Pharmaceuticals and Personal Care
Products (PPCPs) are
synthetic
compounds widely used as consumer items such as cosmetics and therapeutic
drugs across the globe. The inappropriate disposal of PPCPs in the
environment has raised serious concerns regarding their potential
adverse impacts on human and animal health. Hence, the present study
aims to delve into the environmental contamination of numerous PPCPs
and their detrimental impacts on biota and climate change. Mining
of data published in the relevant literature has revealed that active
ingredients of PPCPs and their metabolites generally invade the ecosystem
via multiple sources. Varying concentrations of these contaminants
are reported in surface water, groundwater, and wastewater treatment
plants. The majority of PPCPs pose acute and chronic toxicity to living
organisms. They adversely affect the structure and function of the
algal community along with the feeding, mating, metabolic activities,
and reproductive behavior of invertebrates, fishes, and higher vertebrates,
including humans. The occurrence of antibiotic resistance in bacterial
populations as a response to PPCP contamination is another health
concern. In addition, targeting mitochondrial respiratory proteins
and cytochrome enzymes by PPCPs might contribute to the onset of multiple
physiological ailments. Studies have deciphered the connection between
PPCP contamination and methanogenesis, which could potentially impact
climate change. Several degradation methods have been used for the
removal of PPCPs. However, none of them completely remove the PPCPs
from samples. Therefore, developing more advanced eco-friendly approaches
is warranted for better treatment of PPCPs in water media. In addition,
further investigations are required for the risk assessment of several
PPCPs that have not yet been investigated.