Aging Skin: Nourishing from the Inside Out, Effects of Good Versus Poor Nitrogen Intake on Skin Health and Healing

Corsetti, Giovanni; Pasini, Evasio; Flati, Vincenzo; Romano, Claudia; Rufo, Anna; Dioguardi, Francesco Saverio

doi:10.1007/978-3-642-27814-3_135-1

Cited by 1 publication

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In those animals, a marked alteration of connective tissue and disarrangement of collagen fibers in skin were observed, similar to findings in studies of wound closure [42,43]. The rapid mobilization of amino acids from skin in conditions of nitrogen-qualitative malnutrition is important to consider, since there was a very abundant NEAA intake, with the formulation particularly rich in glutamine and arginine, the so called "conditionally essential amino acids".…”

Section: Regulation Of Protein Syntheses: a Provocative Functional VIsupporting

confidence: 75%

Protein Syntheses and Autophagy: In Contrast or in Synchrony?

Dioguardi¹,

Scarabelli²,

Pasini³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background. Sarcopenia, defined as the loss of skeletal muscle mass and function, is a major clinical problem in many chronic illnesses, in cancer and in the elderly. Exercise and adequate nutrition, peculiarly dependents on availability of essential amino acids, considered the primary strategies for prevention and treatment of protein synthetic deficits, affect both the efficient scavenging of aged and overused protein molecules and the renewal, by maintaining muscular protein synthesis. Many questions still remain about the regulation of protein syntheses and degradation. Degradation of inefficient proteins or organelles is performed by the sum of micro and macro-autophagy plus ubiquitin-proteasome system, activities known as proteostasis, necessary to preserve and promote protein masses and consequently, the body’s reserves. However, how protein synthesis is regulated, and how activation of the mTOR complex may modulate and transduce the flow of information provided by exercise and nutrition to balance proteostasis and syntheses, is far from being fully understood. We suggest that energy production and availability, thus also mitochondria, may have a pivotal role in synchronizing activity and functional outcomes of protein syntheses, and that those syntheses, since higly energy demanding, are main effectors of AMPK dependent autophagy activation by consuming ATP and producing AMP. Conclusion. While in normal conditions protein syntheses drive autophagy activation by decreasing ATP to AMP ratio, conversely autophagy may be inefficiently activated when chronic both low production and consumption of ATP would result in lowest concentrations of AMP, and therefore both blunted rates of protein syntheses and autophagy would be observed. We suggest that this functional hypothesis may explain sarcopenia in many pathological conditions , as in cancer or in aging muscles.

show abstract

Section: Regulation Of Protein Syntheses: a Provocative Functional VIsupporting

confidence: 75%