Agomelatine improves symptoms of generalised anxiety disorder

Baldwin, David S.; Lopes, Antonio T

doi:10.1136/ebmh.12.2.54

Cited by 4 publications

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References 3 publications

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“…Baldwin met with Bell a few times but could not interview her because he "simply did not know what to say to the mother of a murdered child, still less what to ask. " 62 For fear that "some kind of ghoulish curiosity" might reveal itself in his voice or eyes, he chose instead just to listen to her take on the "official indifference to the slaughter of the children, " which Ms. Bell took to be a reflection of their poverty. 63 Baldwin, feeling "no choice but to suspend judgment" of his "sister, " experiences this shift as a catalyst.…”

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confidence: 99%

The View from the Riverbank

Jones

2023

James Baldwin Review

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This article illustrates the multi-generational influence of Baldwin’s The Evidence of Things Not Seen on my path as a Black scholar and draws connections between representation, identity, kinship, and the interdependence of Black writers in the fight for social justice. Through tracing Baldwin’s working relationship with my father, former editor of Playboy magazine Walter Lowe Jr., I hope to illuminate the relational underpinnings of Baldwin’s work on the Atlanta child murders, thereby foregrounding the complexities of Black life. This article recognizes Baldwin’s work in Evidence as more than just a new-wave logistical, strategic, textual model of resistance but also as a mode of artistic production arising from a tradition that is deeply felt, collaborative, improvisational, and ancestrally rooted.

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confidence: 99%

The View from the Riverbank

Jones

2023

James Baldwin Review

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Lack of Acute Agomelatine Effect in a Model of Social Anxiety in Healthy Volunteers

dos Santos,

da Silva Dias,

Zuardi

et al. 2024

J Clin Psychopharmacol

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Background Agomelatine is an antidepressant drug that acts as an agonist of melatoninergic MT1/2 receptors and an antagonist of serotonergic 5-HT2C receptors. Studies suggest that agomelatine has anxiolytic properties in social anxiety, but there are no studies that assessed the effects of this compound in human experimental anxiety induced by a public speaking test. The objective of our investigation was to assess the effects of agomelatine on human experimental anxiety using the Simulation Public Speaking Test (SPST). Methods Agomelatine (25 mg, n = 14), citalopram (20 mg, n = 14), venlafaxine (75 mg, n = 14), or placebo (n = 14) were administered in single doses to healthy volunteers in a double-blind study. Subjective anxiety was assessed with the Visual Analogue Mood Scale. Arterial blood pressure, heart rate, and blood levels of prolactin and cortisol were also recorded, as well as plasma levels of the 3 drugs. Results The SPST induced significant subjective, physiological, and hormonal effects in all groups. The SPST also increased the anxiety and decreased mental sedation Visual Analogue Mood Scale factors during the anticipatory and performance phases of the test. Citalopram increased anxiety during the test in females, whereas agomelatine and venlafaxine were not different from placebo. Conclusions Confirming previous results, a serotonin selective reuptake inhibitor, citalopram, caused an anxiogenic effect in the SPST only in females. Acute administration of a low dose of agomelatine failed to modify the behavioral and physiological changes caused by this test. Future studies using higher doses and repeated administration should investigate if agomelatine behavioral and physiological effects could be detected in human experimental anxiety models.

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Use of Metabolomics and Proteomics to Reveal Pathophysiological Pathways in Anxiety Disorders

Altmaier¹,

Emeny²

2014

Advances in Biological Psychiatry

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Agomelatine improves symptoms of generalised anxiety disorder

Cited by 4 publications

References 3 publications

The View from the Riverbank

The View from the Riverbank

Lack of Acute Agomelatine Effect in a Model of Social Anxiety in Healthy Volunteers

Use of Metabolomics and Proteomics to Reveal Pathophysiological Pathways in Anxiety Disorders

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