Aging-like physiological changes in the skin of Japanese obese diabetic patients

Abstract

Objective:Obesity-associated diabetes causes aging-like changes to skin physiology in animal models, but there have been no clinical studies focusing on human obese diabetic patients. The purpose of this study was to examine the hypothesis that obesity-associated diabetes accelerates aging-like skin changes in Japanese people.Methods:This cross-sectional study enrolled obese-diabetes patients (body mass index ≥ 25 kg m−2) and healthy volunteers (body mass index < 25 kg m−2) as controls. Skin physiology parameters relating to aging (stratum corneum hydration, transepidermal water loss, skin pH, advanced glycation end-products, and dermal collagen density) were evaluated in the two groups.Results:About 37 subjects participated (16 in a control group and 21 in an obese-diabetes group). Age was not significantly different between the groups. The stratum corneum hydration level was significantly lower in the obese-diabetes group. Transepidermal water loss and levels of advanced glycation end-products were significantly higher in this group. Skin pH was not significantly different between groups. Dermal collagen density decreased in the obese-diabetes group.Conclusion:We showed that obese-diabetes patients have decreased stratum corneum hydration, increased transepidermal water loss, higher skin advanced glycation end-products and decreased dermal collagen fiber density compared with normal-weight subjects. These results indicate that the ordinary age-related physiological skin changes seen in the elderly can also occur in obese-diabetes patients aged in their 40s.

<p>Topical effects of SCA^&reg; (<em>Cryptomphalus aspersa</em> secretion) associated with regenerative and antioxidant ingredients on aged skin: evaluation by confocal and clinical microscopy</p>

“…The antioxidant and repairing effects of ingredients in combination can protect and even reduce the impact of environmental damage, but also of the oxidative effects caused by habit-related factors; the studied sample shows that almost 70% of the women are overweight or obese, data that coincide with the incidence found in the literature,27,28 an oxidative factor that is also capable of promoting changes related to skin aging 29–31…”

The effect of aging in primary human dermal fibroblasts

“…It frequently experiences the direct effects of environmental exposure, including UV radiation and air pollution [1]. Alterations in skin structure and physiology occur as natural consequences of aging and contribute to diminished cutaneous health [2; 3; 4]. These damages can be aggravated by external factors and, combined with lifestyle, result in significant biological alterations, characteristic of premature aging [5; 6; 7].…”

Skin Aging & Modern Age Anti-aging Strategies

“…Ibuki et.al, 2017 reported that obese-diabetes patients have decreased stratum corneum hydration, increased transepidermal water loss, higher skin advanced glycation end-products and decreased dermal collagen fiber density compared with normal-weight subjects. These results indicate that the ordinary age-related physiological skin changes seen in the elderly can also occur in obese-diabetes patients aged in their 40s [48].…”