Aging Men and Lipids

Abstract

Many theories aim at explaining the mechanisms of aging and death in humans. Decreased levels of androgens, growth hormone, and insulin-like growth factor accompany natural aging in men. Androgens influence the growth and maturation of men in various stages of their life. The action of androgens is performed by binding or not binding to androgen receptors. However, various actions of androgens were clarified after the discovery and genotyping of the androgen receptor. The influence of androgens on the lipid profile was reported by several researchers. This negative influence of androgens in men and the positive influence of estrogens in women are responsible for the higher impact of atherogenesis in men compared with women. In aging men, this negative influence of androgens on the lipid profile is more pronounced. This review considers the influence of age on lipid metabolism in men.

Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations

“…The mTOR pathway is highly conserved and regulates processes including protein synthesis, lipid metabolism, glycolysis, angiogenesis, apoptosis, inflammation and autophagy (Proud, 2011) (Figure 1). Increasing age has been associated with perturbations to most of these factors; decreases in protein synthesis with age are well documented in various tissues in man and animal models (Kennedy and Kaeberlein, 2009), whereas age-related increases to lipid profiles (AbouRjaili et al, 2010; Kolovou et al, 2011) and inflammatory processes (Chung et al, 2011) have also been reported.…”

Validity and reliability of male andropause symptoms self-assessment questionnaire among elderly males in Khuzestan province of Iran

“…The results stated to the well-adjusted reliability and validity of MASSQ and usefulness of it in the relevant studies as well. Therefore, future researchers should not limit themselves to the western scales[720] but should also consider specific cultural factors. Additionally, it is suggested that in future studies, the female menopause symptoms self-assessment questionnaire, which are compatible with Iran's native culture, be conducted and evaluated as well.…”

“…The MASSQ questionnaire mainly consists of a 25-item disability/symptom scale regarding andropause that was investigated by authors and literature reviews. [24712192123262834] Each item in the disability/symptom scale has five response options from 1 = none to 5 = extremely severe. If the 25 items are completed, a scale score ranging from 25 (no symptoms) to 125 (most severe symptoms) can be calculated.…”

“…Ignorance and fear of the andropause condition abounds in the general public[12] and even among health professionals. [34567] Over 10,000 articles on climacteric (or menopause) for women can be found but relatively less has been conducted on the male equivalent. [8910] The ratio of published studies of menopausal men to menopausal women is approximately 1:100.…”

The role of eggs in the diet: nutraceutical and epigenetic aspects

“…94 nonostante siano ancora poco chiari i meccanismi sui quali gli ω3 intervengono, autorità sanitarie in vari paesi hanno recentemente raccomandato la produzione di alimenti, in particolare uova, yogurt, latte, arricchiti con tali acidi grassi per aumentarne l'assunzione. 93,95 Attualmente l'American heart Association ha definito auspicabile l'assunzione di acidi grassi ω3 con almeno due porzioni alla settimana di pesce e utilizzando oli vegetali ricchi di acido α-linolenico (canola, soia, ecc.). Per i pazienti con documentato rischio cardiovascolare, suggerisce, inoltre, un apporto di circa 1 g al giorno di ePA e dhA, provenienti da pesci grassi o da integratori alimentari.…”