2021
DOI: 10.1016/j.cmet.2020.11.019
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Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis

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Cited by 60 publications
(38 citation statements)
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“…Taking advantage of the unique capability of SPADE to preserve rare cell types often masked in bulk cellular analysis, we discovered a population of hybrid CD206 and Ly6C co-expressing macrophages which were also significantly increased in critical VML (Figure 4). We found that both of these CD206 hi macrophage subsets have concurrent elevations in CXCR4 expression (Figure S4) which has been reported to be linked to fibrosis, in part through their expression and secretion of tissue inhibitor of metalloprotease 1 (TIMP1) (35). It is notable that CXCR4 is elevated in M2s, as they are known to secrete pro-fibrotic cytokines such as TGF-β.…”
Section: Discussionmentioning
confidence: 80%
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“…Taking advantage of the unique capability of SPADE to preserve rare cell types often masked in bulk cellular analysis, we discovered a population of hybrid CD206 and Ly6C co-expressing macrophages which were also significantly increased in critical VML (Figure 4). We found that both of these CD206 hi macrophage subsets have concurrent elevations in CXCR4 expression (Figure S4) which has been reported to be linked to fibrosis, in part through their expression and secretion of tissue inhibitor of metalloprotease 1 (TIMP1) (35). It is notable that CXCR4 is elevated in M2s, as they are known to secrete pro-fibrotic cytokines such as TGF-β.…”
Section: Discussionmentioning
confidence: 80%
“…The copyright holder for this preprint (which this version posted May 26, 2021. ; https://doi.org/10.1101/2021.05.25.445480 doi: bioRxiv preprint both of these CD206 hi macrophage subsets have concurrent elevations in CXCR4 expression (Figure S4) which has been reported to be linked to fibrosis, in part through their expression and secretion of tissue inhibitor of metalloprotease 1 (TIMP1) (35). It is notable that CXCR4 is elevated in M2s, as they are known to secrete pro-fibrotic cytokines such as TGF-β.…”
Section: Discussionmentioning
confidence: 99%
“…In the future 30 years, the aged group of population would occupy up to one‐fifth of the population 24 . Ageing is one of the strongest inducer in the decline of organ function 25,26 . However, the inducing factors of ageing have not been demonstrated in detail.…”
Section: Discussionmentioning
confidence: 99%
“…24 Ageing is one of the strongest inducer in the decline of organ function. 25 , 26 However, the inducing factors of ageing have not been demonstrated in detail. Among the multiple aetiologies of ageing, mitochondrial dysfunction is thought to be the very important mediator in acceleration of ageing and decline of organ function.…”
Section: Discussionmentioning
confidence: 99%
“…The findings by the Rafii group and the Frenette group demonstrated that the niche microenvironment could be engineered and stimulated to manipulate HSPC maintenance and functions. For example, recent literature has suggested that vascular endothelial cells in the hematopoietic niche maintains HSPC functions during steady state, aging, and injury (Barbier et al, 2020;Chen et al, 2019Chen et al, , 2021Guo et al, 2017;Saçma et al, 2019). Endothelial progenitor cell infusion therapy is an emerging field that may help treat multiple hematologic disorders (Kim et al, 2019;Poulos et al, 2017).…”
mentioning
confidence: 99%