Agricultural pesticide exposure and chronic kidney disease: new findings and more questions

Calvert, Geoffrey M.

doi:10.1136/oemed-2015-103132

Cited by 14 publications

(10 citation statements)

References 10 publications

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“…The present study indicates nephrotoxicity of deltamethrin. The increased serum creatinine and urea levels in deltamethrin-exposed mice agrees with the results of prior studies reporting nephrotoxic changes in workers occupationally exposed to pesticides (El-Gerbed, 2014; Calvert, 2016; Valcke et al, 2017). Treatment of mice with carbofuran and lambda-cyhalothrin has caused elevated blood urea nitrogen and creatinine levels, indicating toxicity to the renal system (Fetoui et al, 2010; Mostafa et al, 1992).…”

Section: Discussionsupporting

confidence: 90%

Sublethal chronic effects of oral dietary exposure to deltamethrin in Swiss albino mice

2018

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The hazards of dietary exposure to environmentally relevant levels of deltamethrin are poorly understood though studies enunciate the acute toxicity hazards. In this study, prolonged exposure to low levels of deltamethrin in mice was investigated. The mice were exposed daily via gavage method for 60 days. Four doses (0.1, 0.05, 0.01, and 0.005 mg/kg bwt/d) were selected, which are equal to or less than the maximum residue limits for deltamethrin permitted in animal food/feed. Liver, kidney, lungs, spleen, and testes were collected on day 61 for histology, residue, and biochemical analysis (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALKP), total bilirubin (TBIL), total proteins (TPs), cholesterol (CHOL), urea, and creatinine). No significant changes were observed in body weight gain in all treatment groups ( p > 0.05). The gas chromatography analysis indicated that none of the tissue samples contained deltamethrin residues above the limits of quantification. The significant differences in biochemical profile (AST, ALT, TBIL, and creatinine) reported in animals exposed to 0.1 and 0.05 mg/kg bwt/d deltamethrin ( p < 0.05) suggest respective tissue injury and lipid peroxidation; however, few significant changes in urea and CHOL were also reported in doses 0.01 and 0.005 mg/kg bwt. No significant differences in TP and ALKP were observed ( p > 0.05). The target organs for deltamethrin toxicity showed prominent histopathological changes in concentrations of 0.1 and 0.05 mg/kg bwt. Other two doses showed no or sporadic changes. Our findings suggest that chronic exposure to environmentally relevant levels of deltamethrin can have detrimental effects on vital organs in the circumstances allowing daily exposure, in congruence with available literature.

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Section: Discussionsupporting

confidence: 90%

Sublethal chronic effects of oral dietary exposure to deltamethrin in Swiss albino mice

2018

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“…However, as our results illustrate, there appears to be differences between domains within each of these two categories or at least fluid cognitive abilities. The match between job tasks and which cognitive measures to include in studies, may be of importance [ 28 ]. Following the use it or lose it hypothesis, different job types are likely to maintain different cognitive domains depending on which cognitive skills are needed to perform the job.…”

Section: Discussionmentioning

confidence: 99%

The impact of retirement on age related cognitive decline – a systematic review

2017

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BackgroundKnowledge on factors affecting the rate of cognitive decline and how to maintain cognitive functioning in old age becomes increasingly relevant. The purpose of the current study was to systematically review the evidence for the impact of retirement on cognitive functioning and on age related cognitive decline.MethodWe conducted a systematic literature review, following the principles of the PRISMA statement, of longitudinal studies on the association between retirement and cognition.ResultsOnly seven studies fulfilled the inclusion criteria. We found weak evidence that retirement accelerates the rate of cognitive decline in crystallised abilities, but only for individuals retiring from jobs high in complexity with people. The evidence of the impact of retirement on the rate of decline in fluid cognitive abilities is conflicting.ConclusionThe review revealed a major knowledge gap in regards to the impact of retirement on cognitive decline. More knowledge on the association between retirement and age related cognitive decline as well as knowledge on the mechanisms behind these associations is needed.Electronic supplementary materialThe online version of this article (doi:10.1186/s12877-017-0556-7) contains supplementary material, which is available to authorized users.

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“…Many studies on Western and Asian countries have shown that involving in physically active jobs is inversely associated with the risk of breast cancer, while sedentary or office work has a positive association [ 10 , 15 – 19 ]. However, a pooled analysis of two case-control studies in Australia and Canada reported no association between occupational activity level and the risk of developing breast cancer [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Association of job category and occupational activity with breast cancer incidence in Japanese female workers: the JACC study

et al. 2020

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Background Breast cancer represented the leading cause of cancer deaths among women in Japan. Although physical activity has been reported protective against breast cancer, scientific evidence is limited on the risk of breast cancer according to job category or occupational activity in Japanese. Our objective was to examine the association of job category and occupational activity with breast cancer incidence in Japanese female workers using the data from the Japan Collaborative Cohort (JACC) Study. Methods A prospective cohort study involving 19,041 women aged 40–79 years who have reported their occupational data and followed-up from 1988 to 2009. All variables were assessed by a self-administered questionnaire. Cancer incidence data were obtained from 24 areas of the JACC study through cancer population data registration, or review of hospital records. The Cox proportional hazard models were operated to calculate the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Results There were 138 incident cases of breast cancer during 13.3 years median follow-up period. Office workers compared with manual workers were at a higher risk of breast cancer after adjusting for reproductive health factors and physical activity indicators; the multivariable HR (95% CI) was 1.65 (1.07–2.55). Also, women who had mainly a sitting position during work compared with those moving during work had the higher risk: the multivariable HR (95%CI) of 1.45 (1.01–2.12). The excess risk of breast cancer was observed for office workers when time spent in walking was < 30 min/ day; HR (95% CI) was 1.11 (1.01–1.23), and for women mainly at a sitting position during work when time spent in walking was 30–59 min or < 30 min/day; HRs (95% CIs) were 1.87 (1.07–3.27) and 1.74 (1.07–2.83), respectively. Conclusion The job category and occupational activity were associated with risk of breast cancer incidence. A high risk was observed in office workers and in women with a sitting position during work. These observed increased risks were evident in women with less daily walking activity.

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Agricultural pesticide exposure and chronic kidney disease: new findings and more questions

Cited by 14 publications

References 10 publications

Sublethal chronic effects of oral dietary exposure to deltamethrin in Swiss albino mice

Sublethal chronic effects of oral dietary exposure to deltamethrin in Swiss albino mice

The impact of retirement on age related cognitive decline – a systematic review

Association of job category and occupational activity with breast cancer incidence in Japanese female workers: the JACC study

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