Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16‐positive women: a clinical trial using dynamic spectral imaging colposcopy

Zaal, Afra; Louwers, J.A.; Berkhof, Johannes; Kocken, M.; Harmsel, W.A. ter; Graziosi, G.C.M.; Spruijt, J.W.M.; Balas, Costas; Papagiannakis, Emmanouil; Snijders, Peter J.F.; Meijer, Chris J.L.M.; Kemenade, Folkert J. van; Verheijen, René H.M.

doi:10.1111/j.1471-0528.2012.03280.x

Cited by 48 publications

(42 citation statements)

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“…However, the sensitivity of dynamic spectral imaging colposcopy for CIN2+ was higher in HPV16-positive than in non-16 hrHPV-positive women which may be explained by the better identification of small CIN2 lesions with this technique. 22 This is in agreement with our finding that in this population of women with abnormal cervical screening results, the visual colposcopic appearance of HPV16-positive women does not differ from that in women infected with other HPV types. Studies have shown that HPV16 is the genotype with the highest oncogenic potential because it is associated with the highest risk of the development of CIN3 and cancer and has the highest worldwide attribution for CIN2+ and ICC.…”

Section: Discussionsupporting

confidence: 92%

“…Our theory is in line with the findings of Wentzensen et al, 31 who observed a difference in lesion size between women with HPV16 and other types in CIN2, but not in CIN3. Zaal et al 22 found that with conventional visual colposcopy, no difference in sensitivity for CIN2+ lesions caused by different HPV types was found. However, the sensitivity of dynamic spectral imaging colposcopy for CIN2+ was higher in HPV16-positive than in non-16 hrHPV-positive women which may be explained by the better identification of small CIN2 lesions with this technique.…”

Section: Discussionmentioning

confidence: 99%

“…20,21 HPV genotype 16 is suggested to cause more definite visual abnormalities than other HPV types. 5,22 Women with CIN2+ frequently present with multiple HPV genotypes in cytology. 23 In a study using laser capture microdissection (LCM) in women positive for multiple HPV types in cytology we have shown that HPV16 is the most predominant causal genotype in CIN2+ lesions.…”

Section: Introductionmentioning

confidence: 99%

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The impact of human papillomavirus genotype on colposcopic appearance: a cross‐sectional analysis

Marel

Baars

Quint

et al. 2014

BJOG

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Objective To study colposcopic performance in diagnosing high-grade cervical intraepithelial neoplasia or cervical cancer (CIN2+ and CIN3+) using colposcopic characteristics and high-risk human papillomavirus (hrHPV) genotyping.Design Cross-sectional multicentre study.Setting Two colposcopy clinics in The Netherlands and Spain.Population Six hundred and ten women aged 17 years and older referred for colposcopy because of abnormal cytology.Methods A cervical smear was obtained. Colposcopists identified the worst lesion, graded their impression and scored the colposcopic characteristics of the lesions. Up to four biopsies were collected, including one biopsy from visually normal tissue.Main outcome measures CIN2+ and CIN3+, positive for HPV16 or other high-risk HPV types (non-16 hrHPV-positive).Results The mean age in HPV16-positive CIN2+ women was 35.1 years compared with 39.1 years in women with other hrHPV types (P = 0.002). Sensitivity for colposcopy to detect CIN2+ was 87.9% (95%CI 83.2-91.5), using colposcopic cut-off of 'any abnormality'. The remaining CIN2+ were found by a biopsy from visually normal tissue or endocervical curettage (ECC Conclusions In this population following European screening practice, HPV16-related CIN2+ lesions were detected at younger age and showed similar colposcopic impression as non-16 hrHPV high-grade lesions. There was no relationship between any of the colposcopic characteristics and HPV16 status.Keywords Cervical intraepithelial neoplasia, colposcopy, genotyping, HPV16, human papillomavirus.Please cite this paper as: van der Marel J, van Baars R, Quint WGV, Berkhof J, del Pino M, Torn e A, Ordi J, Wentzensen N, Schiffman M, van de Sandt MM, Lindeman J, Jenkins D, Helmerhorst TJM, Verheijen RHM, ter Harmsel B, Alonso I. The impact of human papillomavirus genotype on colposcopic appearance: a cross-sectional analysis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The impact of human papillomavirus genotype on colposcopic appearance: a cross‐sectional analysis

