Agraphia Caused by Left Thalamic Hemorrhage

Osawa, Aiko; Maeshima, Shinichiro; Yamane, Fumitaka; Uemiya, Nahoko; Ochiai, Ikuo; Yoshihara, Toshio; Ishihara, Shoichiro; Tanahashi, Norio

doi:10.1159/000350713

Cited by 9 publications

(1 citation statement)

References 13 publications

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“…Apraxic agraphia has also been reported following damage to the left thalamus (Ohno et al, 2000). Interestingly, while the structural lesion in this case was focal in the left thalamus, functional imaging showed reduced activity in both the thalamus and the left dorsolateral premotor cortex (see also Osawa et al, 2013), illustrating the complex interactions of a broader network involving both subcortical and cortical regions.…”

Section: Discussionmentioning

confidence: 80%

Voxel-based lesion analysis of brain regions underlying reading and writing

et al. 2018

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The neural basis of reading and writing has been a source of inquiry as well as controversy in the neuroscience literature. Reading has been associated with both left posterior ventral temporal zones (termed the "visual word form area") as well as more dorsal zones, primarily in left parietal cortex. Writing has also been associated with left parietal cortex, as well as left sensorimotor cortex and prefrontal regions. Typically, the neural basis of reading and writing are examined in separate studies and/or rely on single case studies exhibiting specific deficits. Functional neuroimaging studies of reading and writing typically identify a large number of activated regions but do not necessarily identify the core, critical hubs. Last, due to constraints on the functional imaging environment, many previous studies have been limited to measuring the brain activity associated with single-word reading and writing, rather than sentence-level processing. In the current study, the brain correlates of reading and writing at both the single- and sentence-level were studied in a large sample of 111 individuals with a history of chronic stroke using voxel-based lesion symptom mapping (VLSM). VLSM provides a whole-brain, voxel-by-voxel statistical analysis of the role of distinct regions in a particular behavior by comparing performance of individuals with and without a lesion at every voxel. Rather than comparing individual cases or small groups with particular behavioral dissociations in reading and writing, VLSM allowed us to analyze data from a large, well-characterized sample of stroke patients exhibiting a wide range of reading and writing impairments. The VLSM analyses revealed that reading was associated with a critical left inferior temporo-occipital focus, while writing was primarily associated with the left supramarginal gyrus. Separate VLSM analyses of single-word versus sentence-level reading showed that sentence-level reading was uniquely associated with anterior to mid-portions of the middle and superior temporal gyri. Both single-word and sentence-level writing overlapped to a great extent in the left supramarginal gyrus, but sentence-level writing was associated with additional underlying white matter pathways such as the internal capsule. These findings suggest that critical aspects of reading and writing processes diverge, with reading relying critically on the ventral visual recognition stream and writing relying on a dorsal visuo-spatial-motor stream.

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Section: Discussionmentioning

confidence: 80%

Voxel-based lesion analysis of brain regions underlying reading and writing

et al. 2018

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Speech and language adverse effects after thalamotomy and deep brain stimulation in patients with movement disorders: A meta‐analysis

et al. 2017

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Both lesioning and stimulation thalamic surgery produce adverse effects on speech. Left-sided and bilateral procedures are approximately 3-fold more likely to cause speech difficulty. This effect was higher after thalamotomy compared to DBS. In the thalamotomy group, the risk was higher in Parkinson's patients, whereas in the DBS group it was higher in patients with essential tremor. Understanding the pathophysiology of speech disturbance after thalamic procedures is a priority. © 2017 International Parkinson and Movement Disorder Society.

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Aphasia and unilateral spatial neglect due to acute thalamic hemorrhage: clinical correlations and outcomes

Osawa

Maeshima

2016

Neurol Sci

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Thalamic hemorrhages are associated with a variety of cognitive dysfunctions, and it is well known that such cognitive changes constitute a limiting factor of recovery of the activities of daily living (ADL). The relationship between cognitive dysfunction and hematomas is unclear. In this study, we investigated the relationship between aphasia/neglect and hematoma volume, hematoma type, and the ADL. One hundred fifteen patients with thalamic hemorrhage (70 men and 45 women) were studied. Their mean age was 68.9 ± 10.3 years, and patients with both left and right lesions were included. We calculated hematoma volume and examined the presence or absence of aphasia/neglect and the relationships between these dysfunctions and hematoma volume, hematoma type, and the ADL. Fifty-nine patients were found to have aphasia and 35 were found to have neglect. Although there was no relationship between hematoma type and cognitive dysfunction, hematoma volume showed a correlation with the severity of cognitive dysfunction. The ADL score and ratio of patient discharge for patients with aphasia/neglect were lower than those for patients without aphasia/neglect. We observed a correlation between the hematoma volume in thalamic hemorrhage and cognitive dysfunction. Aphasia/neglect is found frequently in patients with acute thalamic hemorrhage and may influence the ADL.

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Agraphia Caused by Left Thalamic Hemorrhage

Cited by 9 publications

References 13 publications

Voxel-based lesion analysis of brain regions underlying reading and writing

Voxel-based lesion analysis of brain regions underlying reading and writing

Speech and language adverse effects after thalamotomy and deep brain stimulation in patients with movement disorders: A meta‐analysis

Aphasia and unilateral spatial neglect due to acute thalamic hemorrhage: clinical correlations and outcomes

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