Agmatine attenuates intestinal ischemia and reperfusion injury by reducing oxidative stress and inflammatory reaction in rats

TURAN, İnci; Özaçmak, Hale Sayan; Özaçmak, Veysel Haktan; Barut, Figen; Araslı, Mehmet

doi:10.1016/j.lfs.2017.08.032

Cited by 36 publications

(26 citation statements)

References 50 publications

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“…We observed a significant increase in LOOH formation, a byproduct of lipid peroxidation, in the four organs that were studied. Increases in lipid peroxidation have been reported after intestinal IR in such organs as the intestine (Turan et al, 2017), liver (Saidi et al, 2017), and lungs (Barut et al, 2016). Despite these deleterious effects of IR in the ischemic group in the present study, the levels of LOOH in the ileum, lungs, and liver in the IT group that was treated with curcumin remained similar to the control group.…”

Section: Discussionsupporting

confidence: 41%

Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury

Bringhentti

Borges

Neves

et al. 2020

RSD

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We aimed investigate the effects of 45 min of ischemia followed by 72 h of intestinal reperfusion (IR) in the ileum, liver, lungs, and kidneys in Wistar rats and the responses of these organs to curcumin treatment. Ischemia was induced by occluding the superior mesenteric artery. Rats were treated orally with 40 mg/kg curcumin. We analyzed oxidative stress and inflammation in the ileum, liver, lungs, and kidneys. Intestinal IR led to a reduction of reduced glutathione levels in the intestine, lungs, and kidneys and increased lipid hydroperoxide levels in all organs. An increase in the enzymatic activity of catalase was observed in all organs, and an increase in superoxide dismutase activity was observed in the ileum and lungs. Glutathione s-transferase levels increased only in the kidneys. Myeloperoxidase increased in all four organs, and n-acetyl-glycosaminidase increased only in the ileum and lungs. Curcumin prevented all of the changes in the ileum and liver. In the lungs, curcumin had no effect on n-acetyl-glycosaminidase. Curcumin did not prevent the changes in reduced glutathione, lipid hydroperoxides, or myeloperoxidase in the kidneys. Intestinal IR caused oxidative stress and inflammation in the ileum, lungs, and kidneys and to a lesser degree in the liver. Because of its systemic distribution, curcumin prevented changes mainly in the ileum, lungs, and liver and to a lesser degree in the kidneys.

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Section: Discussionsupporting

confidence: 41%

Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury

Bringhentti

Borges

Neves

et al. 2020

RSD

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“…50 In the current study, the GSH level was significantly decreased in ROT-injected rats as compared to the control rats, while administration of agmatine significantly elevated GSH level indicating the antioxidant potential effect of agmatine which was previously reported by many studies. 26,28,38 The effect of agmatine on GSH may involve its direct antioxidant effects of agmatine or the prevention of ROT-induced GSH oxidation.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of agmatine (decarboxylated l-arginine) against oxidative stress and neuroinflammation in rotenone model of Parkinson’s disease

et al. 2018

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Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s disease, characterized by loss of dopaminergic neurons in substantia nigra pars compacta, accompanied by motor and nonmotor symptoms. The neuropathological hallmarks of PD are well reported, but the etiology of the disease is still undefined; several studies assume that oxidative stress, mitochondrial defects, and neuroinflammation play vital roles in the progress of the disease. The current study was established to investigate the neuroprotective effect of agmatine on a rotenone (ROT)-induced experimental model of PD. Adult male Sprague Dawley rats were subcutaneously injected with ROT at a dose of 2 mg/kg body weight for 35 days. Agmatine was injected intraperitoneally at 50 and 100 mg/kg body weight, 1 h prior to ROT administration. ROT-treated rats that received agmatine showed better performance on beam walking and an elevated number of rears within the cylinder test. In addition, agmatine reduced midbrain malondialdehyde as an indication of lipid peroxidation, pro-inflammatory cytokines including tumor necrosis factor alpha and interleukin-1β, and glial fibrillary acidic protein. Moreover, agmatine was responsible for preventing loss of tyrosine hydroxylase-positive neurons. In conclusion, our study showed that agmatine possesses a dose-dependent neuroprotective effect through its antioxidant and anti-inflammatory activities. These findings need further clinical investigations of agmatine as a promising neuroprotective agent for the future treatment of PD.

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“…They may reduce the inflammatory response caused by IIR through Toll-like receptor 4 and nuclear factor-κB p65. 23 Increasing evidences [24][25][26] have proven that the production of reactive oxygen intermediates, which may lead to mucosal cell injury, has massive impact on intestinal ischemia reperfusion injury. A neutrophil proteomics research 27 of intestinal ischemia and reperfusion revealed significantly down regulated transferases and up regulated oxidoreductases.…”

Section: Discussionmentioning

confidence: 99%

Dynamic metabolomic analysis of intestinal ischemia–reperfusion injury in rats

et al. 2020

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Intestinal ischemia–reperfusion injury (IIR) is a life‐threatening abdominal emergency. Compared to traditional steady‐state works, we profiled the blood of rats over 72 hr (15 time points) and examined dynamic changes in molecular pathways during IIR. Using a series of methods designed for dynamic datasets analysis (batch effects corrections, metabolomics data reduction, and different features selection), we identified 39 significant different metabolites and discovered the trends of these molecules. Four main patterns were uncovered by a longitudinal pattern recognition method. Furthermore, pathway networks were explored to uncover the possible mechanisms of IIR. We found that IIR is a complex physiological process involved in multiple pathways, such as biosynthesis of amino acids, 2‐oxocarboxylic acid metabolism, arginine‐related metabolism, and glutathione metabolism. Among which, metabolites related with phenylalanine tyrosine and tryptophan metabolism reached a peak during the early stage of reperfusion, while molecules in biosynthesis of unsaturated fatty acids metabolism declined. Our work provides a feasible scheme to understand dynamic molecule variation and will provide new explications about the effect of intestinal ischemia reperfusion from a dynamic perspective.

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Agmatine attenuates intestinal ischemia and reperfusion injury by reducing oxidative stress and inflammatory reaction in rats

Cited by 36 publications

References 50 publications

Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury

Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury

Neuroprotective effect of agmatine (decarboxylated l-arginine) against oxidative stress and neuroinflammation in rotenone model of Parkinson’s disease

Dynamic metabolomic analysis of intestinal ischemia–reperfusion injury in rats

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