Agreed Definitions and a Shared Vision for New Standards in Stroke Recovery Research: The Stroke Recovery and Rehabilitation Roundtable Taskforce

Bernhardt, Julie; Hayward, Kathryn S; Kwakkel, Gert; Ward, Nick; Wolf, Steven L.; Borschmann, Karen; Krakauer, John W.; Boyd, Lara A.; Carmichael, S. Thomas; Corbett, Dale; Cramer, Steven C.

doi:10.1177/1545968317732668

Cited by 378 publications

(449 citation statements)

References 52 publications

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“…In opposition to motor learning and compensation, true recovery has been conceptualized as the biological process underlying a change in UE-FM scores from baseline in a thirty days time-window (Bernhardt et al 2017). Here we show that improvements on the UE-FM scale, related to true recovery, can also occur at later stages post-stroke (e.g.…”

Section: Discussionmentioning

confidence: 99%

Revealing an extended critical window of recovery post-stroke

Duff

Maier

et al. 2018

Preprint

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2The impact of rehabilitation on post-stroke motor recovery and its dependency on the patient's 3 chronicity remain unclear. The existence and regularity of a, so called, proportional recovery rule 4 across a range of functional deficits and therapies supports the notion that functional interventions 5 have little or no impact beyond spontaneous recovery rates in a 'critical window of recovery' 6 which lasts from 3 to 6 months post-stroke. In this meta-analysis, we apply a bootstrap analysis 7 method to assess the overall impact of a specific VR-based rehabilitation protocol for the upper 8 extremities on a homogeneous sample of 219 individuals with hemiparesis at various stages 9 post stroke. Our analysis uncovers a precise gradient of sensitivity to treatment that expands 10 more than one year beyond the limits of the so-called 'critical window of recovery'. These findings 11 redefine the limits of the so-called 'critical window of recovery' and suggest that stroke-derived 12 plasticity mechanisms do facilitate functional recovery even at the chronic and late chronic stage. 13

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Section: Discussionmentioning

confidence: 99%

Revealing an extended critical window of recovery post-stroke

Duff

Maier

et al. 2018

Preprint

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“…To be eligible, patients had to have a first stroke (either ischemic or hemorrhagic) less than 6 months before recruitment 30 Candidate patients were evaluated by a physiatrist, and those who satisfied the entry criteria were asked to give their written informed consent. Those who agreed were randomized to one of the treatment programs using a list of codes previously generated through a permuted-block randomization procedure.…”

Section: Participantsmentioning

confidence: 99%

A multimodal training with visual biofeedback in subacute stroke survivors: a randomized controlled trial

Ambrosini

Peri

Nava

et al. 2020

Eur J Phys Rehabil Med

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This provisional PDF corresponds to the article as it appeared upon acceptance.A copyedited and fully formatted version will be made available soon. The final version may contain major or minor changes. Subscription: Information about subscribing to Minerva Medica journals is online at:http://www.minervamedica.it/en/how-to-order-journals.php Reprints and permissions: For information about reprints and permissionssend an email to: journals.dept@minervamedica.it -journals2.dept@minervamedica.it -journals6.dept@minervamedica.it EDIZIONI MINERVA MEDICA ABSTRACT BACKGROUND: Early interventions maximizing patient's involvement are essential to promote gait restoration and motor recovery after stroke. AIM: To evaluate the effects of a multimodal biofeedback training involving cycling augmented by Functional Electrical Stimulation (FES) and balance exercises on walking ability and motor recovery. DESIGN: Randomized controlled trial (NCT02439515). SETTING: Inpatient rehabilitation facility. POPULATION: Subacute stroke survivors (less than 6 months from the first event) with an age of up to 90 years old. METHODS: 68 participants were randomly allocated to an experimental group, performing 15 sessions of biofeedback FES-cycling training followed by 15 sessions of biofeedback balance training (20 minutes each) in addition to usual care (70 minutes), and a control group performing 30 sessions (90 minutes) of usual care. Participants were evaluated before training, after 15 sessions, after 30 sessions, and at 6-month follow-up through: gait speed (primary outcome), spatio-temporal gait parameters, Six Minute Walking Test, Functional Independence Measure, Motricity Index, Trunk Control Test, Berg Balance Scale, and Fall Efficacy Scale. RESULTS: Both groups significantly improved over time, but no group and interaction effects were found for any outcomes. The 73% of the experimental group achieved a clinically meaningful change in gait speed compared to the 38% of the control group (p-value=0.048).These percentages were even more unbalanced for patients with a moderate to severe gait impairment at baseline (91% versus 36%; p-value=0.008). COPYRIGHT© EDIZIONI MINERVA MEDICAThis document is

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“…We therefore tested ODN treatment in a photothrombotic model that produces a small cortical infarction. To further differentiate this second model and comply with stroke basic research recommendation (Bernhardt et al, 2017), we used aged female mice (20 ± 2 months). Finally, to further strengthen the translational relevance of our data, we used a hydrogel impregnated with ODN (0,1 and 5 µg) and performed a single deposition of the hydrogel into the stroke cavity (7.5 µL) 5 days after the onset of stroke ( Figure 5A).…”

Section: Effect Of Odn On Functional Recovery After Photothrombotic Smentioning

confidence: 99%

The gliopeptide ODN, a ligand for the benzodiazepine site of GABA_Areceptors, boosts functional recovery after stroke

Lamtahri

Hazime

Gowing

et al. 2020

Preprint

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Following stroke, the survival of neurons and their ability to re-establish connections is critical to functional recovery. This is strongly influenced by the balance between neuronal excitation and inhibition. In the acute phase of experimental stroke, lethal hyperexcitability can be attenuated by positive allosteric modulation of GABA A receptors (GABA A R). Conversely, in the late phase, negative allosteric modulation of GABA A R can correct the sub-optimal excitability and improves both sensory and motor recovery. Here, we hypothesized that octadecaneuropeptide (ODN), an endogenous allosteric modulator of the GABA A R synthesized by astrocytes, influences the outcome of ischemic brain tissue and subsequent functional recovery. We show that ODN boosts the excitability of cortical neurons, which make it deleterious in the acute phase of stroke. However, if delivered after day 3, ODN is safe and improves motor recovery over the following month in both young and aged mice. Furthermore, we bring evidence that during the sub-acute period after stroke, the repairing cortex can be treated with ODN by means of a single hydrogel deposit into the stroke cavity.

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Agreed Definitions and a Shared Vision for New Standards in Stroke Recovery Research: The Stroke Recovery and Rehabilitation Roundtable Taskforce

Cited by 378 publications

References 52 publications

Revealing an extended critical window of recovery post-stroke

Revealing an extended critical window of recovery post-stroke

A multimodal training with visual biofeedback in subacute stroke survivors: a randomized controlled trial

The gliopeptide ODN, a ligand for the benzodiazepine site of GABA_Areceptors, boosts functional recovery after stroke

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Agreed Definitions and a Shared Vision for New Standards in Stroke Recovery Research: The Stroke Recovery and Rehabilitation Roundtable Taskforce

Cited by 378 publications

References 52 publications

Revealing an extended critical window of recovery post-stroke

Revealing an extended critical window of recovery post-stroke

A multimodal training with visual biofeedback in subacute stroke survivors: a randomized controlled trial

The gliopeptide ODN, a ligand for the benzodiazepine site of GABAAreceptors, boosts functional recovery after stroke

Contact Info

Product

Resources

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The gliopeptide ODN, a ligand for the benzodiazepine site of GABA_Areceptors, boosts functional recovery after stroke