Aging‐Related Decline of Gonadal Function in Healthy Men: Correlation with Body Composition and Lipoproteins

Denti, Licia; Pasolini, G.; Sanfelici, Laura; Benedetti, Raffaella; Cecchetti, Alessandra; Ceda, Gian Paolo; Ablondi, F.; Valenti, Giorgio

doi:10.1111/j.1532-5415.2000.tb03028.x

Cited by 58 publications

(33 citation statements)

References 44 publications

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“…In contrast to these studies, however, Khaw et al (2007) reported that LDL levels were increased in patients in the upper quartile of endogenous testosterone levels compared with the lower quartile, yet a positive association between HDL and testosterone level was apparent. A few cross-sectional studies, however, have found no association between serum lipid measurements and endogenous testosterone (Kiel et al 1989, Denti et al 2000.…”

Section: Testosterone Effects On Lipidsmentioning

confidence: 99%

Testosterone: a metabolic hormone in health and disease

Kelly

Jones

2013

Journal of Endocrinology

440

330

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Testosterone is a hormone that plays a key role in carbohydrate, fat and protein metabolism. It has been known for some time that testosterone has a major influence on body fat composition and muscle mass in the male. Testosterone deficiency is associated with an increased fat mass (in particular central adiposity), reduced insulin sensitivity, impaired glucose tolerance, elevated triglycerides and cholesterol and low HDL-cholesterol. All these factors are found in the metabolic syndrome (MetS) and type 2 diabetes, contributing to cardiovascular risk. Clinical trials demonstrate that testosterone replacement therapy improves the insulin resistance found in these conditions as well as glycaemic control and also reduces body fat mass, in particular truncal adiposity, cholesterol and triglycerides. The mechanisms by which testosterone acts on pathways to control metabolism are not fully clear. There is, however, an increasing body of evidence from animal, cell and clinical studies that testosterone at the molecular level controls the expression of important regulatory proteins involved in glycolysis, glycogen synthesis and lipid and cholesterol metabolism. The effects of testosterone differ in the major tissues involved in insulin action, which include liver, muscle and fat, suggesting a complex regulatory influence on metabolism. The cumulative effects of testosterone on these biochemical pathways would account for the overall benefit on insulin sensitivity observed in clinical trials. This review discusses the current knowledge of the metabolic actions of testosterone and how testosterone deficiency contributes to the clinical disease states of obesity, MetS and type 2 diabetes and the role of testosterone replacement.

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Section: Testosterone Effects On Lipidsmentioning

confidence: 99%

Testosterone: a metabolic hormone in health and disease

Kelly

Jones

2013

Journal of Endocrinology

440

330

View full text Add to dashboard Cite

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“…The age trend of serum estrogen in men has been reported variously as declining (8,35) or steady (61). Estrogens were invariant with age in the baseline MMAS (9).…”

Section: Hormone Trendsmentioning

confidence: 99%

“…T and DHEA decline with age, whereas LH, FSH, and sex hormone-binding globulin (SHBG) rise with age (3)(4)(5)(6)(7)(8)(9). At least one important T metabolite, dihydrotestosterone (DHT), apparently remains constant despite the decline of its precursor (9 -12).…”

mentioning

confidence: 99%

Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study

Feldman

Longcope

Derby

et al. 2002

The Journal of Clinical Endocrinology & Metabolism

1,383

599

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We used longitudinal data from the Massachusetts Male Aging Study, a large population-based random-sample cohort of men aged 40 -70 yr at baseline, to establish normative age trends for serum level of T and related hormones in middle-aged men and to test whether general health status affected the age trends. Of 1,709 men enrolled in 1987-1989, 1,156 were followed up 7-10 yr afterward. By repeated-measures statistical analysis, we estimated simultaneously the cross-sectional age trend of each hormone between subjects within the baseline data, the cross-sectional trend between subjects within the follow-up data, and the longitudinal trend within subjects between baseline and follow-up.Total T declined cross-sectionally at 0.8%/yr of age within the follow-up data, whereas both free and albumin-bound T declined at about 2%/yr, all significantly more steeply than within the baseline data. Sex hormone-binding globulin increased cross-sectionally at 1.6%/yr in the follow-up data, similarly to baseline. The longitudinal decline within subjects between baseline and follow-up was considerably steeper than the cross-sectional trend within measurement times for total T (1.6%/yr) and bioavailable T (2-3%/yr). Dehydroepiandrosterone, dehydroepiandrosterone sulfate, cortisol, and estrone showed significant longitudinal declines, whereas dihydrotestosterone, pituitary gonadotropins, and PRL rose longitudinally.Apparent good health, defined as absence of chronic illness, prescription medication, obesity, or excessive drinking, added 10 -15% to the level of several androgens and attenuated the cross-sectional trends in T and LH but did not otherwise affect longitudinal or cross-sectional trends.The paradoxical finding that longitudinal age trends were steeper than cross-sectional trends suggests that incident poor health may accelerate the age-related decline in androgen levels. (J Clin Endocrinol Metab 87: 589 -598, 2002)

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“…Por último, la declinación androgénica se acompaña simultáneamente de una caída de estrógenos 3 , la cual está sujeta a las mismas controversias metodológicas del ADAM y cuyo rol biológico es mucho menos claro.…”

Section: Sujetos Y Métodounclassified

Comparación de distintos métodos para evaluar la función androgénica en el adulto mayor

et al. 2006

Rev. méd. Chile

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Aging‐Related Decline of Gonadal Function in Healthy Men: Correlation with Body Composition and Lipoproteins

Cited by 58 publications

References 44 publications

Testosterone: a metabolic hormone in health and disease

Testosterone: a metabolic hormone in health and disease

Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study

Comparación de distintos métodos para evaluar la función androgénica en el adulto mayor

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