Aging-Related Endothelial Progenitor Cell Dysfunction and Its Association with IL-17 and IL-23 in HFmrEF Patients

Zeng, Lingyu; Zhang, Cong; Cai, Guoyi; Zhang, Bin; Huang, Zixia; Wu, Mingyue; Zhu, Yuanting; Luo, Liang; Hao, He; Yang, Zhaohui

doi:10.1155/2022/2281870

Cited by 4 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been shown that AGEs are causative factors for chronic metabolic diseases and skin complications, such as diabetic skin ulcers, susceptibility to infections, and slow or even nonhealing wounds, 8 and are responsible for the frequency of skin problems caused by a high‐sugar diet. Cell behavioral functions such as migration, adhesion, and proliferation decrease with deeper aging, 9 and these changes are shown in Figure 2E. The incidence of skin problems, such as yellowing and browning of skin, poorer elasticity, and deeper wrinkles, increases with the increase in AGEs in the skin 4–6 .…”

Section: Discussionmentioning

confidence: 95%

Unveiling the mechanism of high sugar diet induced advanced glycosylation end products damage skin structure via extracellular matrix–receptor interaction pathway

Li,

Liu,

Shi

et al. 2024

J of Cosmetic Dermatology

View full text Add to dashboard Cite

BackgroundAGEs accumulate in the skin as a result of a high‐sugar diet and play an important role in the skin aging process.ObjectivesThe aim of this study was to characterize the mechanism underlying the effect of a high‐sugar diet on skin aging damage at a holistic level.MethodsWe established a high‐sugar diet mouse model to compare and analyze differences in physiological indexes. The effect of a high‐sugar diet on skin aging damage was analyzed by means of a transcriptome study and staining of pathological sections. Furthermore, the differences in the protein expression of AGEs and ECM components between the HSD and control groups were further verified by immunohistochemistry.ResultsThe skin in the HSD group mice tended toward a red, yellow, dark, and deep color. In addition, the epidermis was irregular with anomalous phenomena, the epidermis was thinned, and the dermis lost its normal structure and showed vacuolated changes. Transcriptomics results revealed significant downregulation of the ECM–receptor interaction pathway, significant upregulation of the expression of AGEs and significant downregulation of the expression levels of COLI, FN1, LM5, and TNC, among others ECM proteins and ECM receptors.ConclusionsHigh‐sugar diets cause skin aging damage by inducing the accumulation of AGEs, disrupting the expression of ECM proteins and their receptors, and downregulating the ECM–receptor interaction pathway, which affects cellular behavioral functions such as cell proliferation, migration, and adhesion, as well as normal skin tissue structure.

show abstract

Section: Discussionmentioning

confidence: 95%

Unveiling the mechanism of high sugar diet induced advanced glycosylation end products damage skin structure via extracellular matrix–receptor interaction pathway

Li,

Liu,

Shi

et al. 2024

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

“…IL‐23, another cytokine that induces Th17 cell differentiation, maintains IL‐17 38 . Zeng et al 39 showed that compared with younger patients, plasma IL‐17 and IL‐23 levels could be increased in older patients with HFmrEF and were closely related to disease severity and circulating endothelial progenitor cell function. Another study demonstrated that the expression of pro‐inflammatory cytokines, and the IL‐23 level were markedly increased in the peripheral blood mononuclear cells of patients with chronic HF, particularly those with severe CHF, suggesting that IL‐23 may play an important role in the progression of CHF 40 .…”

Section: Discussionmentioning

confidence: 99%

Role of serum cytokines in the prediction of heart failure in patients with coronary artery disease

