Aging of hair follicle stem cells and their niches

Jang, Hansaem; Jo, Yemin; Lee, Jung Hyun; Choi, Sekyu

doi:10.5483/bmbrep.2022-0183

Cited by 18 publications

(8 citation statements)

References 101 publications

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“…Details about the different factors contributing to this have been reviewed recently. 41 In humans, it is well known that genetic risk factors contribute to the development of androgenic alopecia. 14,33 A well-known example for the adaptation of the hair coat to environmental factors is the seasonal changes of the hair coat.…”

Section: Systemic and Environmental Influences On The Hcmentioning

confidence: 99%

“…looking at skin biopsies from dogs and horses are in agreement that the anagen peaks in autumn and spring and a higher percentage of telogen follicles is seen in summer and winter. 4,5,13,41,55,75,76,79,80…”

Section: The Hcmentioning

confidence: 99%

Section: The Hcmentioning

confidence: 99%

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Basic principles of hair follicle structure, morphogenesis, and regeneration

Welle

2023

Vet Pathol

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Diseases affecting the hair follicle are common in domestic animals, but despite the importance of an intact skin barrier and a fully functional hair coat, knowledge about the detailed morphological features and the diversity of these complex mini-organs are often limited, although mandatory to evaluate skin biopsies with a history of alopecia. The factors that regulate the innate hair follicle formation and the postnatal hair cycle are still not completely understood in rodents, only rudimentarily known in humans, and are poorly understood in our companion animals. This review aims to summarize the current knowledge about hair follicle and hair shaft anatomy, the arrangement of hair follicles, hair follicle morphogenesis in the embryo, and the lifelong regeneration during the postnatal hair cycle in domestic animals. The role of follicular stem cells and the need for a multitude of interacting signaling events during hair follicle morphogenesis and regeneration is unquestioned. Because of the lack of state of the art methods that can be applied in rodents but are not feasible in companion animals, most of the information in this review is based on rodent studies. However, the few data from domestic animals that are available will be discussed, and it can be assumed that at least the principal molecular mechanisms are similar in rodents and other species.

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Section: Systemic and Environmental Influences On The Hcmentioning

confidence: 99%

Section: The Hcmentioning

confidence: 99%

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Basic principles of hair follicle structure, morphogenesis, and regeneration

Welle

2023

Vet Pathol

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“…Finally, a new group of aging studies has also shown that aging can be associated with stem cell exhaustion. NIH researchers have shown that with aging, stem cells lose adhesions and start moving away from base of the follicle [ 31 , 32 ]. These studies were part of the overall aging process studies, and hair follicles were a good model for these studies.…”

Section: Reviewmentioning

confidence: 99%

Stem Cell Applications in Human Hair Growth: A Literature Review

Talebzadeh¹,

Talebzadeh²

2023

Cureus

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Stem cells are being investigated in applications in male pattern baldness and other forms of alopecia of the human scalp. This report explores the literature regarding the various applications of stem cells and their potential for future use in the correction of multifactorial etiologies for male or female pattern baldness. Different contemporary studies revealed that stem cells may be directly injected into the scalp to allow the growth of new hair follicles in males or females for the correction of alopecia. Stem cells may also be used in growth factor stimulation of existing inactive and atrophic follicles to yet again become viable and active follicles. Additional studies indicate that various regulatory mechanisms may be used to reinitiate the existing inactive follicle cells to regrow hair in male pattern baldness. Stem cells injected into the scalp could aid these regulatory mechanisms. In the future, stem cell treatment may serve as a viable option superior to the US Food and Drug Administration (FDA)-approved invasive and noninvasive techniques currently used to combat alopecia.

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“…But how exactly does it cause hair follicle regeneration? In fact, telomere shortening impairs the mobilization and proliferation of HFSCs, exhibiting a follicle aging phenotype of thinner hair, hair loss, or gray hair, 28 which may be due to the corresponding negative effects on DPCs and HF melanocytes. Overexpression of TERT or reintroduction of telomerase can reverse this defect, activate quiescent HFSCs and melanocyte stem cells, fight HF aging, and facilitate HF regeneration 29 …”

Section: Telomerase Activation Positively Promotes Hair Growthmentioning

confidence: 99%

The role of telomerase in hair growth and relevant disorders: A review

Wang,

Bi,

et al. 2023

J of Cosmetic Dermatology

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BackgroundHair diseases may present with hair loss, hirsutism, hair melanin abnormalities and other manifestations. Hair follicles are known as mini‐organs that undergo periodic remodeling, and their constant regeneration in vivo reflects interesting anti‐aging functions. Telomerase prevents cellular senescence by maintaining telomere length, but its excessive proliferation in cancer cells may also induce cancer. However, the effects of telomerase in hair growth have rarely been reported.MethodsIn this study, we reviewed the role of telomerase in hair growth and the effects of hair disorders through literature search and analysis.ResultsThere is growing evidence that telomerase plays an important role in maintaining hair follicle function and proliferation. Changes in telomerase levels in hair follicles have also been found in a variety of hair disorders.ConclusionTelomerase plays a positive role in hair growth and is expected to become a new target for the treatment of alopecia or other hair diseases in the future.

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Aging of hair follicle stem cells and their niches

Cited by 18 publications

References 101 publications

Basic principles of hair follicle structure, morphogenesis, and regeneration

Basic principles of hair follicle structure, morphogenesis, and regeneration

Stem Cell Applications in Human Hair Growth: A Literature Review

The role of telomerase in hair growth and relevant disorders: A review

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