Aging of the Lungs in Asymptomatic Lifelong Nonsmokers: Findings on HRCT

Winter, Daniel Hugo; Manzini, Marcos; Salge, João Marcos; Jaluul, Omar; Mathias, Wilson; Terra-Filho, Mário

doi:10.1007/s00408-015-9700-3

Cited by 46 publications

(36 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the studies by Copley et al 3 and Winter et al 4 with relatively small numbers of subjects, only the elderly groups (older than 65 or 75 years) had pulmonary cysts. The present study of a large population-based cohort revealed that pulmonary cysts can be seen even in middle-aged participants as young as 40 years.…”

Section: Discussionmentioning

confidence: 93%

“…In addition, our study involved a direct comparison of the groups with emphysema and pulmonary cysts separately diagnosed on CT and revealed that these two entities occur independently. In the previous studies, it was not possible to discuss the association between age-related pulmonary cysts and emphysema because the presence of chronic lung diseases including emphysema was a part of exclusion criteria 3 4 6 17. Furthermore, some other findings also bolster the fact that pulmonary cysts are a distinct entity from emphysema: pulmonary cysts are not associated with smoking and tend to occur with the lower lobe predilection with no sex difference and no impairment of measures of spirometry, whereas emphysema predominantly occurs in the upper lobes, in male smokers 18.…”

Section: Discussionmentioning

confidence: 99%

“…In a study by Copley et al ,3 pulmonary cysts were seen on CT in 25% (10/40) of individuals older than 75 years but in no individuals younger than 55 years (0/16). More recently, Winter et al 4 also reported pulmonary cysts were seen in 13% (6/47) of individuals older than 65 years but none in those aged 30–50 years (0/24). These studies suggest that asymptomatic pulmonary cysts could be a part of the aging processes.…”

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

Pulmonary cysts identified on chest CT: are they part of aging change or of clinical significance?

Araki

Nishino

Gao

et al. 2015

Thorax

View full text Add to dashboard Cite

Objective To investigate the prevalence and natural course of pulmonary cysts in a population-based cohort and to describe the CT image characteristics in association with participant demographics and pulmonary functions. Materials and Methods Chest CT scans of 2633 participants (mean 59.2 years; 50% female) of the Framingham Heart Study (FHS) were visually evaluated for the presence of pulmonary cysts and their image characteristics. These findings were correlated with participant demographics and results of pulmonary function tests as well as the presence of emphysema independently detected on CT. The interval change was investigated by comparison with previous CT scans (median interval, 6.1 years). Results Pulmonary cysts were seen in 7.6% (95% CI, 6.6-8.7; 200/2633). They were not observed in participants younger than 40 years old, and the prevalence increased with age. Multiple cysts (≥5) were seen in 0.9% of all participants. Participants with pulmonary cysts showed significantly lower BMI (P<0.001). Pulmonary cysts were most likely to appear solitary in the peripheral area of the lower lobes and remain unchanged or slightly increase in size over time. Pulmonary cysts showed no significant influence on pulmonary functions (P=0.07-0.6) except for DLCO (P=0.03) and no association with cigarette smoking (P=0.1-0.9) or emphysema (P=0.7). Conclusions Pulmonary cysts identified on chest CT may be a part of the aging changes of the lungs, occurring in asymptomatic individuals older than 40 years, and are associated with decreased BMI and DLCO. Multiple pulmonary cysts may need to be evaluated for the possibility of cystic lung diseases.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Pulmonary cysts identified on chest CT: are they part of aging change or of clinical significance?

Araki

Nishino

Gao

et al. 2015

Thorax

View full text Add to dashboard Cite

show abstract

“…Radiological bronchiectasis may be a common finding in the asymptomatic elderly or may be an incidental finding in other respiratory disorders such as COPD [24–26]. For the avoidance of doubt, patients with radiological bronchiectasis but without clinical symptoms and a physician diagnosis of clinically significant bronchiectasis will not be included in the study.…”

Section: Methods and Design Of The Embarc Registrymentioning

confidence: 99%

The EMBARC European Bronchiectasis Registry: protocol for an international observational study

et al. 2016

View full text Add to dashboard Cite

Bronchiectasis is one of the most neglected diseases in respiratory medicine. There are no approved therapies and few large-scale, representative epidemiological studies.The EMBARC (European Multicentre Bronchiectasis Audit and Research Collaboration) registry is a prospective, pan-European observational study of patients with bronchiectasis. The inclusion criterion is a primary clinical diagnosis of bronchiectasis consisting of: 1) a clinical history consistent with bronchiectasis; and 2) computed tomography demonstrating bronchiectasis. Core exclusion criteria are: 1) bronchiectasis due to known cystic fibrosis; 2) age <18 years; and 3) patients who are unable or unwilling to provide informed consent.The study aims to enrol 1000 patients by April 2016 across at least 20 European countries, and 10 000 patients by March 2020. Patients will undergo a comprehensive baseline assessment and will be followed up annually for up to 5 years with the goal of providing high-quality longitudinal data on outcomes, treatment patterns and quality of life. Data from the registry will be available in the form of annual reports. and will be disseminated in conference presentations and peer-reviewed publications.The European Bronchiectasis Registry aims to make a major contribution to understanding the natural history of the disease, as well as guiding evidence-based decision making and facilitating large randomised controlled trials.

show abstract

“…5). [37][38][39][40] The frequency and extent of air-trapping (an indirect CT feature of small airways disease) significantly increased with age in a prospective study by Lee et al, 40 but relatively few over 75 years olds were included. 34 Airways Multiple CT studies have described both large and small airway "abnormalities" in apparently healthy older individuals.…”

Section: Ct Parenchymal and Airway Features Described In Older Peoplementioning

confidence: 99%

Morphology of the Aging Lung on Computed Tomography

Copley¹

2016

Journal of Thoracic Imaging

View full text Add to dashboard Cite

As the population becomes older, recognition of the pulmonary computed tomography (CT) features of "normal" aging is likely to become increasingly important to differentiate from clinically significant disease. Several studies have evaluated the appearances of the lung parenchyma and large and small airways in asymptomatic older individuals and found increased prevalence of cysts, reticular pattern, air trapping, bronchial dilation, and bronchial wall thickening in older individuals compared with younger individuals. Objective differences in CT lung parenchymal attenuation and complexity have also been described. The CT appearances of the aging lung are illustrated, and the histopathologic and functional changes are discussed.

show abstract

Aging of the Lungs in Asymptomatic Lifelong Nonsmokers: Findings on HRCT

Abstract: Parenchymal bands, ground-glass opacities, septal lines, bronchiectasis, micronodules, reticular opacities, and lung cysts were more prevalent among the elderly.

Cited by 46 publications

References 28 publications

Pulmonary cysts identified on chest CT: are they part of aging change or of clinical significance?

Pulmonary cysts identified on chest CT: are they part of aging change or of clinical significance?

The EMBARC European Bronchiectasis Registry: protocol for an international observational study

Morphology of the Aging Lung on Computed Tomography

Contact Info

Product

Resources

About