Background: Physalis angulata L. is a member of the Solanaceae family and is known in Indonesia as “ciplukan” which has the potential to be used as a medicinal ingredient because it acts as an immunomodulator and antioxidant. This study aims to analyse the vegetation in the ciplukan growth environment and the role of growing media in domestication efforts on the growth and yield of ciplukan. Methods: Vegetation analysis using the survey method at the survey locations was selected using a purposive random sampling method. Domestication used a completely randomized design with 1 factor, namely planting media with five levels, namely: Soil media, soil media + goat manure, soil + vermicompost media, soil + husk media, soil + charcoal husk media. Result: Based on the vegetation analysis, there are 12 grass vegetations with an important value index of 71.270% in Cynodon dactylon grass. Meanwhile, in the analysis of plant vegetation, there was 25 vegetation with the highest relative frequency in P. angulata, namely 14.286%. In the analysis of tree vegetation, there were 12 trees, with the highest density being teak, namely 42.553%. Ciplukan growing wild so far, can be domesticated as a cultivated plant. The results of domestication with the treatment of soil + vermicompost growing media can encourage the growth and yield of P. angulata plants.