Agnogenic myeloid metaplasia preceded by repeated leukemoid reactions and persistent acquired Pelger-Huët anomaly of granulocytes. Case report with review of acquired Pelger-Huët anomaly

Abstract

A case report of agnogenic myeloid metaplasia (AMM) is presented in which a patient had a preliminary 18‐month period characterized by leukemoid reactions to repeated infections alternating with normal health, throughout which an acquired Pelger‐Huët anomaly persisted. This is the only reported case of the anomaly as a premonitory hematologic marker of AMM. The literature concerning the acquired Pelger‐Huët anomaly is reviewed.

Technical Note Cell Dysplasia – Cell Dysplastic Features (A Morphological Note)

“…In contrast, the physiological nuclear segmentation in these or other nucleated blood cells is limited and absent in the PelgerHuet anomaly. Such phenomenon as a ge netically programmed or acquired dysplastic phenome non may be expressed in haematological as well as other clinical disorders (O'Donnell et al, 1982;Liang et al, 2018). In contrast, "chaotic" segmentation reflecting nuclear fragmentation might reflect a regressive pro cess, including the apoptotic one (Ries and Gersch, 1953;Martin and Cotter, 1994).…”

“…The peripheral buds and blebbing on the cell sur face at the onset of the apoptotic process (Fig. 9) might also be considered as dysplastic (Plunkett, 1995;Kerr, 2002;LópezHernández, 2021). However, these known surface phenomena may be related to other cell activi ties such as programmed cell death, cell migration and cancer cell invasion to surrounding tissues (Fackler and Grosse, 2008).…”