Aging of the erythrocyte. XIX. Decrease in surface charge density of bovine erythrocytes

Bartosz, Grzegorz; Grzelińska, Ewa; Bartkowiak, Anna

doi:10.1016/0047-6374(84)90172-6

Cited by 11 publications

(2 citation statements)

References 23 publications

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“…The majority of authors found a slight but signif icant (about 10-15 %) age-related decrease in the amount of sialic acid residues per cell in several mammalian species [39,90,91], However, most of the careful studies indi cate that the slight decrease in the sialic acid content is due rather to the nonspecific loss of membrane material than to specific desialylation [32,92],…”

Section: Carbohydrate Compositionmentioning

confidence: 99%

Erythrocyte Aging: Physical and Chemical Membrane Changes

Bartosz¹

1991

Gerontology

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The mammalian erythrocyte is an interesting model for studies of membrane aging. Experimental approaches to this problem involve, first of all, comparison of properties of erythrocytes separated by density because red blood cell age correlates with density in principle. Other approaches to study red cell membrane aging, such as hypertransfusion, are also discussed. A number of physical and chemical changes occur in erythrocytes with aging. Crucial to the elucidation of aging mechanisms is to determine which are primary and which are secondary. Immunoglobulin G binding triggers cellular removal and seems necessary for the recognition of senescent erythrocytes. Cellular deformability decreases while fragility to hemolytic factors generally increases and surface charge density does not alter. Perhaps more important are reactions of reactive oxygen species with membrane constituents and subsequent proteolysis. These are implicated as causative factors in red cell aging, immunoglobulin binding and recognition of senescent erythrocytes.

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Section: Carbohydrate Compositionmentioning

confidence: 99%

Erythrocyte Aging: Physical and Chemical Membrane Changes

Bartosz¹

1991

Gerontology

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“…Some investigators have reported that old red cells showed decreases in mobility [12][13][14] and in membrane sialic acid content14-18) compared with young cells. Furthermore, erythrocyte deformability is important in the removal and subsequent destruction of abnormal or senescent RBCs from the circulation19,20).…”

Section: Introductionmentioning

confidence: 99%

Effects of Lead on Electrophoretic Mobility, Membrane Sialic Acid, Deformability and Survival of Rat Erythrocytes.

Terayama

1993

INDUSTRIAL HEALTH

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: The anemia frequently observed in lead poisoning is thought to result from the shortening of erythrocyte life span in combination with inhibition of hemoglobin synthesis.However, the exact mechanism by which lead shortens the life span of red blood cells (RBCs) remains unclear. In the present study, the effects of injected lead on electrophoretic mobility, membrane sialic acid content, deformability and survival of rat RBCs were investigated in order to clarify the relationships between them. As indices of lead exposure, RBC counts, hemoglobin (Hb) levels, hematocrits (Ht), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and blood lead (blood Pb) levels in the rats were also examined. Exposure to lead significantly decreased RBC counts, Hb levels, Ht, MCV and MCH. Similarly, exposure to lead significantly decreased the mobility, sialic acid content and deformability of rat RBCs. A shortening of erythrocyte survival time was also observed in the rats exposed to lead. It is speculated that decreases in membrane sialic acid content and deformability of RBCs induce a shortening of erythrocyte survival time in anemia caused by lead.

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Membrane Lipid Asymmetry in Aging and Apoptosis

Balasubramanian

Schroit

2011

Transmembrane Dynamics of Lipids

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Aging of the erythrocyte. XIX. Decrease in surface charge density of bovine erythrocytes

Cited by 11 publications

References 23 publications

Erythrocyte Aging: Physical and Chemical Membrane Changes

Erythrocyte Aging: Physical and Chemical Membrane Changes

Effects of Lead on Electrophoretic Mobility, Membrane Sialic Acid, Deformability and Survival of Rat Erythrocytes.

Membrane Lipid Asymmetry in Aging and Apoptosis

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