Field experiments were conducted at the experimental farm Cocoa Research Institute of Nigeria (CRIN) Sub-Station, Ochaja, in the Southern Guinea Savannaagro ecological zone of Nigeria to examine uptake and use efficiencies of nutrients by Sesame and Bambara nut alley crops as influenced by manuring in a Cashew-based intercropping system. Experimental treatments were based on responses of sole and intercrop mixtures of Sesame and Bambara nut alley crops to Cocoa Pod Husk (CPH), pelletized organic fertilizer and NPK fertilizer in a cashew-based intercropping system. Data were collected on the growth and yield variables of the alley crops. Highest nitrogen harvest index (NHI) for seed and leaf of alley crops were obtained from un-manure treated plants. Cocoa pod husk (CPH) significantly enhanced P uptake compared with other fertilizers applied. CPH improved Na, Ca, Mg Zn, Cu, P, K and carbohydrate in the leaves and Ca, Mg, Zn, Fe, Cu, crude fibre and carbohydrate contents of seeds of sole crops while Sesame + Bambara had enhanced contents of N, Ca, Mg, Zn, Cu, P, N, K, moisture, protein, and crude fibre, crude protein, moisture content in leaves. The effects of NPK were significant for N, K Ca, Zn, Fe, Cu, P, moisture and crude fibre, while in the un-manure (control) plots influenced N, fat and protein and nitrogen harvest index (NHI) of leaf and seeds. CPH and NPK fertilizers enhanced nutrient uptake and nitrogen harvest index of alley crops. Nutrient uptake was similar for the varieties of Sesame and Bambara nut as affected by the application of 4.84 and 9.68 Kg pelletized organic fertilizer.