Agminated blue nevus - Case report

Lisboa, Alice Paixão; Silvestre, Keline Jácome; Pedreira, Renata Leite; Alves, Natália Ribeiro de Magalhães; Obadia, Daniel Lago; Azulay‐Abulafia, Luna

doi:10.1590/abd1806-4841.20164448

Cited by 13 publications

(12 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…a). It might also rarely comprise macular/patchy components, sometimes as small pigmented macules around the naevus (Fig. b).…”

Section: Classical Variants Of Dermal Melanocytosesmentioning

confidence: 99%

“…3 Despite the wide spectrum of their clinical appearances, DMs share common histological and immunophenotypical features with subtle differences. 2 From clinical point of view, these proliferations may be divided into two main categories: blue naevus (BN) presenting mainly with papulonodular lesions (Figs 1-4a) and other DMs presenting predominantly with patchy lesions (Figs 4b,5,6,7,8,9,10; Table 1). The latter DMs have been mainly classified according to the lesion's anatomic location: Mongolian spot (MS; lumbosacral region), naevus of Ota (trigeminal nerve area) and naevus of Ito (acromioclavicular region).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The spectrum of benign dermal dendritic melanocytic proliferations

Baykal

Yılmaz

Sun

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

Dermal melanocytoses (DMs) comprise a heterogeneous group of benign lesions, located on skin and mucous membranes, characterized by dendritic melanocytes in the dermis. Although they share common histopathological features, some variants may present only as bluish or grey patches, some only as papules/nodules/plaques and others may show combination of all of these lesions. Despite the fact that blue naevus (BN) is typically characterized with papulonodular lesions, its variants may show all of the aforementioned presentations. Mongolian spot, naevus of Ota and naevus of Ito are patchy DMs distinguished by their specific localizations. Apart from these classical forms, many atypical variants without unique clinicopathological characteristics have been described in the literature making the nomenclature of DMs more complicated. However, congenital dermal melanocytosis and acquired dermal melanocytosis seem to be crucial umbrella terms that encompass all patchy DMs in atypical locations. Papules or subcutaneous nodules on patchy lesions and association of epidermal pigmentation presenting as brownish patches may be encountered as rare features of DMs. On the other hand, delayed‐onset subcutaneous nodules may be typical presentations of melanoma in patchy DMs; therefore, they deserve special attention. Large plaque‐type BN with subcutaneous cellular nodules is a newly described entity, harbouring clinical features of various DMs together and has a high risk of melanoma. The whole spectrum of dermal dendritic melanocytic proliferations is discussed including novelties and controversial issues.

show abstract

“…a). It might also rarely comprise macular/patchy components, sometimes as small pigmented macules around the naevus (Fig. b).…”

Section: Classical Variants Of Dermal Melanocytosesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The spectrum of benign dermal dendritic melanocytic proliferations

Baykal

Yılmaz

Sun

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…Interestingly, one case highlighted a superficial spreading melanoma (tumor thickness 1.8 mm, pT2aN0M0, stage IB) developing in conjunction with acquired dermal melanocytosis on a nevus spilus . Agminated BN have also been described in conjunction with EMO syndrome/Carney complex (caused by mutations in PRKAR1A ), dermatomyositis, and Darier disease …”

Section: Discussionmentioning

confidence: 99%

“…24 Agminated BN have also been described in conjunction with EMO syndrome/Carney complex (caused by mutations in PRKAR1A), 25 dermatomyositis, 26 and Darier disease. 27 Blue nevi are triggered by constitutive activating mutations in GNAQ or GNA11, the protein products of which signal through the mitogen-activated protein kinases (MAPK) pathway. The most commonly observed mutations are GNAQ p.Q209L and GNA11 p. Q209L, 1,2 representing a mutational hotspot in the genes encoding these proteins.…”

Section: Discussionmentioning

confidence: 99%

Agminated blue nevus with a GNAQ mutation: A case report and review of the literature

et al. 2018

View full text Add to dashboard Cite

Agminated blue nevi are dermal melanocytic proliferations that classically present as dark blue macules or papules in a grouped, linear, or blaschkoid distribution. In their more common sporadic form, blue nevi manifest in young adulthood as solitary blue papules or macules on the scalp, face, hands, or feet. By contrast, agminated blue nevi tend to manifest earlier in life, and are distributed more evenly across anatomic sites. Recent studies have identified mutations in sporadic blue nevi in the genes encoding G Protein subunit alpha Q and G protein subunit alpha 11 (GNAQ and GNA11). It is unknown whether agminated blue nevi share the same genetic changes. In the present paper, we present a case of agminated blue nevus on the wrist, and identify an activating mutation (c.626A > T, p.Glu209Leu) in GNAQ. We hypothesize that GNAQ/GNA11 activating mutations arising earlier during development may trigger agminated blue nevi, explaining the broader field of involvement in these cutaneous lesions.

show abstract

“…Blue nevi are benign melanocytic lesions located in the deeper reticular dermis, usually asymptomatic and solitary. [1] Multiple blue nevi have rarely been reported and are defined as plaque-type, agminated, or eruptive blue nevi. They are generally clustered on a cutaneous surface measuring <10 cm.…”

mentioning

confidence: 99%