1997
DOI: 10.1111/j.1469-7793.1997.609bj.x
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Agonist action of taurine on glycine receptors in rat supraoptic magnocellular neurones: possible role in osmoregulation

Abstract: To evaluate the implication of taurine in the physiology of supraoptic neurones, we (i) investigated the agonist properties of taurine on glycine and GABAA receptors of supraoptic magnocellular neurones acutely dissociated from adult rats, using whole‐cell voltage clamp, (ii) studied the effects of taurine and strychnine in vivo by extracellular recordings of supraoptic vasopressin neurones in anaesthetized rats, and (iii) measured the osmolarity‐dependent release of endogenous taurine from isolated supraoptic… Show more

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Cited by 203 publications
(177 citation statements)
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“…In particular, any specializations connected with processes, endfeet, or somata cannot be analyzed in cell culture. However, when experiments are conducted in situ, interesting functional interactions are discovered; like the work by Hussy et al (1997) and Sik et al (2000). The elaboration of the role of the VSOAC chan-nel in SON astrocytic-neuronal interactions to sense osmolarity changes and to activate a feedback loop, may lead the way to the discovery of similar functional circuits.…”
Section: Discussionmentioning
confidence: 97%
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“…In particular, any specializations connected with processes, endfeet, or somata cannot be analyzed in cell culture. However, when experiments are conducted in situ, interesting functional interactions are discovered; like the work by Hussy et al (1997) and Sik et al (2000). The elaboration of the role of the VSOAC chan-nel in SON astrocytic-neuronal interactions to sense osmolarity changes and to activate a feedback loop, may lead the way to the discovery of similar functional circuits.…”
Section: Discussionmentioning
confidence: 97%
“…Recent results make a glial-neuronal interaction in this sensory process very likely (Hussy et al, 1997;Deleuze et al, 1998). This mechanism will be in addition to mechanoreceptors in the membrane of SON neurons.…”
Section: Son Osmosensitivitymentioning
confidence: 89%
“…Dissociated neurons were obtained as described previously (Hussy et al, 1997). Young adult male Wistar rats (4 weeks of age) were decapitated without anesthesia, and their brain was rapidly removed and placed in an ice-cold oxygenated modified Locke solution (in mM: 140 NaCl, 2.5 KCl, 10 HEPES, 1.2 KH 2 PO 4 , 10 glucose, 2 CaCl 2 , 2 MgCl 2 , pH 7.4; osmolarity, 300 mOsm/L).…”
Section: Methodsmentioning
confidence: 99%
“…Extracellular recordings of SON OT and VP neurons from anesthetized (urethane intraperitoneally) adult male Wistar rats (250 -400 g) were performed as described previously (Hussy et al, 1997). Rats placed in a stereotaxic apparatus were injected subcutaneously at all points of contention or surgery with 1% xylocaine (Astra Zeneca, Rueil Malmaison, France).…”
Section: Methodsmentioning
confidence: 99%
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