The prevalence of type 2 diabetes mellitus (T2DM) has been developed in the last three decades. Discover an effective solution is necessary to manage and prevent this disease. Physical activity and exercise training is an effective way for metabolic syndrome risk factors in type 2 diabetes mellitus (T2DM) patients. However, there are some uncertainties in effects of Circuit Resistance Training (CRT) program on patients T2DM. The purpose of this study is to investigation the effect of 8 weeks of Circuit resistance training (CRT) on metabolic syndrome and body composition in women over age 50 with T2DM.Twenty women over 50 years old with diabetes Referred to diabetes Center of 17 Shahrivar hospital in Amol and they were divided randomly into two groups; Circuit resistance (n=10) and Control (n=10). Resistance training consisted of 10 stations for 8 weeks and 3 sessions per week (Intensity 60-80% 1RM). Levels of Lipid profile and body composition before and after eight weeks training in both groups were measured. Statistical analysis of the data was carried out by SPSS (v. 22).Fasting Blood Sugar (FBS) levels (P=0.021), Triglycerides (0.010), high-density lipoprotein cholesterol (0.042), significant decreased in CRT. Also after 8 weeks circuit resistance training, BMI (P= 0.003), WHR (P=0.004) and body fat present (0.019) significant decreased in CRT.According to our results, CRT was an effective approach to improve the Anthropometrics, FBS, lipid profile in women over age 50 with diabetes mellitus type 2. Moreover, CRT did have influence on LDL level.