Aging ovary and the role for advanced glycation end products

Pertyńska−Marczewska, Magdalena; Diamanti-Kandarakis, Evanthia

doi:10.1097/gme.0000000000000755

Cited by 43 publications

(25 citation statements)

References 74 publications

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“…Other studies have shown that the follicular fluid of aged women has lower glutathione peroxidase and superoxide dismutase levels [102,103]. Advanced glycation end products (AGEs) are also closely related to declining ovarian function as the accumulation of AGEs contributes directly to protein damage, induces a chain of oxidative stress reactions, and increases inflammatory reactions, thereby inducing a premature decline in ovarian function [104,105]. The external environment may affect aging by regulating key metabolic sensors (e.g., SIRT1 and AMPK), which interact with the mammalian target of rapamycin and insulin/insulin-like growth factor 1 (IGF-1) to control energy metabolism and cell growth.…”

Section: Aging Causes Metabolic Disorders In the Ovariesmentioning

confidence: 99%

The Molecular Regulation in the Pathophysiology in Ovarian Aging

Lin

Tsai

et al. 2021

Aging and disease

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The female reproductive system is of great significance to women's health. Aging of the female reproductive system occurs approximately 10 years prior to the natural age-associated functional decline of other organ systems. With an increase in life expectancy worldwide, reproductive aging has gradually become a key health issue among women. Therefore, an adequate understanding of the causes and molecular mechanisms of ovarian aging is essential towards the inhibition of age-related diseases and the promotion of health and longevity in women. In general, women begin to experience a decline in ovarian function around the age of 35 years, which is mainly manifested as a decrease in the number of ovarian follicles and the quality of oocytes. Studies have revealed the occurrence of mitochondrial dysfunction, reduced DNA repair, epigenetic changes, and metabolic alterations in the cells within the ovaries as age increases. In the present work, we reviewed the possible factors of aging-induced ovarian insufficiency based on its clinical diagnosis and performed an in-depth investigation of the relevant molecular mechanisms and potential targets to provide novel approaches for the effective improvement of ovarian function in older women.

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Section: Aging Causes Metabolic Disorders In the Ovariesmentioning

confidence: 99%

The Molecular Regulation in the Pathophysiology in Ovarian Aging

Lin

Tsai

et al. 2021

Aging and disease

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“…This decline has various causes. For instance, it can result from oxidative stress along with glycation processes [ 5 ] or mitochondrial aging. [ 6 ] Epigenetic alterations are also expected to have an impact on ovarian aging.…”

Section: Figurementioning

confidence: 99%

Predictable increase in female reproductive window: A simple model connecting age of reproduction, menopause, and longevity

2021

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With the ever-increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter-selection of such deleterious alleles. In reviewing this field, we speculate that a logical consequence would be the later occurrence of menopause and the extension of women's reproductive lifespan.We illustrate this point with a simple model that applies to other variants that contribute to female infertility, including epigenetic variation. We also consider the effect of medical interventions and lifestyle.

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“…The human female reproductive axis typically declines quickly in women after the age of 35. Since, as in other organs, free radical damage contributes to diminished reproductive processes including the onset of menopause [203,204], the antioxidant melatonin has been tested for its potential in deferring the slowed follicular maturation and reduced oocyte quality observed in the aging female. The results of these studies verify that melatonin has significant benefits in maintaining the function of the ovary and adnexa which normally deteriorates with age or after exposure to toxins, etc.…”

Section: The Melatonin/sirt3 Interactionsmentioning

confidence: 99%

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

Reíter

Tan

Rosales-Corral

et al. 2018

IJMS

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Melatonin exhibits extraordinary diversity in terms of its functions and distribution. When discovered, it was thought to be uniquely of pineal gland origin. Subsequently, melatonin synthesis was identified in a variety of organs and recently it was shown to be produced in the mitochondria. Since mitochondria exist in every cell, with a few exceptions, it means that every vertebrate, invertebrate, and plant cell produces melatonin. The mitochondrial synthesis of melatonin is not photoperiod-dependent, but it may be inducible under conditions of stress. Mitochondria-produced melatonin is not released into the systemic circulation, but rather is used primarily in its cell of origin. Melatonin’s functions in the mitochondria are highly diverse, not unlike those of sirtuin 3 (SIRT3). SIRT3 is an NAD+-dependent deacetylase which regulates, among many functions, the redox state of the mitochondria. Recent data proves that melatonin and SIRT3 post-translationally collaborate in regulating free radical generation and removal from mitochondria. Since melatonin and SIRT3 have cohabitated in the mitochondria for many eons, we predict that these molecules interact in many other ways to control mitochondrial physiology. It is predicted that these mutual functions will be intensely investigated in the next decade and importantly, we assume that the findings will have significant applications for preventing/delaying some age-related diseases and aging itself.

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Aging ovary and the role for advanced glycation end products

Abstract: Further investigation of the role for the AGE-RAGE axis in the ovarian follicular environment is needed, and results could relate to assisted reproduction technology outcomes and new measures of ovarian reserve.

Cited by 43 publications

References 74 publications

The Molecular Regulation in the Pathophysiology in Ovarian Aging

The Molecular Regulation in the Pathophysiology in Ovarian Aging

Predictable increase in female reproductive window: A simple model connecting age of reproduction, menopause, and longevity

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

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