Aging relieves the promotion effects of polyamide microplastics on parental transfer and developmental toxicity of TDCIPP to zebrafish offspring

Photo-oxidation of Micro- and Nanoplastics: Physical, Chemical, and Biological Effects in Environments

“…154 On the other hand, pristine or aged MNPs may serve as a scavenger for OPs, reducing their biouptake. 155 Kim et al suggested that the aged PE MPs reduced the toxicity of BAC 12 but enhanced the toxicity of BAC 16 as the adsorption of BAC 12 was increased but that of relatively hydrophobic BAC 16 was decreased after the aging of MPs. 36 Therefore, the effect of photo-oxidation on the combined toxicity of MNPs and contaminants depends on both the roles of MNPs as carrier or scavenger and the adsorption capacity of pristine/photoaged MNPs.…”

“…However, cases can be complicated for the combined effect of OPs and MNPs after photo-oxidation due to the different role of MNPs (carrier vs scavenger) in the bioaccumulation of OPs, as well as possible increase or decrease in the adsorption capacity of aged MNPs toward OPs. ,, On the one hand, MNPs can facilitate the mobility of OPs, and photo-oxidation enhances or reduces the bioaccumulation of OPs depending on the changed adsorption capacity. , For example, the stress of tilapia caused by PS MPs and propranolol (PRP) was alleviated while those by MPs and sulfamethoxazole (SMX) were exacerbated after photo-oxidation of MPs, as aged MPs adsorbed less PRP but more SMX compared to pristine ones . On the other hand, pristine or aged MNPs may serve as a scavenger for OPs, reducing their biouptake . Kim et al suggested that the aged PE MPs reduced the toxicity of BAC 12 but enhanced the toxicity of BAC 16 as the adsorption of BAC 12 was increased but that of relatively hydrophobic BAC 16 was decreased after the aging of MPs …”

“… 154 On the other hand, pristine or aged MNPs may serve as a scavenger for OPs, reducing their biouptake. 155 Kim et al suggested that the aged PE MPs reduced the toxicity of BAC 12 but enhanced the toxicity of BAC 16 as the adsorption of BAC 12 was increased but that of relatively hydrophobic BAC 16 was decreased after the aging of MPs. 36 …”

Frontier of toxicology studies in zebrafish model

“…Zebrafish is the best and promising high‐throughput vertebrate screening model for assessing environmental toxicants. According to 16 research reports on novel pollutants published in 2022, their developmental toxicity indicators include reduced hatching rates (Gao et al, 2022; Lu, Lv, Kou, et al, 2022; Shi, Qian, et al, 2022; Teng et al, 2022; Wang, Ma, Ding, et al, 2022, Wang, Wang, Wang, et al, 2022; Zhang, Guo, et al, 2022, Zhang, Zhao, et al, 2022), survival rates (Fan, Dai, et al, 2022; Liu, Pan, et al, 2022; Lu, Lv, Kou, et al, 2022), body weight (Lu, Lv, Kou, et al, 2022; Zhang, Zhao, et al, 2022), body length (Chen, Yang, et al, 2022, Chen, Xiao, et al, 2022; Fan, Dai, et al, 2022; Liu, Pan, et al, 2022; Lu, Lv, Kou, et al, 2022; Teng et al, 2022; Wang, Ma, Ding, et al, 2022; Zhang, Zhao, et al, 2022), and heart rate (Chen, Xiao, et al, 2022; Fan, Dai, et al, 2022; Gao et al, 2022; Hua et al, 2022; Teng et al, 2022; Yu, Cheng, et al, 2022; Zhang, Guo, et al, 2022); increased mortality rate (Chen, Xiao, et al, 2022; Wang, Ma, Ding, et al, 2022, Wang, Wang, Wang, et al, 2022; Zhang, Guo, et al, 2022, Zhang, Zhao, et al, 2022) and malformation rate (Chen, Yang, et al, 2022; De Marco et al, 2022; Fan, Dai, et al, 2022; Gao et al, 2022; Liu, Pan, et al, 2022; Lu, Lv, Kou, et al, 2022; Shi, Qian, et al, 2022; Wang, Ma, Ding, et al, 2022; Zhang, Guo, et al, 2022, Zhang, Zhao, et al, 2022); and altered motor behavior (Chen, Xiao, et al, 2022; Fan, Dai, et al, 2022; Gao et al, 2022; Hua et al, 2022; Santos, Barreto, et al, 2022; Teng et al, 2022; Wang, Ma, Ding, et al, 20...…”

“…Lu, Lv, Kou, et al, 2022;Shi, Qian, et al, 2022;Teng et al, 2022;Wang, Ma, Ding, et al, 2022Zhang, Guo, et al, 2022, survival rates(Fan, Dai, et al, 2022;Liu, Pan, et al, 2022;Lu, Lv, Kou, et al, 2022), body weight(Lu, Lv, Kou, et al, 2022;Zhang, Zhao, et al, 2022), body length, Chen, Xiao, et al, 2022Fan, Dai, et al, 2022;Liu, Pan, et al, 2022;Lu, Lv, Kou, et al, 2022;Teng et al, 2022;Wang, Ma, Ding, et al, 2022;Zhang, Zhao, et al, 2022), and heart rate(Chen, Xiao, et al, 2022;Fan, Dai, et al, 2022;Gao et al, 2022;Hua et al, 2022;Teng et al, 2022;Yu, Cheng, et al, 2022;Zhang, Guo, et al, 2022); increased mortality rate(Chen, Xiao, et al, 2022;Wang, Ma, Ding, et al, 2022Zhang, Guo, et al, 2022 and malformation rateDe Marco et al, 2022;Fan, Dai, et al, 2022;Gao et al, 2022;Liu, Pan, et al, 2022;Lu, Lv, Kou, et al, 2022;Shi, Qian, et al, 2022;Wang, Ma, Ding, et al, 2022;Zhang, Guo, et al, 2022; and altered motor behavior(Chen, Xiao, et al, 2022;Fan, Dai, et al, 2022;…”