Hou,

Sun,

Zhao

et al. 2023

ESC Heart Failure

View full text Add to dashboard Cite

AimsCoronary artery disease (CAD) is the most common cause of heart failure (HF). This study aimed to identify cytokine biomarkers for predicting HF in patients with CAD.Methods and resultsTwelve patients with CAD without HF (CAD‐non HF), 12 patients with CAD complicated with HF (CAD‐HF), and 12 healthy controls were enrolled for Human Cytokine Antibody Array, which were used as the training dataset. Then, differentially expressed cytokines among the different groups were identified, and crucial characteristic proteins related to CAD‐HF were screened using a combination of the least absolute shrinkage and selection operator, recursive feature elimination, and random forest methods. A support vector machine (SVM) diagnostic model was constructed based on crucial characteristic proteins, followed by receiver operating characteristic curve analysis. Finally, two validation datasets, GSE20681 and GSE59867, were downloaded to verify the diagnostic performance of the SVM model and expression of crucial proteins, as well as enzyme‐linked immunosorbent assay was also used to verify the levels of crucial proteins in blood samples. In total, 12 differentially expressed proteins were overlapped in the three comparison groups, and then four optimal characteristic proteins were identified, including VEGFR2, FLRG, IL‐23, and FGF‐21. After that, the area under the receiver operating characteristic curve of the constructed SVM classification model for the training dataset was 0.944. The accuracy of the SVM classification model was validated using the GSE20681 and GSE59867 datasets, with area under the receiver operating characteristic curve values of 0.773 and 0.745, respectively. The expression trends of the four crucial proteins in the training dataset were consistent with those in the validation dataset and those determined by enzyme‐linked immunosorbent assay.ConclusionsThe combination of VEGFR2, FLRG, IL‐23, and FGF‐21 can be used as a candidate biomarker for the prediction and prevention of HF in patients with CAD.

show abstract

“…Датское общенациональное исследование, в которое был включен 34 371 пациент с легкой формой псориаза и 2621 -с тяжелой, в том числе 607 больных ПсА, показало, что заболеваемость ССЗ и смертность от них возрастает у лиц с псориазом и ПсА, при этом указанные риски сопоставимы с таковыми при сахарном диабете [4]. В рамках российского исследования РЕМАРКА [14] при оценке традиционных факторов сердечно-сосудистого риска (ТФР) у пациентов с ранним ПсА (медиана возраста -36 (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46) лет, медиана длительности заболевания -5 (3-7) месяцев) у 44% была выявлена АГ, у 56% -абдоминальное ожирение, у 64% -факт курения, у 56% -дислипидемия. Сочетание трех и более ТФР ССЗ обнаружено у 48% пациентов.…”

Section: коморбидные состояния при спондилоартритах и их значениеunclassified

Optimal Management of Comorbid Patients with Spondyloarthritis: Focus on Cardiovascular Safety

Karateev¹,

Лучихина²,

Markelova³

2023

EPh

View full text Add to dashboard Cite

Comorbidity and multimobidity are typical for rheumatic diseases (RD) in general. Comorbidities have a complex negative impact on the patient with RD: they are often a direct cause of the premature death of patients, they may contribute to the severe course of the inflammatory process, comorbidities reduce choice of treatment options. Spondyloarthritis, such as psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA), is also characterized by the frequent presence of comorbid conditions, in particular, cardiovascular diseases. Pleiotropic effects of pro-inflammatory cytokines such as interleukin 17A (IL-17A) promote these processes. IL-17A is a versatile pro-inflammatory T cell cytokine. At the same time, there is evidence that IL-17 involved in many other pathological processes: bone tissue remodeling, the development of endothelial dysfunction, formation of the unstable atherosclerotic plaques, heart ventricle remodeling after ischemic attack, etc. Clinical data confirm the role of hyperproduction of IL-17A in the development of cardiovascular diseases. On the example of Secukinumab IL-17A inhibition in PsA and axSpA, it has been shown that this treatment is associated with a high level of cardiovascular safety, and it is likely may help reduce cardiovascular risk. Therapy with IL-17A inhibitors, in particular, Secukinumab, in combination with generally accepted methods of correction of traditional cardiovascular risk factors, may be a promising direction in the management of patients with SpA and concomitant cardiovascular diseases

show abstract

Aging-Related Endothelial Progenitor Cell Dysfunction and Its Association with IL-17 and IL-23 in HFmrEF Patients

Cited by 4 publications

References 43 publications

Unveiling the mechanism of high sugar diet induced advanced glycosylation end products damage skin structure via extracellular matrix–receptor interaction pathway

Unveiling the mechanism of high sugar diet induced advanced glycosylation end products damage skin structure via extracellular matrix–receptor interaction pathway

Role of serum cytokines in the prediction of heart failure in patients with coronary artery disease

Optimal Management of Comorbid Patients with Spondyloarthritis: Focus on Cardiovascular Safety

Contact Info

Product

Resources

About