Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding

Wirth, Mary J.; Giraudo, Silvia Q.

doi:10.1016/s0196-9781(00)00280-1

Cited by 72 publications

(52 citation statements)

References 19 publications

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“…The long-lasting hyperphagic response of AgRP is observed in ad libitum fed rats as well as food-restricted rats (Rossi et al, 1998;Wirth and Giraudo, 2000), however, the long-lasting hyperphagic response of SHU9119 (Fan et al, 1997) is absent in food-restricted or food-deprived rats (Williams et al, 2004). This suggests the existence of different mechanisms (e.g.…”

Section: Discussionmentioning

confidence: 97%

AgRP(83–132) and SHU9119 differently affect activity-based anorexia

Hillebrand

Kas

Scheurink

et al. 2006

European Neuropsychopharmacology

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Activity-based anorexia (ABA) mimics starvation and hyperactivity of anorexia nervosa patients in rats. Activation of the melanocortin (MC) system leads to hypophagia and increased energy expenditure in ad libitum fed rats. Therefore, activation of the MC system might underlie the development and propagation of ABA. Pro-opiomelanocortin (POMC) gene expression is normally decreased during negative energy balance. Strikingly, we found a transient up-regulation of POMC mRNA levels in the arcuate nucleus during the development of ABA, indicating a hyperactive MC system. However, wheel running and food intake were not influenced by treating ABA rats with the competitive antagonist SHU9119. This suggests that agonism of MC receptors by endogenous a-melanocyte-stimulating hormone (a-MSH) levels does not underlie ABA. Instead, treatment with the inverse agonist AgRP did ameliorate signs of ABA. This implies that modulation of constitutive MC receptor activity rather than antagonizing putative a-MSH release contributes to the development and propagation of ABA.

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Section: Discussionmentioning

confidence: 97%

AgRP(83–132) and SHU9119 differently affect activity-based anorexia

Hillebrand

Kas

Scheurink

et al. 2006

European Neuropsychopharmacology

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“…AgRP gene expression increases with food deprivation in the arcuate nucleus of laboratory rats and of Siberian hamsters (Hahn et al 1998;Mercer et al 2000) as noted above. In addition, third ventricular, PVH or dorsomedial hypothalamic nucleus injections of AgRP in rats profoundly stimulates food intake, doing so for several days (Hagan et al 2000;Kim et al 2000;Wirth & Giraudo 2000). Previous studies also indicate that the ghrelin-induced increases in food intake in rats are mediated by the melanocortin 3 and 4 receptors (MC-3/4Rs; Kamegai et al 2000Kamegai et al , 2001Nakazato et al 2001).…”

Section: Central Factorsmentioning

confidence: 99%

Physiological mechanisms for food-hoarding motivation in animals

Keen-Rhinehart

Dailey

Bartness

2010

Phil. Trans. R. Soc. B

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The study of ingestive behaviour has an extensive history, starting as early as 1918 when Wallace Craig, an animal behaviourist, coined the terms 'appetitive' and 'consummatory' for the two-part sequence of eating, drinking and sexual behaviours. Since then, most ingestive behaviour research has focused on the neuroendocrine control of food ingestion (consummatory behaviour). The quantity of food eaten, however, is also influenced by the drive both to acquire and to store food (appetitive behaviour). For example, hamster species have a natural proclivity to hoard food and preferentially alter appetitive ingestive behaviours in response to environmental changes and/or metabolic hormones and neuropeptides, whereas other species would instead primarily increase their food intake. Therefore, with the strong appetitive component to their ingestive behaviour that is relatively separate from their consummatory behaviour, they seem an ideal model for elucidating the neuroendocrine mechanisms underlying the control of food hoarding and foraging. This review focuses on the appetitive side of ingestive behaviour, in particular food hoarding, attempting to integrate what is known about the neuroendocrine mechanisms regulating this relatively poorly studied behaviour. An hypothesis is formed stating that the direction of 'energy flux' is a unifying factor for the control of food hoarding.

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“…On the other hand, central administration of AgRP potently increased feeding behavior and body weight in rats (Rossi et al 1998;Wirth and Giraudo 2000), and AgRP acts as a specific competitive antagonist of both MC3R and MC4R (Ollmann et al 1997). It has been reported that MC3R and MC4R are involved in homeostatic regulation of food intake and energy expenditure (Cone 2005).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, AgRP acts as an endogenous antagonist at these receptors (Ollmann et al 1997). AgRP is a potent stimulant of feeding behavior, which functions to control food intake and energy homeostasis in the hypothalamus (Wirth and Giraudo 2000;HaskellLuevano and Monck 2001).…”

Section: Introductionmentioning

confidence: 99%

Expression of pro-opiomelanocortin and agouti-related protein in the hypothalamus of caffeine-administered rats

Jeong

Lee

et al. 2011

Animal Cells and Systems

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In the present study, we examined the effects of caffeine on food intake and body weight, and pro-opiomelanocortin (POMC) and agouti-related protein (AgRP) expression in the hypothalamus. Rats were administered intraperitoneally with 100 mg/kg caffeine (a high, non-toxic dose) or saline during the light phase. Intraperitoneal administration of caffeine induced a significant reduction in food intake and body weight 12 hr after treatment. In addition, POMC expression was significantly increased and AgRP expression was decreased in the arcuate nucleus (Arc) after caffeine treatment. These results demonstrate that administration of caffeine up-regulates POMC expression and down-regulates AgRP expression in the Arc, suggesting that the activation of the hypothalamic POMC neurons and inhibition of the AgRP neurons might play a role in the regulation of food intake and body weight by caffeine.

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Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding

Cited by 72 publications

References 19 publications

AgRP(83–132) and SHU9119 differently affect activity-based anorexia

AgRP(83–132) and SHU9119 differently affect activity-based anorexia

Physiological mechanisms for food-hoarding motivation in animals

Expression of pro-opiomelanocortin and agouti-related protein in the hypothalamus of caffeine-administered rats

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