Aging of the frontal lobe

Zanto, Theodore P.; Gazzaley, Adam

doi:10.1016/b978-0-12-804281-6.00020-3

Cited by 86 publications

(72 citation statements)

References 259 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From this perspective, the seeming lack of retrieval gating in older adults might reflect an age-related decline in the frontallymediated control processes that have been proposed to downregulate the representation of intrusive and task-irrelevant information in other experimental settings (e.g. Zanto & Gazzaley, 2019;Zanto et al, 2011). This proposal is consistent with the broader literature linking age-related decline in executive control to reduced structural and functional integrity of prefrontal cortex (Buckner, 2004;Dennis & Cabeza, 2008;Tromp et al, 2015).…”

Section: Age Differences In the Control Of Cortical Reinstatementsupporting

confidence: 78%

Effects of age on goal-dependent modulation of episodic memory retrieval

Srokova

Hill

Elward

et al. 2021

Neurobiology of Aging

View full text Add to dashboard Cite

Retrieval gating refers to the ability to modulate the retrieval of features of a single memory episode according to behavioral goals. Recent findings demonstrate that younger adults engage retrieval gating by attenuating the representation of task-irrelevant features of an episode. Here, we examine whether retrieval gating varies with age. Younger and older adults incidentally encoded words superimposed over scenes or scrambled backgrounds that were displayed in one of three spatial locations. Participants subsequently underwent fMRI as they completed two memory tasks: the background task, which tested memory for the word's background, and the location task, testing memory for the word's location. Employing univariate and multivariate approaches, we demonstrated that younger, but not older adults, exhibited attenuated reinstatement of scene information when it was goal-irrelevant (during the location task). Additionally, in younger adults only, the strength of scene reinstatement in the parahippocampal place area during the background task was related to item and source memory performance. Together, these findings point to an agerelated decline in the ability to engage retrieval gating.

show abstract

Section: Age Differences In the Control Of Cortical Reinstatementsupporting

confidence: 78%

Effects of age on goal-dependent modulation of episodic memory retrieval

Srokova

Hill

Elward

et al. 2021

Neurobiology of Aging

View full text Add to dashboard Cite

show abstract

“…the right inferior frontal gyrus in patients with AIS. These brain regions are associated with cognitive function since several distinct cognitive and behavioral processes are reportedly mediated by them (Henri-Bhargava et al, 2018;Parnaudeau et al, 2018;Zanto and Gazzaley, 2019). Previous studies showed functional connectivity decrease in the left paracentral lobule, left middle frontal gyrus, and the right middle frontal gyrus in patients with vascular cognitive impairment (Sun et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Dengzhanxixin Injection Ameliorates Cognitive Impairment Through a Neuroprotective Mechanism Based on Mitochondrial Preservation in Patients With Acute Ischemic Stroke

Wan

Liang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Acute ischemic stroke (AIS) is a global health burden and cognitive impairment is one of its most serious complication. Adequate interventions for AIS may have the potential to improve cognitive outcomes. In the present study, we selected Erigeron breviscapus (Vaniot) Hand.-Mazz. injection (Dengzhanxixin injection, DZXI), a widely used Chinese herbal injection, in contrast to edaravone as the positive control drug to test its potential to ameliorates neurological and cognitive impairments caused by AIS. We performed a 2-week randomized trial with these two drugs in AIS patients presenting mild to moderate cognitive impairments. Neuropsychological tests and MRI examinations showed that DZXI attenuated the neurological and cognitive impairments of patients and protected the grey matter in specific regions from ischemic damage. Notably, DZXI exerted better effects than edaravone in some neuropsychological tests, probably due to the protective effect of DZXI on grey matter. To explore the therapeutic mechanisms, we carried out an experiment with a middle cerebral artery occlusion rat model. We found that DZXI decreased the infarct volume and increased the survival of neuronal cells in the ischemic penumbra; furthermore, DZXI modulated the mitochondrial respiratory chain process and preserved the mitochondrial structure in the brain tissue. Overall, our data suggested that the administration of DZXI is effective at ameliorating neurological and cognitive impairments in AIS, and the underlying mechanisms are related to the protective effects of DZXI on cerebral neurons and neuronal mitochondria.

show abstract

“…Indeed, many studies provided evidence for an age‐related decline in executive functions, among other domains, showing that healthy older adults perform poorer than the younger counterparts on executive function tasks documenting for instance working memory deficits, reduced inhibitory control, and decreased task‐switching ability (MacPherson et al., 2015 ; West, 1996 ; Zanto & Gazzaley, 2019 ; but see Vallesi et al., 2021 ). As EEG‐NFT could be a potentially effective method to counteract this age‐related executive function decline, we assessed whether, to date, studies have provided reliable evidence for its effectiveness.…”

Section: Introductionmentioning

confidence: 99%