This study examines the challenges and opportunities in Nigeria’s agribusiness sector using qualitative methods, including 28 in-depth interviews, 4 focus group discussions, and 36 key informant interviews across four states. A SWOT analysis highlights strengths like abundant land, a young population, and government support, alongside weaknesses such as low technology use, poor infrastructure, and educational gaps. Opportunities include commercial farming, agrotourism, and foreign investment, while threats involve insecurity, climate change, and skill deficiencies. The study emphasizes public–private collaboration and proposes strategies like improving policy environments, enhancing food safety, boosting human capacity, and increasing financial access to drive productivity and sustainability in the sector. These strategies collectively contribute to SDG 12: Responsible Consumption and Production by promoting sustainable practices in agriculture, which are vital for long-term environmental and economic sustainability.