2010
DOI: 10.1038/jp.2010.132
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Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy

Abstract: Objective We undertook this study to assess the agreement between fetal umbilical cord drug levels and maternal self-report. Study Design Cord samples were collected from 103 placentas after delivery as a sub-project of the larger Pacific Research Center for Early Human Development (PRCEHD) study. These cord samples were then processed to obtain cord lysates and enzyme-linked immunosorbent assay (ELISA) performed for cotinine and illicit drugs. Levels of each of these substances were compared with clinical i… Show more

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Cited by 22 publications
(18 citation statements)
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“…Although we question the accuracy of reviewing 'nursing flow sheets y to determine the proportion of total intake that was comprised of MBM (maternal breast milk)' unless infants received measured volumes of expressed breast milk rather than suckling, the observed association between maternal breast milk feedings and shorter duration of neonatal methadone treatment complements our own observations and supports encouragement of breastfeeding in this population. Contrary to Isemann et al, 1 we did not observe any cases of rebound withdrawal symptoms amongst the 51 infants in our group who were still breastfeeding at discharge, but we agree wholeheartedly that further studies in this area are warranted. We described almost three times as many preterm infants (90 versus 36) and observed no association between preterm birth and the development of NAS.…”
contrasting
confidence: 55%
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“…Although we question the accuracy of reviewing 'nursing flow sheets y to determine the proportion of total intake that was comprised of MBM (maternal breast milk)' unless infants received measured volumes of expressed breast milk rather than suckling, the observed association between maternal breast milk feedings and shorter duration of neonatal methadone treatment complements our own observations and supports encouragement of breastfeeding in this population. Contrary to Isemann et al, 1 we did not observe any cases of rebound withdrawal symptoms amongst the 51 infants in our group who were still breastfeeding at discharge, but we agree wholeheartedly that further studies in this area are warranted. We described almost three times as many preterm infants (90 versus 36) and observed no association between preterm birth and the development of NAS.…”
contrasting
confidence: 55%
“…Strength in numbers: a step closer to standardising perinatal care for drug-misusing women and their infants We read with great interest the recent paper by Isemann et al 1 In this retrospective review of 128 neonates the severity of neonatal abstinence syndrome (NAS) was mitigated by reducing maternal methadone dose during pregnancy and encouraging breastfeeding. We fully support these conclusions but believe there to be some shortcomings in the study including failure to document the incidence of NAS in the population studied.…”
mentioning
confidence: 93%
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“…
We read with interest the paper by Wright TE et al 1 and we would like to add some conclusions reached by our group after a clinical research evaluating prenatal exposure to tobacco smoke by cotinine in cord blood. 2 Prenatal tobacco exposure has been usually assessed using selfreported maternal questionnaire.
…”
mentioning
confidence: 89%
“…Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy We thank Garcia-Algar et al 1 for their interest in our recent work. We agree with their conclusions that cord serum is a reliable indicator of smoke exposure, both direct and environmental.…”
mentioning
confidence: 99%