Agranulocytosis Secondary to Cancer Chemotherapy Associated With Higher In-Hospital Mortality in Patients With Central Line Insertion During a Hospital Stay

Abstract

BackgroundAgranulocytosis secondary to cancer chemotherapy (ASCC) remains a leading cause of morbidity and mortality. Central line-associated bloodstream infections (CLABSI) are also particularly prevalent in these populations and may portend a poorer outcome. Our study serves to investigate the relationship between patients with agranulocytosis secondary to cancer chemotherapy and the insertion of a central venous catheter (CVC) with respect to in-hospital mortality. Methods and resultsWe utilized the National Inpatient Survey 2019 database. We utilized the International Classification of Diseases (ICD)-10 CM codes to identify ASCC and other medical comorbidities. We utilized ICD-10 PCS codes to identify CVC insertions. Multivariate logistic regression was utilized to study the effect of CVC insertion on in-hospital mortality. In patients with ASCC, CVC insertion was associated with a higher inhospital mortality (unadjusted: 11.9% vs. 1%, p<0.001, adjusted OR 19.27, 95% CI 5.84 -65.6, p<0.001) adjusted for baseline characteristics and other comorbidities. Patients in the study cohort who were older than 70 years of age also had a higher in-hospital mortality relative to younger age groups (adjusted OR 2.31, 95% CI 1.04-5.13, p<0.039). ConclusionIn patients with ASCC, CVC insertion during hospitalization is associated with higher in-hospital mortality.

Automated and closed clinical-grade manufacturing protocol produces potent NK cells against neuroblastoma cells and AML blasts

“…Acute myeloid leukemia (AML) stands as the predominant form of acute leukemia in adults marked by significant clinical and genetic heterogeneity. While a subset of patients achieves a cure through a multidisciplinary approach combining chemotherapy, antibody-based treatment, and allogeneic hematopoietic stem cell transplantation (HSCT), the prognosis remains particularly poor for older individuals or those with relapsed or refractory AML (1). Neuroblastoma (NBL), on the other hand, is a challenging solid extracranial tumor in children.…”