Inter Alia Diabetes, Obesity and Fitness Concerns

Chukwuma¹

2023

Middle East Res J Pharm Sci

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“…An investigation on disparate states of glucose homeostasis in elderly patients as compared to healthy young subjects and young patients with type 2 diabetes intravenous glucose tolerance test suggested that insulin resistance was characteristic of conventional ageing trajectory; with senility as a consequential or invarible risk factor for glucose intolerance and metabolic syndrome with its consequential complications [12]. Insulin secretion and insulin clearance as well as insulin and target tissue interactions were impaired in elderly patients.…”

Section: Insulin Resistance Syndrome and Ageingmentioning

confidence: 99%

“…Insulin secretion and insulin clearance as well as insulin and target tissue interactions were impaired in elderly patients. These functionalities are intermediate between healthy and type 2 diabetic subjects, with predilection of the elderly general population for the risk of deranged glucose tolerance or diabetes with its concomitant vascular sequelae [12].…”

Section: Insulin Resistance Syndrome and Ageingmentioning

confidence: 99%

Insulin and Ageing: Interventions for Healthier Lifestyle and Prolonged Lifespan

Chukwuma

2023

JBRR

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Insulin has effects on ageing and lifespan, and provides a mechanism for gene manipulations for people to have prolonged and healthier lives. In addition, preserved insulin sensitivity is associated with longevity. Certain models of deranged insulin signaling are associated with prolonged longevity or resistance to life-threatening factors, such as oxidative stress. Insulin and insulin signaling are associated with successful ageing and longevity. Calorie restriction enhances lifespan in numerous species. Adequate control of factors associated with risks for obesity, diabetes, cardiovascular disease, and other insulin and ageing sequelae can be retarded in the elderly with optimum sustenance of their lifestyles.

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Aging is an Inevitable Risk Factor for Insulin Resistance “Arabic Abstracts”

Cited by 2 publications

References 0 publications

Ageing and Insulin: Inter Alia Diabetes, Obesity and Fitness Concerns

Ageing and Insulin: Inter Alia Diabetes, Obesity and Fitness Concerns

Insulin and Ageing: Interventions for Healthier Lifestyle and Prolonged Lifespan

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