Marel

Baars

Quint

et al. 2014

BJOG

Self Cite

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“…Although this was not the aim of the study and these results are not reliable enough, the sensitivity of DySIS was similar to that found in previously published clinical trials [14,15,16]. …”

Section: Discussionmentioning

confidence: 50%

“…It is a digital colposcope that can be used to perform CC and also measures the dynamic color changes associated with cervical lesions after the application of acetic acid. During the examination, the software that is embedded in the device calculates and displays a color-coded map that represents not only the localization, but also reflects the severity of the cervical lesion, indicating the best areas for biopsies [15,16]. It has been demonstrated that when the DySIS map is integrated in the colposcopic examination, the colposcopic sensitivity to detect high-grade disease increases significantly [15].…”

Section: Introductionmentioning

confidence: 99%

Correlating the Accuracy of Colposcopy with Practitioner Experience when Diagnosing Cervical Pathology Using the Dynamic Spectral Imaging System

Coronado

Fasero

2014

Gynecol Obstet Invest

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Background/Aims: To assess the performance of colposcopists and correlate it with their experience when diagnosing cervical pathology by reviewing conventional colposcopy (CC) digital images and the Dynamic Spectral Imaging System (DySIS) cervical map. Methods: Images from 50 women with normal and abnormal cervix collected during CC and the corresponding DySIS maps were projected consecutively to 63 participating colposcopists. Participants were asked for their diagnosis (normal, abnormal findings or cancer). The clinical experience of the participants was divided into low (n = 27), medium (n = 18) and high (n = 18), considering the number of colposcopies each one performed routinely. Results: The mean of overall correct diagnoses was significantly higher with DySIS than CC for the low and medium experience group (20.4 vs. 24.4, and 21.9 vs. 26.0, respectively; p < 0.001), but not in the high experience group. The correct diagnosis was significantly higher with DySIS than CC for all experience groups in cases with a normal cervix and cervical intraepithelial neoplasia 2+ (CIN2+), but not for those with CIN1. All groups agreed that DySIS guides biopsies better, offers more information and allows performing colposcopy even without extensive experience. Conclusions: The results of evaluating projected colposcopy images were more successful with DySIS than with CC in the diagnosis of cervical pathology, especially among less experienced colposcopists.

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A systematic review of handheld tools in lieu of colposcopy for cervical neoplasia and female genital schistosomiasis

Søfteland

Sebitloane

Taylor

et al. 2021

Intl J Gynecology & Obste

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Background Visualization of the lesions in the lower genital tract is the mainstay for diagnosis of the four lesions found in female genital schistosomiasis (FGS), but colposcopes are generally not available in low‐resource settings. Objective We sought to review handheld devices that could potentially be used for FGS diagnosis. Search strategy We searched Medline and Embase 2015–2019 for handheld devices used in cervical cancer screening and FGS diagnosis. Selection criteria We excluded studies that did not compare the device to standard‐of‐care colposcopes or histopathology. Main results and conclusion In 11 studies, four handheld colposcopes, two smartphones, and one compact digital camera were evaluated. Two handheld colposcopes were found to be potentially adequate for FGS diagnosis, namely Gynocular and Mobile ODT. The smartphones and digital camera did not have sufficient magnification to diagnose grainy sandy patches, one of the FGS lesion types. Customized software should be made to support the diagnosis of both FGS and cervical neoplasia. Real‐time postgraduate training and quality control should be considered in future studies of handheld colposcopes. For patients from schistosomiasis endemic areas, we recommend that handheld devices are used for FGS. Studies are needed to determine which of the two devices is most adequate for FGS diagnosis in schistosomiasis endemic areas.

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Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16‐positive women: a clinical trial using dynamic spectral imaging colposcopy

Cited by 48 publications

References 22 publications

The impact of human papillomavirus genotype on colposcopic appearance: a cross‐sectional analysis

The impact of human papillomavirus genotype on colposcopic appearance: a cross‐sectional analysis

Correlating the Accuracy of Colposcopy with Practitioner Experience when Diagnosing Cervical Pathology Using the Dynamic Spectral Imaging System

A systematic review of handheld tools in lieu of colposcopy for cervical neoplasia and female genital schistosomiasis

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