AGTR2 and sprint/power performance: a case-control replication
study for rs11091046 polymorphism in two ethnicities

Yvert, Thomas; Zempo, Hirofumi; Gabdrakhmanova, Leysan J.; Kikuchi, Naoki; Miyamoto‐Mikami, Eri; Murakami, Haruka; Naito, Hisashi; Leźnicka, Katarzyna; Kostryukova, Elena S.; Alexeev, Dmitry; Egorova, Emiliya S.; Maciejewska-Skrendo, Agnieszka; Larin, Andrey K.; Generozov, Edward V.; Kulemin, Nikolay A.; Ospanova, Elena A.; Pavlenko, Alexander V.; Sawczuk, Marek; Żmijewski, Piotr; Lulińska–Kuklik, Ewelina; Govorun, Vadim M.; Miyachi, Motohiko; Ahmetov, Ildus I.; Fuku, Noriyuki

doi:10.5114/biolsport.2018.71599

Cited by 13 publications

(7 citation statements)

References 22 publications

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“…However, with regard to respective cohorts, C allele frequency was higher in Japanese male athletes than in controls, but not in Russian/Polish male athletes. In women, no significant results were obtained (Yvert et al, 2018).…”

Section: Markers Involved In Blood Pressure Controlmentioning

confidence: 99%

Genetic Markers Associated with Power Athlete Status

Maciejewska-Skrendo

Chycki

Sawczuk

et al. 2019

Journal of Human Kinetics

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Athletic performance is a multifactorial phenotype influenced by environmental factors as well as multiple genetic variants. Different genetic elements have a great influence over components of athletic performance such as endurance, strength, power, flexibility, neuromuscular coordination, psychological traits and other features important in sport. The current literature review revealed that to date more than 69 genetic markers have been associated with power athlete status. For the purpose of the present review we have assigned all genetic markers described with reference to power athletes status to seven main groups: 1) markers associated with skeletal muscle structure and function, 2) markers involved in the inflammatory and repair reactions in skeletal muscle during and after exercise, 3) markers involved in blood pressure control, 4) markers involved in modulation of oxygen uptake, 5) markers that are regulators of energy metabolism and cellular homeostasis, 6) markers encoding factors that control gene expression by rearrangement of chromatin fibers and mRNA stability, and 7) markers modulating cellular signaling pathways. All data presented in the current review provide evidence to support the notion that human physical performance may be influenced by genetic profiles, especially in power sports. The current studies still represent only the first steps towards a better understanding of the genetic factors that influence power-related traits, so further analyses are necessary before implementation of research findings into practice.

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Section: Markers Involved In Blood Pressure Controlmentioning

confidence: 99%

Genetic Markers Associated with Power Athlete Status

Maciejewska-Skrendo

Chycki

Sawczuk

et al. 2019

Journal of Human Kinetics

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“…Although these findings in West European populations support the hypothesis that the iron-increasing HFE rs1799945 G allele is favorable for endurance performance, replication studies in different ethnic groups using different designs are warranted. This approach leads to the exclusion of false-positive genetic associations (Eynon et al 2013;Zarebska et al 2017;Papadimitriou et al 2018;Yvert et al 2018;Guilherme et al 2019;Pickering et al 2019).…”

Section: Introductionmentioning

confidence: 99%

The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis

et al. 2020

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Purpose Iron is an important component of the oxygen-binding proteins and may be critical to optimal athletic performance. Previous studies have suggested that the G allele of C/G rare variant (rs1799945), which causes H63D amino acid replacement, in the HFE is associated with elevated iron indexes and may give some advantage in endurance-oriented sports. The aim of the present study was to investigate the association between the HFE H63D polymorphism and elite endurance athlete status in Japanese and Russian populations, aerobic capacity and to perform a meta-analysis using current findings and three previous studies. Methods The study involved 315 international-level endurance athletes (255 Russian and 60 Japanese) and 809 healthy controls (405 Russian and 404 Japanese). Genotyping was performed using micro-array analysis or by PCR. VO 2max in 46 male Russian endurance athletes was determined using gas analysis system. Results The frequency of the iron-increasing CG/GG genotypes was significantly higher in Russian (38.0 vs 24.9%; OR 1.85, P = 0.0003) and Japanese (13.3 vs 5.0%; OR 2.95, P = 0.011) endurance athletes compared to ethnically matched controls. The meta-analysis using five cohorts (two French, Japanese, Spanish, and Russian; 586 athletes and 1416 controls) showed significant prevalence of the CG/GG genotypes in endurance athletes compared to controls (OR 1.96, 95% CI 1.58-2.45; P = 1.7 × 10-9). Furthermore, the HFE G allele was associated with high VȮ 2max in male athletes [CC: 61.8 (6.1), CG/GG: 66.3 (7.8) ml/min/kg; P = 0.036]. Conclusions We have shown that the HFE H63D polymorphism is strongly associated with elite endurance athlete status, regardless ethnicities and aerobic capacity in Russian athletes. Keywords Gene • Genotype • Hemochromatosis • Endurance performance • Athletes Abbreviations CI Confidence intervals DNA Deoxyribonucleic acid EDTA Ethylenediaminetetraacetic acid GWAS Genome-wide association studies HFE Homeostatic iron regulator (hemochromatosis gene) HH Hereditary hemochromatosis HWE Hardy-Weinberg equilibrium PCR Polymerase chain reaction RFLP Restriction fragment length polymorphism SNP Single-nucleotide polymorphism STREGA Strengthening the reporting of genetic association TFRC Transferrin receptor VȮ 2max Maximal oxygen consumption Communicated by Michael Lindinger.

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“…BMI, body mass index. Therefore, it might increase the amount of AGTR2 production leading to increased muscle mass and type II muscle fiber type composition [11].…”

Section: Discussionmentioning

confidence: 99%

The AGTR2 (RS11091046) Gene Polymorphism is Associated with Cycling Performance in Korean Cyclists

Min¹,

Lim²,

Lee³

et al. 2022

Exerc Sci

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PURPOSE: This study aimed to investigate the association between AGTR2 (rs11091046 A>C) gene polymorphism and athletic performance.METHODS: The Korean national team cyclists enrolled in the study performed 30-second Wingate test (peak power, mean power, and power drop), one-repetition maximum (squat and bench press), and isokinetic dynamometer (60° extensor and flexor in both legs) to examine the power/sprint performance between the C and A alleles.RESULTS: The physical characteristics showed no significant difference between the C and A alleles. Comparison of physical fitness tests in cyclists revealed no significant difference between the two alleles in one-repetition maximum and isokinetic dynamometer. However, the C allele had a significantly higher peak power (10.46±0.82 vs. 9.92±0.57, p=.016) and mean power (8.30±0.48 vs. 7.95±0.47, p=.022) than A allele in the Wingate test.CONCLUSIONS: Our results demonstrate that the AGTR2 gene C allele is associated with the power/sprint performance of the Korean national team cyclists.

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AGTR2 and sprint/power performance: a case-control replication study for rs11091046 polymorphism in two ethnicities

Cited by 13 publications

References 22 publications

Genetic Markers Associated with Power Athlete Status

Genetic Markers Associated with Power Athlete Status

The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis

The AGTR2 (RS11091046) Gene Polymorphism is Associated with Cycling Performance in Korean Cyclists

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