Agnogenic myeloid metaplasia

Linman, James W.; Bethell, Frank H.

doi:10.1016/0002-9343(57)90342-x

Cited by 62 publications

(11 citation statements)

References 20 publications

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“…The plasma ESF has been shown to increase after treatment with phenylhydrazine or exposure to reduced atmospheric pressure, and X-irradiation does not prevent the production of increased ESF under such conditions [Stohlman and Brecher, 1954;Linman and Bethell, 1957;Gordon, 1959]. However, difficulties with the assay of ESF have so far made it impossible to demonstrate the opposite changes, a decrease in plasma level after blood transfusion or fasting, although such a decrease has been inferred from the fact that erythropoiesis may be stimulated in transfused or fasted animals by the administration of ESF from an exogenous source [Gurney and Pan, 1958;McCarthy et al, 1959].…”

Section: Discussionmentioning

confidence: 99%

“…For instance after X-irradiation the rate of erythropoiesis may be greatly diminished [Hennessy and Huff, 1950;Bothwell, Hurtado, Donohue and Finch, 1957;Girwin and Hampton, 1959] but the production of ESF appears to be normal (Stohlman and Brecher, 1954;Linman and Bethell, 1957]. Similarly the injection of plasma or plasma extracts rich in ESF enhances erythropoiesis and may produce polycythkemia [Gordon, 1959] and in these circumstances it is unlikely that tissue oxygen supply is reduced.…”

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confidence: 99%

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Factors Regulating Plasma Total Iron Binding Capacity in the Rat and Rabbit

Morgan

1962

Exp Physiol

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Tn order to determine which of the three factors, rate of erythropoiesis, slupply of erythropoietic stimulating factor or tissue oxvaen supply, was involved in the regulation of plasma total iron binding capacity (TIBC) in the rat and rabbit these three factors were varied independentlv of each other. The methods used to do this incluided X-irradiation and starvation and the administration of phenylhydrazine, colchicine, viable erythrocytes and plasma from normal and aneemic rabbits. The changes found in TlBC suggested that the balance between tissue oxygen supply and demand may be the most important factor.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Factors Regulating Plasma Total Iron Binding Capacity in the Rat and Rabbit

Morgan

1962

Exp Physiol

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“…75,176 As a corollary, in studies of idiopathic myelofibrosis, polycythemia vera patients comprised 16% (range, 7%-38%) of the patients and most had been treated with radiation or chemotherapy. 173,175,177,[190][191][192][193] To the extent that it has been evaluated, marrow reticulin was increased in 8% to 15% of polycythemia vera patients at the time of diagnosis, 73,181,194,195 a finding that appeared to have no prognostic significance. 75,150,167 This is in contrast to development of myelofibrosis in CML, which is generally associated with disease acceleration.…”

Section: Myelofibrosismentioning

confidence: 99%

Polycythemia vera: myths, mechanisms, and management

Spivak

2002

Blood

408

331

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“…From previous studies it is obvious that patients with AMM present with strikingly variable clinical (Bouroncle and Doan, 1962;Ward and Block, 1971;Varki et al, 1983;Lewis, 1985;Geary, 1985) as well as histomorphological features (Linman and Bethell, 1957;Pitcock et a/., 1962;Rosenthal and Moloney, 1969;Silverstein, 1975;Lohmann and Beckman, 1983;Frisch et al, 1984;Georgii et al, 1980Georgii et al, , 1984aFrisch and Bartl, 1985;Burkhardt et al, 1984Burkhardt et al, , 1986 at diagnosis. Initially a leukoerythroblastic blood reaction with tear-drop poikilocytosis may be inconspicuous in many patients.…”

Section: Introductionmentioning

confidence: 99%

Agnogenic myeloid metaplasia (AMM)—correlation of bone marrow lesions with laboratory data: A longitudinal clinicopathological study on 114 patients

Thiele¹,

Zankovich²,

Steinberg³

et al. 1989

Hematological Oncology

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A clinicopathological study was performed on 114 patients (46 male/68 female, median age 67 years) with the diagnosis of agnogenic myeloid metaplasia (AMM) respectively primary osteo-myelofibrosis which was not preceded by any other or allied subtype of chronic myeloproliferative disorders. On admission patients revealed a striking variability of laboratory data as well as different histopathological features of initial bone marrow biopsies. For this reason discrimination was done into two groups based on bone marrow findings: group I patients (n = 46, 19 male/27 female) showed a hypercellular marrow without or only borderline (n = 24) to slight (n = 22) reticulin fibrosis and group II cases (n = 68, 27 male/41 female) displayed coarse bundles of collagen fibres (n = 18) frequently accompanied by osteosclerosis (n = 50). Statistical analysis of the corresponding initial hematological findings resulted in significant differences. These differences concerned also the complications occurring during the lengthy course of disease, which included a higher incidence of pancytopenia and severe marrow failure with hemorrhage and blast crisis in group II patients. However, overall survival time was not different in both groups. This may be related to the similarity of age distribution (64 resp. 65 years) and its significant association with arteriosclerotic vascular lesions. Consequently acute myocardial infarction and congestive heart failure were frequent causes of death in addition to infections due to marrow failure and blast crisis. Repeated bone marrow biopsies in 24 patients revealed an insidious transition from hypercellular lesions (group I) into advanced fibro-osteosclerotic changes (group II) concurring with laboratory data. Therefore our discrimination into two groups of patients represents variable stages or static histological and corresponding hematologic features in the evolution of a dynamic disease process in AMM.

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Agnogenic myeloid metaplasia

Cited by 62 publications

References 20 publications

Factors Regulating Plasma Total Iron Binding Capacity in the Rat and Rabbit

Factors Regulating Plasma Total Iron Binding Capacity in the Rat and Rabbit

Polycythemia vera: myths, mechanisms, and management

Agnogenic myeloid metaplasia (AMM)—correlation of bone marrow lesions with laboratory data: A longitudinal clinicopathological study on 114 patients

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