2008
DOI: 10.4049/jimmunol.181.11.7977
|View full text |Cite
|
Sign up to set email alerts
|

Aging Mice Exhibit a Functional Defect in Mucosal Dendritic Cell Response against an Intracellular Pathogen

Abstract: Down-regulation of the immune response in aging individuals puts this population at a potential risk against infectious agents. In-depth studies conducted in humans and mouse models have demonstrated that with increasing age, the T cell immune response against pathogens is compromised and response to vaccinations is subdued. In the present study, using a mouse model, we demonstrate that older animals exhibit greater susceptibility to Encephalitozoon cuniculi infection, and their ability to evoke an Ag-specific… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
79
1

Year Published

2009
2009
2024
2024

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 92 publications
(84 citation statements)
references
References 55 publications
4
79
1
Order By: Relevance
“…Indeed, others showed that DCs activated in vitro by IL-15 effectively restored T cell function against an intracellular pathogen in aged mice (40). Our previous study showed that an increased frequency of DCs within the T cell and the subepithelial regions of NALT played a key role in the induction of Ag-specific T cell and Ab responses (17,19,27).…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, others showed that DCs activated in vitro by IL-15 effectively restored T cell function against an intracellular pathogen in aged mice (40). Our previous study showed that an increased frequency of DCs within the T cell and the subepithelial regions of NALT played a key role in the induction of Ag-specific T cell and Ab responses (17,19,27).…”
Section: Discussionmentioning
confidence: 99%
“…Due to the effect of estrogen on DCs, there may be differences in DC percentages and total cell numbers between sexes of animals (36,37), but our data show few gender differences. In addition, animal age has been shown to modify DC populations (38,39). Finally, the strain of the animal may also affect the percent and total DC numbers (40).…”
Section: Discussionmentioning
confidence: 99%
“…Considering that opportunistic infections are more prevalent in older HIV + patients (13), there is an urgent need to understand the mechanistic basis of susceptibility to Microsporidia in aging individuals. A previous study from our laboratory demonstrated that, similar to humans, aging mice exhibit elevated susceptibility to this infection that was coincident with progressive decline in the systemic response of CD8 + T cells, a subset critical for protection against this pathogen (14). While in vitro studies suggested that dendritic cells were a mod-est contributor to this process, the mechanistic basis of poor CD8 + T cell response in aged mice remains underexplored (14,15).…”
Section: Introductionmentioning
confidence: 99%