Agricultural production: assessment of the potential use of Cas9-mediated gene drive systems for agricultural pest control

Scott, Maxwell J.; Gould, Fred; Lorenzen, Marcé D.; Grubbs, Nathaniel; Edwards, Owain; O’Brochta, David A.

doi:10.1080/23299460.2017.1410343

Cited by 76 publications

(54 citation statements)

References 97 publications

(126 reference statements)

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“…Molecular technologies present novel solutions to previously intractable problems in resistance management and some of these have application to Australian grain pests. For example, CRISPR technology could be deployed to modify the genome of pests and, using a natural or synthetic gene drive mechanism, drive susceptible alleles back into resistant populations. Helicoverpa armigera would be a strong candidate because many simple resistance mutations to Bt toxins have already been identified, and this approach could be integrated into an existing resistance management program .…”

Section: The Future Of Resistance Management In Australian Grainsmentioning

confidence: 99%

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Escalating insecticide resistance in Australian grain pests: contributing factors, industry trends and management opportunities

Umina

McDonald

Maino

et al. 2019

Pest Management Science

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Insecticide resistance is an ever‐increasing problem that threatens food production globally. Within Australia, the grain industry has a renewed focus on resistance due to diminishing chemical options available to farmers and the increasing prevalence and severity of resistance encountered in the field. Chemicals are too often used as the major tool for arthropod pest management, ignoring the potent evolutionary forces from chemical selection pressures that lead to resistance. A complex array of factors (biological, social, economic, political, climatic) have contributed to current trends in insecticide usage and resistance in the Australian grain industry. We review the status of insecticide resistance and provide a context for how resistance is currently managed. We discuss emerging technologies and research that could be applied to improve resistance management. This includes generating baseline sensitivity data for insecticides before they are launched, developing genetic diagnostics for the full complement of known resistances, expanding resistance monitoring programs, and utilizing new technologies. Additional benefits are likely to be achieved through a combination of industry awareness and engagement, risk modeling, adoption of integrated pest management tactics, greater collaboration between industry stakeholders, and policy changes around chemical use and record keeping. The Australian grain context provides lessons for other agricultural industries. © 2018 Society of Chemical Industry

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Section: The Future Of Resistance Management In Australian Grainsmentioning

confidence: 99%

“…A more contained method to drive down resistance alleles is the sterile insect technique (SIT) . Recent modeling indicates the mass release of a male selecting strain of P. xylostella carrying insecticide susceptible alleles can effectively drive susceptibility into target populations .…”

Section: The Future Of Resistance Management In Australian Grainsmentioning

confidence: 99%

Escalating insecticide resistance in Australian grain pests: contributing factors, industry trends and management opportunities

Umina

McDonald

Maino

et al. 2019

Pest Management Science

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“…Strategies to use gene drives in the context of GM insects can be differentiated based on (e.g. Eckhoff et al., ; James et al., ; Scott et al., ): desired outcome: population suppression vs. population replacement, ability of the trait to establish or spread: self‐sustaining vs. self‐limiting drives. …”

Section: Problem Formulation In Practice: Case Studiesmentioning

confidence: 99%

Using problem formulation for fit‐for‐purpose pre‐market environmental risk assessments of regulated stressors

Devos

Devlin

Ippolito

et al. 2019

EFS2

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Pre-market/prospective environmental risk assessments (ERAs) contribute to risk analyses performed to facilitate decisions about the market introduction of regulated stressors. Robust ERAs begin with an explicit problem formulation, which involves among other steps: (1) formally devising plausible pathways to harm that describe how the deployment of a regulated stressor could be harmful; (2) formulating risk hypotheses about the likelihood and severity of such events; (3) identifying the information that will be useful to test the risk hypotheses; and (4) developing a plan to acquire new data for hypothesis testing should tests with existing information be insufficient for decision-making. Here, we apply problem formulation to the assessment of possible adverse effects of RNA interference-based insecticidal genetically modified (GM) plants, GM growth hormone coho salmon, gene drive-modified mosquitoes and classical biological weed control agents on non-target organisms in a prospective manner, and of neonicotinoid insecticides on bees in a retrospective manner. In addition, specific considerations for the problem formulation for the ERA of nanomaterials and for landscape-scale population-level ERAs are given. We argue that applying problem formulation to ERA maximises the usefulness of ERA studies for decision-making, through an iterative process, because: (1) harm is defined explicitly from the start; (2) the construction of risk hypotheses is guided by policy rather than an exhaustive attempt to address any possible differences; (3) existing information is used effectively; (4) new data are collected with a clear purpose; (5) risk is characterised against well-defined criteria of hypothesis corroboration or falsification; and (6) risk assessment conclusions can be communicated clearly. However, problem formulation is still often hindered by the absence of clear policy goals and decision-making criteria (e.g. definition of protection goals and what constitutes harm) that are needed to guide the interpretation of scientific information. We therefore advocate further dialogue between risk assessors and risk managers to clarify how ERAs can address policy goals and decision-making criteria. Ideally, this dialogue should take place for all classes of regulated stressors, as this can promote alignment and consistency on the desired level of protection and maximum tolerable impacts across regulated stressors.

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“…Throughout, the authors helpfully reference historical case studies of GM crops, releases of sterile insects, and classical biological control to provide insights into how gene drive modified insects may be understood, governed, and deployed in a responsible manner. Scott et al (2017) continue the focus on gene drives in agriculture by drilling down into the realms of population biology and genetics for key pest targets for population-suppressing gene drives. They draw upon the experience of deploying the 'sterile insect technique' (SIT), which eradicated the New World screwworm fly from all of North and Central America through the mass rearing and release of irradiated flies.…”

Section: What Is Inside This Special Issue?mentioning

confidence: 99%

‘Mapping research and governance needs for gene drives’

Delborne

Kuzma

Gould

et al. 2018

Journal of Responsible Innovation

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Agricultural production: assessment of the potential use of Cas9-mediated gene drive systems for agricultural pest control

Cited by 76 publications

References 97 publications

Escalating insecticide resistance in Australian grain pests: contributing factors, industry trends and management opportunities

Escalating insecticide resistance in Australian grain pests: contributing factors, industry trends and management opportunities

Using problem formulation for fit‐for‐purpose pre‐market environmental risk assessments of regulated stressors

‘Mapping research and governance needs for gene drives’

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