Aging-Related Findings of the Respiratory System in Chest Imaging: Pearls and Pitfalls

Baratella, Elisa; Fiorese, Ilaria; Minelli, Pierluca; Veiluva, Alberto; Marrocchio, Cristina; Ruaro, Barbara; Cova, Maria Assunta

doi:10.1007/s40134-022-00405-w

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…31 Furthermore, the potential impact of uric acid on lung function can also be attributed to the effects of aging on both the structure and function of the lungs. [32][33][34] With advancing age, natural alterations occur in lung elasticity, muscle strength, and respiratory mechanics, which impact lung capacity and pulmonary function.…”

Section: Discussionmentioning

confidence: 99%

Association between serum uric acid levels and lung function in the NHANES cohort (2007–2012): A cross‐sectional analysis of a diverse American population

Kang,

Xi,

et al. 2024

Int J of Rheum Dis

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BackgroundHyperuricemia has been linked to various health conditions. However, the relationship between uric acid (UA) levels and lung function remains debated.MethodsIn a cross‐sectional study of 6750 participants aged 20–69 from NHANES, we assessed UA levels and lung function (FVC and FEV1). We conducted regression analyses while adjusting for potential confounders.ResultsAfter accounting for factors like age, sex, BMI, smoking, and more, we found a negative association between UA FVC and FEV1. Specifically, for every 0.1 mg/dL increase in UA, FEV1 decreased by 15.265 mL, and FVC decreased by 24.46 mL. No association was observed with FEV1/FVC. Subgroup analyses revealed similar negative correlations among various groups, particularly in non‐Hispanic Black females under 60.ConclusionSerum UA levels are inversely associated with FEV1 and FVC in the American population, with a notable impact on non‐Hispanic Black females under 60.

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Section: Discussionmentioning

confidence: 99%

Association between serum uric acid levels and lung function in the NHANES cohort (2007–2012): A cross‐sectional analysis of a diverse American population

Kang,

Xi,

et al. 2024

Int J of Rheum Dis

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“…These procedures are expensive, invasive and can have significant complication risks. These can be pronounced in the elderly where para-physiological changes occur in the lungs which can lead to inappropriate interpretation of radiological findings that put patients at risk of over or under treatment as Baratella et al report [ 8 ]. Recent work demonstrates that core-needle biopsy performed under CT leads to accurate histological diagnosis of LC with high sensitivity and specificity [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

A novel, accurate, and non-invasive liquid biopsy test to measure cellular immune responses as a tool to diagnose early-stage lung cancer: a clinical trials study

Shai¹,

Patolsky

Drori³

et al. 2023

Respir Res

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Introduction Lung cancer remains the leading cause of death from cancer, worldwide. Developing early detection diagnostic methods, especially non-invasive methods, is a critical component to raising the overall survival rate and prognosis for lung cancer. The purpose of this study is to evaluate two protocols of a novel in vitro cellular immune response test to detect lung cancer. The test specifically quantifies the glycolysis metabolism pathway, which is a biomarker for the activation level of immune cells. It summarizes the results of two clinical trials, where each deploys a different protocol's version of this test for the detection of lung cancer. In the later clinical trial, an improved test protocol is applied. Method The test platform is based on changes in the metabolic pathways of the immune cells following their activation by antigenic stimuli associated with Lung cancer. Peripheral Blood Mononuclear Cells are loaded on a multiwell plate together with various lung tumor associated antigens and a fluorescent probe that exhibits a pH-dependent absorption shift. The acidification process in the extracellular fluid is monitored by a commercial fluorescence plate reader device in continuous reading for 3 h at 37 °C to document the fluorescent signal received from each well. Results In the later clinical trial, an improved test protocol was applied and resulted in increased test accuracy. Specificity of the test increased to 94.0% and test sensitivity increased to 97.3% in lung cancer stage I, by using the improved protocol. Conclusion The improved protocol of the novel cellular immune metabolic response based test detects stage I and stage II of lung cancer with high specificity and sensitivity, with low material costs and fast results.

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“…The main curative treatment of non-small-cell lung cancer (NSCLC) relies on tumor resection [ 1 , 2 , 3 , 4 , 5 ]. Surgery is the preferred treatment for patients with stage I and II NSCLC and for patients with a non-centrally located resectable tumor in the absence of nodal metastasis on both computed tomography (CT) and positron emission tomography (PET) [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Software-Based Assessment of Well-Aerated Lung at CT for Quantification of Predicted Pulmonary Function in Resected NSCLC

Colombi

Risoli

Delfanti

et al. 2023

Life

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Background: To test the agreement between postoperative pulmonary function tests 12 months after surgery (mpo-PFTs) for non-small cell lung cancer (NSCLC) and predicted lung function based on the quantification of well-aerated lung (WAL) at staging CT (sCT). Methods: We included patients with NSCLC who underwent lobectomy or segmentectomy without a history of thoracic radiotherapy or chemotherapy treatment with the availability of PFTs at 12 months follow-up. Postoperative predictive (ppo) lung function was calculated using the resected lobe WAL (the lung volume between −950 and −750 HU) at sCT. The Spearman correlation coefficient (rho) and intraclass correlation coefficient (ICC) were used to the test the agreement between WAL ppo-PFTs and mpo-PFTs. Results: the study included 40 patients (68 years-old, IQR 62–74 years-old; 26/40, 65% males). The WAL ppo-forced expiratory volume in 1 s (FEV1) and the ppo-diffusing capacity of the lung for carbon monoxide (%DLCO) were significantly correlated with corresponding mpo-PFTs (rho = 0.842 and 0.717 respectively; p < 0.001). The agreement with the corresponding mpo-PFTs of WAL ppo-FEV1 was excellent (ICC 0.904), while it was good (ICC 0.770) for WAL ppo-%DLCO. Conclusions: WAL ppo-FEV1 and WAL ppo-%DLCO at sCT showed, respectively, excellent and good agreement with corresponding mpo-PFTs measured 12 months after surgery for NSCLC. WAL is an easy parameter obtained by staging CT that can be used to estimate post-resection lung function for patients with borderline pulmonary function undergoing lung surgery.

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Aging-Related Findings of the Respiratory System in Chest Imaging: Pearls and Pitfalls

Cited by 6 publications

References 38 publications

Association between serum uric acid levels and lung function in the NHANES cohort (2007–2012): A cross‐sectional analysis of a diverse American population

Association between serum uric acid levels and lung function in the NHANES cohort (2007–2012): A cross‐sectional analysis of a diverse American population

A novel, accurate, and non-invasive liquid biopsy test to measure cellular immune responses as a tool to diagnose early-stage lung cancer: a clinical trials study

Software-Based Assessment of Well-Aerated Lung at CT for Quantification of Predicted Pulmonary Function in Resected NSCLC

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