AgNP/Alginate Nanocomposite hydrogel for antimicrobial and antibiofilm applications

Porter, Gemma C.; Schwass, Donald R.; Tompkins, Geoffrey R.; Bobbala, Sharan; Medlicott, Natalie J.; Meledandri, Carla J.

doi:10.1016/j.carbpol.2020.117017

Cited by 77 publications

(41 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(e.g., [35][36][37][38][39][40][41][42][43][44]), and also for the removal of heavy metal salts, e.g., copper, lead, and mercury (e.g., [45][46][47][48][49][50]). The role of alginate in antibacterial finishing of textiles has been reviewed recently by Li et al [51].…”

Section: Introductionmentioning

confidence: 99%

Physical Properties, Chemical Analysis, and Evaluation of Antimicrobial Response of New Polylactide/Alginate/Copper Composite Materials

et al. 2020

View full text Add to dashboard Cite

In recent years, due to an expansion of antibiotic-resistant microorganisms, there has been growing interest in biodegradable and antibacterial polymers that can be used in selected biomedical applications. The present work describes the synthesis of antimicrobial polylactide-copper alginate (PLA–ALG–Cu2+) composite fibers and their characterization. The composites were prepared by immersing PLA fibers in aqueous solution of sodium alginate, followed by ionic cross-linking of alginate chains within the polylactide fibers with Cu(II) ions to yield PLA–ALG–Cu2+ composite fibers. The composites, so prepared, were characterized by scanning electron microscopy (SEM), UV/VIS transmittance and attenuated total reflection Fourier-transform infrared spectroscopy ATR-FTIR, and by determination of their specific surface area (SSA), total/average pore volumes (through application of the 5-point Brunauer–Emmett–Teller method (BET)), and ability to block UV radiation (determination of the ultraviolet protection factor (UPF) of samples). The composites were also subjected to in vitro antimicrobial activity evaluation tests against colonies of Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria and antifungal susceptibility tests against Aspergillus niger and Chaetomium globosum fungal mold species. All the results obtained in this work showed that the obtained composites were promising materials to be used as an antimicrobial wound dressing.

show abstract

Section: Introductionmentioning

confidence: 99%

Physical Properties, Chemical Analysis, and Evaluation of Antimicrobial Response of New Polylactide/Alginate/Copper Composite Materials

et al. 2020

View full text Add to dashboard Cite

show abstract

“…AgNPs range from 1–100 nm in size and have gained popularity for their optical, thermal, and electrical properties [ 46 , 47 ]. With increasing levels of antibiotic resistance, AgNPs have been hypothesized as a solution for improving antibiofilm hydrogels [ 48 ] and current antibiotic treatment options for diseases like tuberculosis ( Table S3 ) [ 49 ]. More specifically, AgNPs have been used to innovate water disinfection, medical diagnostics, pharmaceutical development, anti-cancer therapies, agriculture/livestock treatment, and biofouling control ( Table S3 ) [ 50 , 51 , 52 , 53 , 54 ].…”

Section: Ag Nanoparticlesmentioning

confidence: 99%

Transcriptome Profile Alterations with Carbon Nanotubes, Quantum Dots, and Silver Nanoparticles: A Review

Horstmann

Davenport

Zhang

et al. 2021

Genes

View full text Add to dashboard Cite

Next-generation sequencing (NGS) technology has revolutionized sequence-based research. In recent years, high-throughput sequencing has become the method of choice in studying the toxicity of chemical agents through observing and measuring changes in transcript levels. Engineered nanomaterial (ENM)-toxicity has become a major field of research and has adopted microarray and newer RNA-Seq methods. Recently, nanotechnology has become a promising tool in the diagnosis and treatment of several diseases in humans. However, due to their high stability, they are likely capable of remaining in the body and environment for long periods of time. Their mechanisms of toxicity and long-lasting effects on our health is still poorly understood. This review explores the effects of three ENMs including carbon nanotubes (CNTs), quantum dots (QDs), and Ag nanoparticles (AgNPs) by cross examining publications on transcriptomic changes induced by these nanomaterials.

show abstract

“…Sodium alginate can quickly form a gel under extremely mild conditions, and this gel-forming property is directly related to the G and M content. In the presence of Ca 2+ , Sr 2+ and other cations [23,24], the Na + on the G unit reacts with the cation and the G unit accumulates to form a crosslinked network structure, resulting in the formation of hydrogel. The conditions required for this gel formation and dissociation process are very mild, which effectively avoid the inactivation of sensitive drugs, proteins, cells and enzymes, resulting in excellent biocompatibility and drug loading properties.…”

Section: Sodium Alginate Gelsmentioning

confidence: 99%

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

et al. 2020

View full text Add to dashboard Cite

In recent years, researchers across various fields have shown a keen interest in the exploitation of biocompatible natural polymer materials, especially the development and application of seaweed polysaccharides. Seaweed polysaccharides are a multi-component mixture composed of one or more monosaccharides, which have the functions of being anti-virus, anti-tumor, anti-mutation, anti-radiation and enhancing immunity. These biological activities allow them to be applied in various controllable and sustained anti-inflammatory and anticancer drug delivery systems, such as seaweed polysaccharide-based nanoparticles, microspheres and gels, etc. This review summarizes the advantages of alginic acid, carrageenan and other seaweed polysaccharides, and focuses on their application in gel drug delivery systems (such as nanogels, microgels and hydrogels). In addition, recent literature reports and applications of seaweed polysaccharides are also discussed.

show abstract

AgNP/Alginate Nanocomposite hydrogel for antimicrobial and antibiofilm applications

Cited by 77 publications

References 68 publications

Physical Properties, Chemical Analysis, and Evaluation of Antimicrobial Response of New Polylactide/Alginate/Copper Composite Materials

Physical Properties, Chemical Analysis, and Evaluation of Antimicrobial Response of New Polylactide/Alginate/Copper Composite Materials

Transcriptome Profile Alterations with Carbon Nanotubes, Quantum Dots, and Silver Nanoparticles: A Review

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

Contact Info

Product

Resources

About