2020
DOI: 10.1038/s41598-020-64823-6
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Aging with Toxoplasma gondii results in pathogen clearance, resolution of inflammation, and minimal consequences to learning and memory

Abstract: Persistent inflammation has been identified as a contributor to aging-related neurodegenerative disorders such as Alzheimer's disease. Normal aging, in the absence of dementia, also results in gradual cognitive decline and is thought to arise, in part, because of a chronic pro-inflammatory state in the brain. Toxoplasma gondii is an obligate intracellular parasite that establishes a persistent, asymptomatic infection of the central nervous system (CNS) accompanied by a pro-inflammatory immune response in many … Show more

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Cited by 14 publications
(14 citation statements)
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“…4B ). As expected, cyst burden declined over time, but the reduction in mean cyst number was similar between mouse genotypes 24,25 .…”
Section: Resultssupporting
confidence: 74%
“…4B ). As expected, cyst burden declined over time, but the reduction in mean cyst number was similar between mouse genotypes 24,25 .…”
Section: Resultssupporting
confidence: 74%
“…Mean parasite cyst burden was not significantly different between CBA/J mice and Swiss Webster mice at one month post-infection, indicating that a similar number of parasites were accessing the brain niche ( Figure 4 B). As expected, cyst burden declined over time, but the reduction in mean cyst number was similar between mouse genotypes ( McGovern et al., 2020 ; Watson and Davis, 2019 ).
Figure 4 The population structure of the T. gondii chronic infection is dynamic within the murine host brain niche (A) Schematic of an experiment investigating changes in the T. gondii population structure over the course of a three-month in vivo infection in inbred CBA/J and outbred Swiss Webster mice.
…”
Section: Resultssupporting
confidence: 72%
“…Either explanation would preserve circuit function at a global level and potentially allow for relatively quick reversal of these physiologic changes once the inflammatory response subsides. Such possibilities are consistent with the relative lack of behavioral abnormalities seen in Toxoplasma-infected mice who have cleared both the infection and the immune response(McGovern et al, 2020). TINs and bystander physiology suggests that whatever is causing the abnormal TIN's physiology is specific to neurons injected with Toxoplasma protein.…”
supporting
confidence: 56%