Agmatine enhances the antidepressant-like effect of lithium in mouse forced swimming test through NMDA pathway

Mohseni, Gholmreza; Ostadhadi, Sattar; Imran-Khan, Muhammad; Javidan, Abbas Norouzi; Zolfaghari, Samira; Haddadi, Nazgol‐Sadat; Dehpour, Ahmad Reza

doi:10.1016/j.biopha.2017.01.119

Cited by 27 publications

(8 citation statements)

References 86 publications

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“…Herein, Li administration partly reversed the immobility time and completely reversed decreasing in the sweet food intake. Although some preclinical studies have previously described Li antidepressant effects 41,42 , this is the first study mimicking the maintenance treatment of depressive- and manic-like behaviors in a potential BD animal model. These data suggest that ICV OUA administration in the rat may prove the predictive validity for a BD animal model.…”

Section: Discussionmentioning

confidence: 99%

Validation of the animal model of bipolar disorder induced by Ouabain: face, construct and predictive perspectives

Valvassori¹,

Dal‐Pont²,

Resende³

et al. 2019

Transl Psychiatry

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A particular challenge in the development of a bipolar disorder (BD) model in animals is the complicated clinical course of the condition, characterized by manic, depressive and mixed mood episodes. Ouabain (OUA) is an inhibitor of Na + /K + -ATPase enzyme. Intracerebroventricular (ICV) injection of this drug in rats has been regarded a proper model to study BD by mimic specific manic symptoms, which are reversed by lithium (Li), an important mood stabilizer drug. However, further validation of this experimental approach is required to characterize it as an animal model of BD, including depressive-like behaviors. The present study aimed to assess manic- and depressive-like behaviors, potential alteration in the hypothalamic-pituitary-adrenal (HPA) system and oxidative stress parameters after a single OUA ICV administration in adult male Wistar rats. Moreover, we evaluated Li effects in this experimental setting. Data show that OUA ICV administration could constitute a suitable model for BD since the injection of the drug triggered manic- and depressive-like behaviors in the same animal. Additionally, the OUA model mimics significant physiological and neurochemical alterations detected in BD patients, including an increase in oxidative stress and change in HPA axis. Our findings suggest that decreased Na + /K + -ATPase activity detected in bipolar patients may be linked to increased secretion of glucocorticoid hormones and oxidative damage, leading to the marked behavioral swings. The Li administration mitigated these pathological changes in the rats. The proposed OUA model is regarded as suitable to simulate BD by complying with all validities required to a proper animal model of the psychiatric disorder.

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Section: Discussionmentioning

confidence: 99%

Validation of the animal model of bipolar disorder induced by Ouabain: face, construct and predictive perspectives

Valvassori¹,

Dal‐Pont²,

Resende³

et al. 2019

Transl Psychiatry

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“…Forced swim test is another useful and commonly used assay for the determination of antidepressant like effects of compounds (Mohseni et al, 2017; Sakhaee et al, 2017). Both compounds 1 and 2 showed dose dependent antidepressant effect as given in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.

et al. 2017

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Two new benzyl derivatives were isolated from ethyl acetate fraction of wild strawberry, Fragaria vesca var. nubicola Lindl. ex Hook.f. The structures of these compounds were elucidated to be 5-(4-hydroxy-3-methoxyphenethyl)-7-methoxy-2H-chromen-3-ol (1) and 5-(4-hydroxy-3-methoxyphenethyl)-4,7-dimethoxy-2H-chromen-3-ol (2) based on spectroscopic data through IR, UV, 1H-NMR, 13C-NMR along with two dimensional (2D) techniques HMBC, HMQC, and COSY. Both compounds 1 and 2 were studied in tail suspension and forced swim tests for antidepressant like effects. A significant dose dependent antidepressant like effect was observed by causing spontaneous anti-immobility at various test doses upon intraperitoneal administration.

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“…e forced-swimming test (FST) has been reported to measure the extent of behavioral despair in the CUMS model. e text was conducted according to previously established protocols [29]. e mice swam in a glass beaker filled with water at 24°C for 15 min before testing [30].…”

Section: Forced-swimming Testmentioning

confidence: 99%

Nelumbo nucifera Gaertn Stems (Hegeng) Improved Depression Behavior in CUMS Mice by Regulating NCAM and GAP‐43 Expression

Cao

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Nelumbo nucifera Gaertn stem (Hegeng [HG]) is a traditional Chinese medicine that is used to treat mental symptoms in East Asia. However, scientific evidence is generally lacking to support this traditional claim. Aim of the Study. This study’s aim is to investigate the antidepression effect of HG and to further explore the possible molecular mechanisms that are involved in its actions. Materials and Methods. HG aqueous extract was administered intragastrically for 21 days after the chronic unpredictable mild stress (CUMS) procedure, and its effect on memory, learning, and emotion was assessed using animal behavioral tests. HG aqueous extract was characterized using HPLC. Immunofluorescence was used to measure the neural cell-adhesion molecule (NCAM) and growth-associated protein-43 (GAP-43) expression. Results. Depression-like behaviors increased in the CUMS group compared with the control (CON) group, while they were reduced in the high-dose HG (H-HG) and fluoxetine (FLU) groups (p<0.05). Additionally, NCAM and GAP-43 expression was reduced in the CUMS group compared with the CON group, but it increased in the H-HG and FLU groups (p<0.05). Conclusions. These findings show the potential antidepressant effects of HG through mechanisms involving regulation of NCAM and GAP-43. This provides a new theoretical basis for its potential application as an antidepressant-like agent.

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Agmatine enhances the antidepressant-like effect of lithium in mouse forced swimming test through NMDA pathway

Cited by 27 publications

References 86 publications

Validation of the animal model of bipolar disorder induced by Ouabain: face, construct and predictive perspectives

Validation of the animal model of bipolar disorder induced by Ouabain: face, construct and predictive perspectives

Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.

Nelumbo nucifera Gaertn Stems (Hegeng) Improved Depression Behavior in CUMS Mice by Regulating NCAM and GAP‐43 Expression

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